Results 141 to 150 of about 6,061,554 (251)

The Effect of Cannabidiol (CBD) on the Modulation of Proteolytic Activity on the Honey Bee Workers' Cuticle. [PDF]

Molecules
Staniszewska P, Staniszewski A, Gryboś A, Bryś MS, Strachecka A.   +4 more
europepmc   +1 more source

DQ-BSA proteolytic activity assay v1

This protocol measures lysosomal proteolytic activity in human iPSC-derived astrocytes using DQ Red BSA (Thermo D12051). Upon lysosomal proteolysis, DQ-BSA becomes fluorescent, allowing quantification by live-cell imaging or flow cytometry.
Camille Goldman
core   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Degradation graphs reveal hidden proteolytic activity in peptidomes. [PDF]

PLoS Comput Biol
Hartman E, Malmström J, Wallin J.
europepmc   +1 more source

Extracellular Vesicles Secreted by Acanthamoeba culbertsoni Have COX and Proteolytic Activity and Induce Hemolysis. [PDF]

Microorganisms, 2023
Sierra-López F, Castelan-Ramírez I, Hernández-Martínez D, Salazar-Villatoro L, Segura-Cobos D, Flores-Maldonado C, Hernández-Ramírez VI, Villamar-Duque TE, Méndez-Cruz AR, Talamás-Rohana P, Omaña-Molina M.   +10 more
europepmc   +1 more source

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Advanced Science, EarlyView.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang   +20 more
wiley   +1 more source

Single-Particle Plasmon Sensor to Monitor Proteolytic Activity in Real Time. [PDF]

ACS Appl Opt Mater, 2023
Oliveira-Silva R, Wang Y, Nooteboom SW, Prazeres DMF, Paulo PMR, Zijlstra P.   +5 more
europepmc   +1 more source

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Bacterial and fungal co-colonization alters <i>Malassezia restricta</i> metabolism and host proteolytic activity in reconstructed human epidermis. [PDF]

Front Microbiol
Lyou ES, Yoo SH, Rhee KJ, Johnson DR, Lee TK.   +4 more
europepmc   +1 more source

Express Diagnostics of Proteolytic Activity of Periodontopathogens-Methodological Approach. [PDF]

Dent J (Basel), 2022
Aronova E, Dmitrienko M, Ivanova A, Gaykova Y, Kurochkina A, Blinova A, Bazarnova J, Paponova E.   +7 more
europepmc   +1 more source