Results 211 to 220 of about 10,718,710 (345)

RNA-Binding Proteins in Dinoflagellates. [PDF]

Int J Mol Sci
Berdieva M, Safonov P, Skarlato S.
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

MALDI spatial proteomics: a mini review of approaches and techniques.

Anal Methods
Lopez A, Hummon AB.
europepmc   +1 more source

Exploring the impact of age, sex and life experiences on plasma inflammatory profiles through comparative proteomics. [PDF]

Front Immunol
Bartolucci M, Utyro O, Muraglia A, Repetto A, Agostini V, Pizzonia M, Ottaviani S, Tripodi G, Filaci G, Cancedda R, Petretto A, Mastrogiacomo M.   +11 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Exploring molecular signatures in PURA syndrome using muscle proteomics and serum biomarkers. [PDF]

J Neurol
Mroczek M, Preusse C, Hentschel A, Chrościńska-Krawczyk M, Bielak M, Sobolewska A, Della Marina A, Hila A, Iyadurai S, Kraft F, Chetty VK, Muhmann D, Ruck T, Goebel HH, Schara-Schmidt U, Dobelmann V, Thakur BK, Stenzel W, Roos A.   +18 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

CSF proteomic profiling with amyloid and tau pathology identifies distinctive sex-specific alteration of multiple proteins involved in Alzheimer's disease. [PDF]

Alzheimers Dement
Do AN, Song S, Ali M, Timsina J, Wang L, Western D, Liu M, Sanford J, Rosende-Roca M, Boada M, Puerta R, Wilson EN, Ruiz A, Pastor P, Alzheimer's Disease Neuroimaging Initiative (ADNI), Wyss-Coray T, Cruchaga C, Sung YJ.   +17 more
europepmc   +1 more source

The RNA-binding protein RRP1 brakes macrophage one-carbon metabolism to suppress autoinflammation [PDF]

Yu-Mei Zhou, Mengxuan Li, Ke Jin, Mingyue Wen, Hua Qin, Yue Xu, Chunmei Wang, Xuan Zhang, Xuetao Cao   +8 more
openalex   +1 more source

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

Science, 2011
Shinsuke Ito, Li Shen, Qing Dai, Susan C. Wu, L. Collins, J. Swenberg, Chuan He, Yi Zhang   +7 more
semanticscholar   +1 more source