Results 111 to 120 of about 10,267 (203)
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Regulation of C1-inhibitor and its target proteinases by endothelial cells.
, 2005 Regulation of C1-inhibitor and its target proteinases by endothelial ...
Sriram. Ravindran (7956092)
core +3 more sources
Bacillus pumilus strains with inactivated genes of extracellular serine proteinases
, 2020 Two Bacillus pumilus strains with inactivated genes of extracellular serine proteinases (subtilisin-like proteinase and glutamyl endopeptidase) were obtained.
Shagimardanova E. +7 more
core
Synthesis and secretion of proteinases by Bacillus intermedius in the late stages of sporulation [PDF]
, 2003 In the late stages of sporulation, cells of Bacillus intermedius 3-19 secreted into the medium two proteinases, glutamyl endopeptidase and subtilisin, whose maximum activities were recorded in the 40th and 44th hours of growth, respectively.
Leshchinskaya I. +7 more
core
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
The spectrum and activity of urinary Ig-proteinases as a marker of chronic pyelonephritis
Терапевтический архив, 2004 Aim. To study the activity of Ig-splitting proteinases of various classes in the urine in patients with chronic pyelonephritis. Material and methods. Clinical, device and laboratory examinations were made in 50 patients (age 20-60 years).
О D Zinkevich +3 more
doaj
Synthesis and secretion of proteinases by Bacillus intermedius in the late stages of sporulation
, 2020 In the late stages of sporulation, cells of Bacillus intermedius 3-19 secreted into the medium two proteinases, glutamyl endopeptidase and subtilisin, whose maximum activities were recorded in the 40th and 44th hours of growth, respectively.
Leshchinskaya I. +7 more
core