Results 91 to 100 of about 264,068 (308)
Advanced Functional Materials, EarlyView.We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins +9 more
wiley +1 more source
, 2013 This PhD thesis is aimed at studying the suitability of proteases realised by Yarrowia lipolytica to hydrolyse proteins of different origins available as industrial food by-products. Several strains of Y.
Gottardi, Davide <1983>
core +1 more source
ssRNA inhibits the proteolytic activity of NS2B-NS3pro.
, 2023 Inhibition of ZIKV NS2B-NS3pro proteolytic activity by ssRNA (20-rA, left) and ssDNA (20-dA, right).
Robert C. Liddington (35197) +4 more
core +1 more source
Regulation of Proteolytic Activity by Engineered Tridentate Metal Binding Loops
, 2016 Regulation of Proteolytic Activity by Engineered Tridentate Metal Binding ...
Sherin Halfon (2995359) +1 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
Proteolytic Activity in Developing Bovine Enamel
, 1979 Partially mineralized enamel matrix removed from bovine incisor tooth germs contains proteolytic activity capable of completely degrading enamel matrix proteins at neutral and slightly alkaline pH.
H. Birkedal-Hansen, D. Moe
core +1 more source
Acta Societatis Botanicorum Poloniae, 2014 The autolytic protease system in maturing tracheids of the main stem of Pinus silvestris was investigated after separation (using surgical methods) of the cambial zone from the layer of differentiating xylem, in combination with decapitation and IAA ...
Jacek Zakrzewski, Krzysztof Rakowski
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Our coaxial electrospinning system is capable of incorporating decellularized myocardial extracellular matrix in a core‐sheath configuration, creating nanofibrous scaffolds. These scaffolds, in turn, support the maintenance of functional cardiomyocytes adhered to the surface of these bioactive scaffolds.
Dhanusha N. Rajapakse +9 more
wiley +1 more source
Monitoring of proteolytic activity in neutrophil extracellular traps.
, 2013 A. Identification of an internally quenched fluorescent substrate that is hydrolyzed by NE, CG and PR3. B. Extracellular proteolytic activity was analyzed from 3 donor neutrophils (Donor 1, dark grey; Donor 2, black; Donor 3, light grey) following ...
Ye Jin (286793) +7 more
core +1 more source
Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation
Advanced Healthcare Materials, EarlyView.This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad +7 more
wiley +1 more source