Results 61 to 70 of about 187,783 (355)

Deletion of Pyruvate Carboxylase in Tubular Epithelial Cell Promotes Renal Fibrosis by Regulating SQOR/cGAS/STING‐Mediated Glycolysis

Advanced Science, EarlyView.
Pyruvate carboxylase (PC), as a catalytic enzyme located within the mitochondria, plays an important role in kidney fibrosis. PC deficiency reduces its interaction with sulfide:quinone oxidoreductase (SQOR), increasing the ubiquitination and degradation of SQOR.
Hao Huang, Yuanyuan Han, Yan Zhang, Jianhua Zeng, Xin He, Jiawei Cheng, Songkai Wang, Yiwei Xiong, Hongling Yin, Qiongjing Yuan, Ling Huang, Yanyun Xie, Jie Meng, Lijian Tao, Zhangzhe Peng   +14 more
wiley   +1 more source

A PROSPECTIVE COHORT STUDY OF PROTEINURIA CHANGES AND MYOCARDIAL INFARCTION RISKS IN DIABETIC OR PRE-DIABETIC PATIENTS.

Student's Journal of Health Research Africa, 2023
Objective:  This prospective cohort study aimed to investigate the relationship between changes in proteinuria and the risk of myocardial infarction (MI) in individuals with diabetes or pre-diabetes.
Sanjay Kumar, Rashmi Rani Bharti, Mamta Kumari, Guddi Rani Singh   +3 more
doaj  

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Acute kidney injury: an acceptable risk of treatment with renin-angiotensin system blockade in primary care? [PDF]

, 2015
Background: Use of renin-angiotensin system (RAS) blockade has become increasingly widespread driven by evidence-based guidance. There is concern about the role of these agents in the genesis of avoidable acute kidney injury (AKI).
Bellomo R, Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group Members, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence   +7 more
core   +2 more sources

Acción antiproteinúrica del amiloride en el paciente pediátrico con síndrome nefrótico corticorresistente

Nefrología, 2021
Resumen: Introducción: En el síndrome nefrótico, la podocituria aumentada acompaña a la proteinuria patológica. El tratamiento con enalapril, losartán y amiloride podría reducir ambas variables.
Miguel Liern, Anabella Colazo, Graciela Vallejo, Elsa Zotta   +3 more
doaj  

Effect of Blood Pressure Control on Long-Term Risk of End-Stage Renal Disease and Death Among Subgroups of Patients With Chronic Kidney Disease. [PDF]

, 2019
Background Our objective was to explore the effect of intensive blood pressure (BP) control on kidney and death outcomes among subgroups of patients with chronic kidney disease divided by baseline proteinuria, glomerular filtration rate, age, and body ...
Hsu, Chi-Yuan, Ku, Elaine, Lin, Feng, McCulloch, Charles E, Sarnak, Mark J, Smogorzewski, Miroslaw, Toto, Robert   +6 more
core  

Effect of mineralocorticoid receptor antagonists on proteinuria and progression of chronic kidney disease: a systematic review and meta-analysis [PDF]

, 2016
Background: Hypertension and proteinuria are critically involved in the progression of chronic kidney disease. Despite treatment with renin angiotensin system inhibition, kidney function declines in many patients.
Boesby, Lene, Currie, Gemma, Delles, Christian, Edwards, Nicola C., Ferro, Charles J., Fujita, Toshiro, Jardine, Alan G., Lindhart, Morten, Mark, Patrick B., Ohtsu, Hiroshi, Oveisi, Sonia, Preiss, David J., Rossing, Peter, Saklayen, Mohammad G., Taylor, Alison H.M., Townend, Jonathan N., van den Meiracker, Anton H.   +16 more
core   +2 more sources

The compound heterozygous mutations of c.607G>a and c.657delC in the FAH gene are associated with renal damage with hereditary tyrosinemia type 1 (HT1)

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
This study demonstrated the novel compound heterozygous mutations (NM_000137: c.657delC (p.K220Rfs*12) and NM_000137: c.607G>A(p.A203T)) in FAH gene in a patient were responsible for HT1. We showed these FAH mutations were inherited in an autosomal recessive manner and resulted in abnormal FAH protein expression and dysfunction, leading to ...
Huan Chi, Chun Gan, Yaru Jiang, Dan Chen, Jiawen Qiu, Qing Yang, Yaxi Chen, Mo Wang, Haiping Yang, Wei Jiang, Qiu Li   +10 more
wiley   +1 more source

Association between proteinuria and placental pathology in preeclampsia: A retrospective study

SAGE Open Medicine, 2021
Introduction: Preeclampsia develops due to placental insufficiency and systemic proinflammatory and antiangiogenic mediator release, with ensuing systemic endothelial dysfunction.
Dominique Suzanne Genest, Dorothée Dal Soglio, Sylvie Girard, Evelyne Rey   +3 more
doaj   +1 more source

Risk factors for Early onset of Proteinuria in Patients Receiving Atezolizumab Plus Bevacizumab for Unresectable Hepatocellular Carcinoma.

Liver Cancer, 2022
Introduction Proteinuria is one of the adverse events of atezolizumab plus bevacizumab combination therapy (Atezo+Bev) and can cause interruption in the use of Bev. However, the risk factors for proteinuria in patients with hepatocellular carcinoma (HCC)
Yuwa Ando, Tomokazu Kawaoka, Masanari Kosaka, Yuki Shirane, Yusuke Johira, Ryoichi Miura, Serami Murakami, Shigeki Yano, Kei Amioka, Kensuke Naruto, Yumi Kosaka, Shinsuke Uchikawa, Kenichiro Kodama, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Masami Yamauchi, Wataru Okamoto, Shoichi Takahashi, Michio Imamura, Hiroshi Aikata   +21 more
doaj   +1 more source