Results 311 to 320 of about 409,825 (329)

Cleavage and inactivation of human C1 inhibitor by the human leukocyte proteinase, proteinase 3

European Journal of Immunology, 1993
AbstractIncubation of highly purified human C1 inhibitor with equally pure human leukocyte proteinase 3, resulted in a dose‐ and time‐dependent inactivation of C1 inhibitor hemolytic activity. Furthermore, this inactivation was accompanied by proteinase 3‐dependent cleavage of the C1 inhibitor into an 83 000 molecular weight fragment.
R W, Leid, B E, Ballieux, I, van der Heijden, C, Kleyburg-van der Keur, E C, Hagen, L A, van Es, F J, van der Woude, M R, Daha   +7 more
openaire   +2 more sources

Inhibition of Human Leukocyte Proteinase 3 by a Novel Recombinant Serine Proteinase Inhibitor (LEX032)

Biochemical and Biophysical Research Communications, 1997
The interaction of a bioengineered serpin (LEX032) with human leukocyte proteinase 3 (PR 3) has been investigated. LEX032 was found to be a time-dependent inhibitor of PR 3, forming a highly-stable enzyme-inhibitor complex (Ki 12 nM).
Groutas, William C., Ruan, Sumei, Kuang, Rongze, Hook, Jerry B., Sands, Howard   +4 more
openaire   +3 more sources

Proteinase 3-specific antineutrophil cytoplasmic antibody-associated vasculitis

The Lancet Rheumatology
Proteinase 3 (PR3)-specific antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is one of two major ANCA-associated vasculitis variants and is pathogenically linked to granulomatosis with polyangiitis (GPA). GPA is characterised by necrotising granulomatous inflammation that preferentially affects the respiratory tract.
Samuel D, Falde, Lynn A, Fussner, Henry D, Tazelaar, Erin K, O'Brien, Peter, Lamprecht, Maximilian F, Konig, Ulrich, Specks   +6 more
openaire   +2 more sources

ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES WITH SPECIFICITY FOR PROTEINASE 3

2007
Antineutrophil cytoplasmic antibodies (ANCA) directed against proteinase 3 (PR3) are a sensitive and specific marker for ANCA-associated systemic vasculitis and, in particular, for Wegener's granulomatosis (WG). Using indirect immunofluorescence (IIF) on ethanol-fixed neutrophils, antibodies to PR3 give a cytoplasmic staining (CANCA).
Radice, A, Sabadini, E, SINICO, RENATO ALBERTO   +2 more
openaire   +1 more source

Proteinase‐3 (PR‐3): A Polymorphonuclear Leukocyte Serine Proteinase

Annals of the New York Academy of Sciences, 1991
N V, Rao, N G, Wehner, B C, Marshall, A B, Sturrock, T P, Huecksteadt, G V, Rao, B H, Gray, J R, Hoidal   +7 more
openaire   +2 more sources

Cardiopulmonary bypass causes release of leukocyte proteinase-3

Scandinavian Journal of Clinical and Laboratory Investigation, 1996
Activation of leukocytes is an important but not fully understood event during cardiopulmonary bypass. Leukocyte proteinase-3, also known as neutrophil proteinase-4, was analysed in plasma by means of an enzyme-linked immunosorbent assay after heart surgery with extracorporeal circulation.
openaire   +2 more sources

[3] Myeloblastin: Leukocyte proteinase 3

1994
John R. Hoidal, N.V. Rao, Beulah Gray
openaire   +1 more source

Proteinase-Activated Receptor-3

2011
Anke Rattenholl, Tobias Görge, Stefan W. Schneider, Martin Steinhoff   +3 more
openaire   +1 more source

Proteinase 3

2011
openaire   +1 more source

Proteinase 3

2005
openaire   +1 more source