Results 231 to 240 of about 35,571 (308)

Infection by Different Clades of Candidozyma auris in a Galleria mellonella Model: Determining Virulence Levels. [PDF]

Mycopathologia
Marena GD, Lopez A, Carvalho GC, Pemán J, Perez-Royo JM, Garcia-Bustos V, González Á, Brell PM, Ruiz MDP, Macian LZ, Saez CV, Mansilla AA, Bauab TM, Chorilli M, Ruiz-Gaitán A.   +14 more
europepmc   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

A Urease-Based pH Photoswitch: A General Route to Light-to-pH Transduction. [PDF]

Angew Chem Int Ed Engl
Ivanov NM, Slivkov AI, Huck WTS.
europepmc   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

The Versatility of Serine Proteases from Brazilian <i>Bothrops</i> Venom: Their Roles in Snakebites and Drug Discovery. [PDF]

Biomolecules
Romanazzi M, Filardi ETM, Pires GMM, Cerveja MF, Melo-Dos-Santos G, Oliveira IS, Ferreira IG, Cerni FA, Santos-Filho NA, Monteiro WM, Almeida JR, Vaiyapuri S, Pucca MB.   +12 more
europepmc   +1 more source

Climate Change Threatens Micronutrient Density of European Winter Wheat

Advanced Science, EarlyView.
Micronutrients are vital for human health. Wheat is a major staple crop and a significant source of minerals and B‐vitamins. The impact of climate change on their content remains largely unknown. We evaluated micronutrient levels in European winter wheat grown under historical and projected climate conditions. Our findings indicate that future climates
Da Cao, Jennifer Michel, Eline Lorer, Markus Weinmann, Jacques Le Gouis, Claire Léon, Sibille Perrochon, David Alvarez, Vincent Leemans, Iñaki Balanzategui Guijarro, Jordi Moya Laraño, Sara Sánchez Moreno, Symanczik Sarah, Waibel Matthias, Hervé Vanderschuren, Cécile Thonar, Pierre Delaplace, Dominique Van Der Straeten   +17 more
wiley   +1 more source

<i>Coffea arabica</i> Extracts and Metabolites with Potential Inhibitory Activity of the Major Enzymes in <i>Bothrops asper</i> Venom. [PDF]

Pharmaceuticals (Basel)
Páez E, Galvis-Pérez Y, Pereañez JA, Preciado LM, Henao-Castañeda IC.   +4 more
europepmc   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

The ADAMTS family: from extracellular matrix proteases to orchestrators of fibrosis. [PDF]

Cell Commun Signal
Yuan Y, Guo P, Song Y, Yu Z, Song B.
europepmc   +1 more source

Secreted Aspartic Proteinases: Key Factors in <i>Candida</i> Infections and Host-Pathogen Interactions. [PDF]

Int J Mol Sci
Bras G, Satala D, Juszczak M, Kulig K, Wronowska E, Bednarek A, Zawrotniak M, Rapala-Kozik M, Karkowska-Kuleta J.   +8 more
europepmc   +1 more source