Results 81 to 90 of about 6,061,554 (251)
Modeling the development of proteolytic phenotypes in multi-species oral biofilms
Journal of Oral Microbiology, 2017 In chronic periodontitis, subgingival biofilms induce an inflammatory response leading to periodontal tissue destruction which may cause tooth loss. The response includes exudation of fluid (GCF) from the gingival pocket, giving rise to a protein-rich ...
Julia R. Davies +2 more
doaj +1 more source
Advanced Functional Materials, EarlyView.A multicomponent supramolecular hydrogel integrating cell‐adhesive and antibacterial peptides within an alginate‐cellulose nanofibril matrix is developed. Peptide co‐assembly simultaneously strengthens the hydrogel network, improves extrusion printability, and imparts cell‐adhesive and antibacterial functions, offering a versatile platform for ...
Mor Tsuriano‐Zernichov +4 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira +8 more
wiley +1 more source
Determination of proteolytic enzyme activity during malting
Kvasný průmysl, 2018 Proteolytic enzymes (proteases) are widely represented in living organisms where they catalyze the hydrolysis of peptide bonds in proteins and peptides.
Karolína Benešová +3 more
doaj +1 more source
The proteolytic activity of Listeria monocytogenes HtrA
BMC Microbiology, 2019 Background High temperature requirement A (HtrA) is a widely expressed chaperone and serine protease in bacteria. HtrA proteases assemble and hydrolyze misfolded proteins to enhance bacterial survival under stress conditions.
Carmen M. Abfalter +5 more
doaj +1 more source
Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development
Advanced Healthcare Materials, EarlyView.LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans +7 more
wiley +1 more source
3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress
Advanced Materials Technologies, EarlyView.Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi +4 more
wiley +1 more source
Acta Societatis Botanicorum Poloniae, 2014 The autolytic protease system in maturing tracheids of the main stem of Pinus silvestris was investigated after separation (using surgical methods) of the cambial zone from the layer of differentiating xylem, in combination with decapitation and IAA ...
Jacek Zakrzewski, Krzysztof Rakowski
doaj +1 more source
Advanced Science, EarlyView.IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu +8 more
wiley +1 more source
Charting Endocrine Progenitors Across Species and Organs
Advanced Science, EarlyView.Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing +21 more
wiley +1 more source