Results 131 to 140 of about 37,765 (303)

The spectrum and activity of urinary Ig-proteinases as a marker of chronic pyelonephritis

Терапевтический архив, 2004
Aim. To study the activity of Ig-splitting proteinases of various classes in the urine in patients with chronic pyelonephritis. Material and methods. Clinical, device and laboratory examinations were made in 50 patients (age 20-60 years).
О D Zinkevich, Yu A Glushko, N A Safina, Yu A Tyurin   +3 more
doaj  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The role of lysosomal cysteine proteinases as markers of macrophage activation and as non-specific mediators of inflammation [PDF]

, 1993
Assfalg-Machleidt, Irmgard, D. Nast-Kolb, Joka, T., M. Jochum, Faist, E., Billing, A., Fröhlich, D., A. Billing, Machleidt, W., Schildberg, F. W., W. Machleidt, T. Joka, I. Assfalg-Machleidt, Nast-Kolb, Dieter, Jochum, Marianne, D. Fröhlich, Meakins, J.   +16 more
core   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Activity trypsin-like proteinases and intestinal mucosa collagen degradation at gastro-intestinal diseases

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2010
Aim of investigation. To determine activity of trypsin-, collagenase- and elastase-like proteinases, a1- proteinase inhibitor, a2-macroglobulin and contents of hydroxyproline in intestinal mucosa and blood plasma of patients with bowel diseases.Material ...
О. E. Akbasheva, V. A. Burkovskaya, A. E. Dehand, E. I. Beloborodova, L. A. Akimova, E. L. Naumova, E. A. Kvach   +6 more
doaj  

Fusarium species synthesize alkaline proteinases in infested barley

, 2003
Barley (Hordeum vulgare L.) that is infested with Fusarium head blight (FHB, ‘scab’) is unsuitable for malting and brewing because it may contain mycotoxins and has unacceptable malting quality.
Laitila, Arja, Sarlin, Tuija, Pekkarinen, Anja, Haikara, Auli, Jones, Berne L.   +4 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source