Clinical Pharmacology &Therapeutics, EarlyView.Iptacopan, a first‐in‐class complement factor B inhibitor acting proximally in the alternative complement pathway, has been shown to be safe and effective for patients with complement‐mediated diseases. Iptacopan selectively binds with high affinity to factor B, a soluble, plasma‐based, hepatically produced protein.
Elise Burmeister Getz +8 more
wiley +1 more source
Massive Urinary Protein Excretion Associated with Greater Neonatal Risk in Preeclampsia
American Journal of Perinatology Reports, 2017 Objective The objective of this study was to compare clinical outcomes of preeclamptic pregnancies according to the proteinuria level. Study Design Secondary analysis of a multicenter prospective cohort study of women with preeclampsia (PE ...
Julio Mateus +10 more
doaj +1 more source
Journal of International Medical Research, 2020 Objectives To evaluate the association between proteinuria and maternal and neonatal outcomes in pregnant women with pre-eclampsia. Methods This retrospective study included patients beyond 20 weeks of gestation diagnosed with pre-eclampsia, who were ...
Xiangxiang Xu +4 more
doaj +1 more source
Progress in Pathogenesis of Proteinuria
International Journal of Nephrology, 2012 Aims. Proteinuria not only is a sign of kidney damage, but also is involved in the progression of renal diseases as an independent pathologic factor. Clinically, glomerular proteinuria is most commonly observed, which relates to structural and functional
Aihua Zhang, Songming Huang
doaj +1 more source
Relationship Between Alcohol Drinking Pattern and Risk of Proteinuria: The Kansai Healthcare Study
Journal of Epidemiology, 2016 Background: Moderate alcohol consumption has been reported to be associated with a decreased risk of cardiometabolic diseases. Whether drinking pattern is associated with the risk of proteinuria is unknown.
Shinichiro Uehara
doaj +1 more source
Prevalence of and Risk Factors for Paroxysmal Atrial Fibrillation in Patients with Cardiovascular Disease but without diagnosed Atrial Fibrillation [PDF]
, 2019 学位記番号 ...
Niijima, Katsura +2 more
core
Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. [PDF]
, 2000 Protease-activated receptor (PAR)-1 is a cellular receptor for thrombin that is activated after proteolytic cleavage. The contribution of PAR-1 to inflammatory cell-mediated renal injury was assessed in murine crescentic glomerulonephritis (GN).
Bernatowicz +33 more
core +3 more sources
Targeting tubulointerstitial remodeling in proteinuric nephropathy in rats
Disease Models & Mechanisms, 2015 Proteinuria is an important cause of tubulointerstitial damage. Anti-proteinuric interventions are not always successful, and residual proteinuria often leads to renal failure.
Saleh Yazdani +6 more
doaj +1 more source
Regulation of autoimmunity and donor cell engraftment by recipient Lyt-2+ cells during the graft-versus-host reaction. [PDF]
, 1987 When lymphocytes from DBA/2 mice are transferred to (C57BL X DBA/2)F1 (BDF1) mice, the ensuing graft-vs.-host reaction (GVHR) causes an autoimmune illness resembling human SLE.
Harper, SE, Roubinian, JR, Seaman, WE
core +1 more source
Case of severe hypertension and nephrotic range proteinuria [PDF]
, 2018 No abstract ...
Bursztyn, Michael +4 more
core +1 more source