Results 321 to 330 of about 357,202 (334)

Inhibition of Human Leukocyte Proteinase 3 by a Novel Recombinant Serine Proteinase Inhibitor (LEX032)

Biochemical and Biophysical Research Communications, 1997
The interaction of a bioengineered serpin (LEX032) with human leukocyte proteinase 3 (PR 3) has been investigated. LEX032 was found to be a time-dependent inhibitor of PR 3, forming a highly-stable enzyme-inhibitor complex (Ki 12 nM).
Groutas, William C., Ruan, Sumei, Kuang, Rongze, Hook, Jerry B., Sands, Howard   +4 more
openaire   +4 more sources

Prophenoloxidase-activating proteinase-3 (PAP-3) from Manduca sexta hemolymph: a clip-domain serine proteinase regulated by serpin-1J and serine proteinase homologs

Insect Biochemistry and Molecular Biology, 2003
Phenoloxidase (PO) is a key enzyme implicated in several defense mechanisms in insects and crustaceans. It is converted from prophenoloxidase (proPO) through limited proteolysis by prophenoloxidase-activating proteinase (PAP). We previously isolated PAP-1 from integument and PAP-2 from hemolymph of the tobacco hornworm, Manduca sexta.
Michael R. Kanost, Haobo Jiang, Xiao-Qiang Yu, Yang Wang, Yifei Zhu   +4 more
openaire   +3 more sources

Interaction of Secretory Leukocyte Protease Inhibitor with Proteinase-3

American Journal of Respiratory Cell and Molecular Biology, 1993
Secretory leukocyte protease inhibitor (SLPI) is a 12 kD nonglycosylated serine antiproteinase secreted by cells of mucosal surfaces. In human lung, SLPI is present in the respiratory epithelium. It is the major barrier to tissue destruction mediated by the polymorphonuclear leukocyte (PMN) serine proteinases, elastase and cathepsin G, within the upper
Bruce C. Marshall, Narayanam V. Rao, John R. Hoidal, Beulah H. Gray   +3 more
openaire   +3 more sources

The Pathogenesis of Proteinase 3 ANCA-Associated Vasculitis

2023
ANCA-associated vasculitis is a rare but serious autoimmune disease, which causes inflammation and damage to blood vessels particularly in the kidneys and lungs. Treatment involves toxic medications, which can cause serious side effects and often must be continued for many years.
openaire   +1 more source

ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES WITH SPECIFICITY FOR PROTEINASE 3

2007
Antineutrophil cytoplasmic antibodies (ANCA) directed against proteinase 3 (PR3) are a sensitive and specific marker for ANCA-associated systemic vasculitis and, in particular, for Wegener's granulomatosis (WG). Using indirect immunofluorescence (IIF) on ethanol-fixed neutrophils, antibodies to PR3 give a cytoplasmic staining (CANCA).
Radice, A, Sabadini, E, SINICO, RENATO ALBERTO   +2 more
openaire   +1 more source

Autoantibodies to proteinase 3 and myeloperoxidase in systemic sclerosis.

The Journal of rheumatology, 2002
We evaluated the prevalence and clinical significance of proteinase 3 (PR3-) and myeloperoxidase (MPO-) antineutrophil cytoplasmic antibodies (ANCA) in 115 patients with systemic sclerosis (SSc, scleroderma).Sera were assayed by 2 independent centers, which used indirect immunofluorescence (IIF) and direct ELISA as screening tests. Inhibition-ELISA for
RUFFATTI, AMELIA, Sinico RA, Radice A, Ossi E, COZZI, FRANCO, Tonello M, Grypiotis P, Todesco S.   +7 more
openaire   +3 more sources

Detachment and cytolysis of human endothelial cells by proteinase 3

European Journal of Immunology, 1994
AbstractActivation and degranulation of polymorphonuclear leukocytes (PMN) with release of proteolytic enzymes, such as proteinase 3 (PR3) and elastase, in the vessels of patients with Wegener's granulomatosis (WG) is thought to play an important role in the vascular endothelial cell damage.
Fokko J. van der Woude, Mohamed R. Daha, B. E. P. B. Ballieux, Pieter S. Hiemstra, Ngaisah Klar-Mohamad, E. Christiaan Hagen, Leendert A. van Es   +6 more
openaire   +3 more sources

How does Proteinase 3 interact with lipid bilayers?

Physical Chemistry Chemical Physics, 2010
Proteinase 3 (PR3) is a serine protease of the neutrophils whose membrane expression is relevant in a number of inflammatory pathologies. It has been shown to strongly interact with reconstituted bilayers containing dimyristoylphosphatidylcholine (DMPC), dimyristoylphosphatidylglycerol (DMPG) or mixtures of both phospholipids.
Nathalie Reuter, Torben Broemstrup
openaire   +3 more sources

Proteinase 3, Wegener's autoantigen: from gene to antigen

Journal of Leukocyte Biology, 2001
AbstractProteinase 3 (PR3) is one of four serine protease homologues in the azurophilic granules of neutrophils and granules of monocytes. It is of importance that anti-neutrophil cytoplasmic antibodies (ANCA) in patients with Wegener's granulomatosis (WG) are mainly directed against PR3 only. Furthermore, PR3 is overexpressed in a variety of acute and
Pieter Limburg, YM Van der Geld, Cornelis Kallenberg   +2 more
openaire   +3 more sources

Proteinase‐3 (PR‐3): A Polymorphonuclear Leukocyte Serine Proteinase

Annals of the New York Academy of Sciences, 1991
Thomas P. Huecksteadt, Narayanam V. Rao, Nancy G. Wehner, Anne Sturrock, Gopna V. Rao, Bruce C. Marshall, Beulah H. Gray, John R. Hoidal   +7 more
openaire   +3 more sources