Results 221 to 230 of about 183,121 (297)

Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities

Advanced Science, EarlyView.
The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley   +1 more source

DICED (Database of Identified Cleavage Sites Endemic to Diseases States): A Searchable Web Interface for Terminomics/Degradomics. [PDF]

Proteomics
Joshi J, Bhutada S, Martin DR, Guzowski J, Blankenberg D, Apte SS.   +5 more
europepmc   +1 more source

Energy Deficiency‐Induced ATG4B Nuclear Translocation Inhibits PRMT1‐Mediated DNA Repair and Promotes Leukemia Progression

Advanced Science, EarlyView.
This study demonstrated that ATG4B translocates from the cytoplasm to the nucleus during energy deficiency. Nuclear ATG4B inhibits DNA repair by interacting with PRMT1. The nuclear ATG4B‐mediated DNA repair defect is significantly exacerbated within acute myeloid leukemia (AML) cells, promoting leukemia progression in an AML mouse model.
Zhenkun Wang, Xianli Zhang, Yuanyuan Zhou, Shuyi Lin, Yuting Fu, Haiping Liu, Qiongdan Gao, YanHong Xiao, Zhao Yin, Shuang Liu, Kexiu Huang, Suqi Deng, Juan Du, Hui Zeng, Jia Wang, Jinping Zheng, Qinghua Zhou, Tianfeng Chen, Xiaoling Gao, Zhenyu Ju, Bo Liu   +20 more
wiley   +1 more source

Angiotensin II Type 1 Receptor Blocker Usage Prevents Oxidative Stress and Muscle Dysfunction in HIV. [PDF]

Fundam Clin Pharmacol
Deminice R, Cella PS, Borsari AL, Padilha CS, de Oliveira VHF.   +4 more
europepmc   +1 more source

Polycystin‐1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1‐Dependent Microfilament Remodeling

Advanced Science, EarlyView.
Polycystin‐1 (PC1) senses collagen and ECM stiffness to promote tumor migration via Daam1‐mediated actin remodeling. A cleavage‐resistant PC1 mutant enhances YAP nuclear translocation and CTGF expression, which activates CAFs and further stiffens the ECM, forming a feed‐forward loop that drives tumor progression and metastasis.
Jiaofeng Zhou, Yibing Deng, Jie Mei, Mengyun Wan, Ningyi Xue, Xinyu Zong, Ji Zhou, Junli Ding, Ting Yan, Yu Jiang, Tiansong Xia, Peng Zheng, Yichao Zhu   +12 more
wiley   +1 more source

Effects of a methionine deficiency on chicken tissue protein turnover: comparative analysis of methionine source. [PDF]

Poult Sci
Conde-Aguilera JA, Métayer-Coustard S, Mercier Y, van Milgen J, Tesseraud S.   +4 more
europepmc   +1 more source

Separation of the hormone- and DNA-binding sites of the hepatic glucocorticoid receptor by means of proteolysis.

, 1978
Örjan Wränge, Jan-Ακε Gustafsson
openalex   +1 more source

Artificial Intelligence‐Driven Proteomics Identifies Plasma Protein Signatures for Diagnosis and Stratification of Behçet's Disease

Advanced Science, EarlyView.
Molecular and functional landscape of BD progression and severity based on in‐depth proteomics. Tree boosting machine learning models with favorable performance in BD diagnosis and stratification. Efficient biomarker panels for BD diagnosis and stratification. .
Linlin Cheng, Mansheng Li, Zhou Bai, Xiaobo Yu, Wenjie Zheng, Yongzhe Li, Yudong Liu   +6 more
wiley   +1 more source

Corrigendum: Transient proteolysis reduction of <i>Nicotiana benthamiana</i>-produced CAP256 broadly neutralizing antibodies using CRISPR/Cas9. [PDF]

Front Plant Sci
Singh AA, Pillay P, Naicker P, Alexandre K, Malatji K, Mach L, Steinkellner H, Vorster J, Chikwamba R, Tsekoa TL.   +9 more
europepmc   +1 more source

Plasmin-mediated proteolysis of casein in bovine milk.

, 1979
W.N. Eigel, Christina Hofmann, B A Chibber, John M. Tomich, T. W. Keenan, E. T. Mertz   +5 more
openalex   +1 more source