Results 241 to 250 of about 13,339,631 (403)

An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals [PDF]

, 1959
Oliver Smithies
openalex   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

The Rab3 family proteins in age-related neurodegeneration: unraveling molecular pathways and potential therapeutic targets. [PDF]

NPJ Aging
He H, Ai R, Fang EF, Palikaras K.
europepmc   +1 more source

The chemistry of connective tissues. 2. Soluble proteins derived from partial hydrolysis of elastin [PDF]

, 1955
S. M. Partridge, H. F. Davis, G. S. Adair   +2 more
openalex   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Enrichable cross-linkers for mapping direct protein interactions. [PDF]

Genome Biol
Wu T, Zhou HX, Tian J, Zhou R, Huangfu S, Jin BK, Sablina A, Zhou F, Chen H, Tang S, Zhang L, Yang B.   +11 more
europepmc   +1 more source

Active Site of Papain and Covalent “High Energy” Bonds of Proteins

, 1958
Emil L. Smith
openalex   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Proteins with cognition-associated structural changes in a rat model of aging exhibit reduced refolding capacity. [PDF]

Sci Adv
Tarbox HE, Branch A, Fried SD.
europepmc   +1 more source

THE ISOTOPE DERIVATIVE METHOD OF PROTEIN AMINO END-GROUP ANALYSIS

, 1951
Sidney Udenfriend, Sidney F. Velick
openalex   +1 more source