Results 111 to 120 of about 40,422 (295)
Bacillus pumilus strains with inactivated genes of extracellular serine proteinases [PDF]
, 2013 Two Bacillus pumilus strains with inactivated genes of extracellular serine proteinases (subtilisin-like proteinase and glutamyl endopeptidase) were obtained.
Shagimardanova E. +7 more
core
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Activation of macrophage promatrix metalloproteinase-9 by lipopolysaccharide-associated proteinases.
, 2002 LPS induces an up-regulation of promatrix metalloproteinase-9 (proMMP9) gene expression in cells of the monocyte/macrophage lineage. We demonstrate here that LPS preparations are also able to activate proMMP9 made by human macrophages or THP-1 cells via ...
Bain, Michael A +4 more
core +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
PROTEINASES AND PROTEINASE INHIBITORS IN FERTILIZATION [PDF]
, 1976 Schleuning, W. D. +4 more
openaire +2 more sources
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Cancer biology: Extracellular proteinases in malignancy
, 1999 Secreted, matrix-degrading proteinases have been viewed as contributing to tumor metastasis. A recent study indicates that the gene for one of these enzymes, the matrix metalloproteinase stromelysin-1, can actually cause cancer when expressed in ...
Matrisian, Lynn M
core +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Bacillus pumilus strains with inactivated genes of extracellular serine proteinases
, 2020 Two Bacillus pumilus strains with inactivated genes of extracellular serine proteinases (subtilisin-like proteinase and glutamyl endopeptidase) were obtained.
Shagimardanova E. +7 more
core
Synthesis and secretion of proteinases by Bacillus intermedius in the late stages of sporulation [PDF]
, 2003 In the late stages of sporulation, cells of Bacillus intermedius 3-19 secreted into the medium two proteinases, glutamyl endopeptidase and subtilisin, whose maximum activities were recorded in the 40th and 44th hours of growth, respectively.
Leshchinskaya I. +7 more
core