Results 81 to 90 of about 264,068 (308)
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Determination of proteolytic enzyme activity during malting
Kvasný průmysl, 2018 Proteolytic enzymes (proteases) are widely represented in living organisms where they catalyze the hydrolysis of peptide bonds in proteins and peptides.
Karolína Benešová +3 more
doaj +1 more source
The effect of melanin on the proteolytic potential of blood under alkali esophageal burn
Journal of Biological Research, 2020 Caustic esophageal burns are among serious medical problems of global significance. Due to a key role in biological processes proteolytic enzymes actively involved in the pathological mechanisms underpinning the development and progression of burn ...
Nataliia Chornenka +9 more
doaj +1 more source
The proteolytic activity of Listeria monocytogenes HtrA
BMC Microbiology, 2019 Background High temperature requirement A (HtrA) is a widely expressed chaperone and serine protease in bacteria. HtrA proteases assemble and hydrolyze misfolded proteins to enhance bacterial survival under stress conditions.
Carmen M. Abfalter +5 more
doaj +1 more source
Advanced Functional Materials, EarlyView.A biomimetic hydrogel derived from neonatal spinal cord ECM (DNSCM) delivers LAMB2 protein and ISP peptide to remodel the inhibitory injury microenvironment. The system sustains drug release, upregulates pro‐regenerative LAMB2, downregulates inhibitory CSPG, and promotes axonal regeneration.
Shiyu Fu +8 more
wiley +1 more source
, 2007 Chronic ulcers are an important and costly medical issue, causing their sufferers a large amount of pain, immobility and decreased quality of life. The common pathology in these chronic wounds is often characterised by excessive proteolytic activity ...
Rayment, Erin Alexis
core
Interferon y Stimulation Modulates the Proteolytic Activity and Cleavage Site Preference of 20S Mouse Proteasomes [PDF]
, 1994 The proteasome is a 700-kD multisubunit enzyme complex with several proteolytically active sites. The enzyme complex is involved in both ubiquitin-dependent and -independent protein degradation and may contribute to the processing of antigens presented ...
Multhaupt, Gerd +5 more
core
Microfabricated Anisotropic Myobundles for the Scalable Production of Cardiac Tissue Grafts
Advanced Functional Materials, EarlyView.Controlling the anisotropy of cardiac tissue remains an outstanding challenge in the field of cardiac tissue engineering. Here, we introduce an approach to generate anisotropic cardiac myobundles using cell‐adhesive, synthetic, electrospun fibers and stem cell‐derived cardiac fibroblasts.
Maggie E. Jewett +15 more
wiley +1 more source
Proteolytic Activity of Hemophilic Plasma.
Experimental Biology and Medicine, 1949 Summary1. A method is described by which the proteolytic activity of human normal and hemophilic plasmas may be compared.2. The proteolytic activity of 3 hemophilic plasmas was found to be comparable to that of normal plasmas.
openaire +2 more sources