Results 121 to 130 of about 6,061,554 (251)

Proteolytic activity in Nepenthes.

, 2015
A Samples of the pitcher fluid of ten different Nepenthes species were investigated for their PFU-093 cleaving activity. B Kinetics of proteolytic PFU-093 cleaving activity in pitcher fluid from open (grey line) and closed (black line) pitchers of ...
Franziska Buch (699483), Wendy E. Kaman (490090), Ayufu Yilamujiang (699484), Axel Mithöfer (699485), Floris J. Bikker (490093)   +4 more
core   +1 more source

SIZ1‐Mediated SUMOylation of LBD29 Recruits ARF7 to Fine‐Tune Auxin Signaling in Lateral Root Development

Advanced Science, EarlyView.
Our findings establish SUMOylation as a key post‐translational control layer in auxin signaling. We show that SIZ1‐mediated SUMOylation of LBD29 promotes its association with ARF7, stabilizing a transcriptional hub that governs lateral root development.
Jiaxuan Sui, Qianlan Yin, Yiying Chen, Liping Zhang, Xiuyuan Yu, Qianqian Yu, Zhaojun Ding, Xiangpei Kong   +7 more
wiley   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

INFLAMMATION AND PROTEOLYTIC ACTIVITY IN CROHN’S DISEASE

Background: The pathogenesis of inflammatory bowel disease, comprising of Crohn’s disease (CD) and ulcerative colitis (UC) involves host, genetic and environmental interactions, that include microbial factors.
Szeto, Janet
core   +1 more source

Regulation of Proteolytic Activity by Engineered Tridentate Metal Binding Loops

, 2016
Regulation of Proteolytic Activity by Engineered Tridentate Metal Binding ...
Sherin Halfon (2995359), Charles S. Craik (174573)   +1 more
core   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Proteolytic activity of selected functional starter cultures

, 2013
Cilj ovog rada bio je ispitati proteolitičku aktivnost autohtonih sojeva bakterija mliječne kiseline izoliranih iz hrvatskog tradicionalnog svježeg sira.
Rodin, Anja
core   +2 more sources

AEBSF reduces proteolytic activity in BALF.

, 2013
Proteolytic activity in term of OD/(mg.h) in ovalbumin challenged and AEBSF/Dex treated mice.
Sagar Laxman Kale (315355), Sanjay Saw (315354), Naveen Arora (219782)   +2 more
core   +1 more source

Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation

Advanced Science, EarlyView.
Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan, Ting‐Hui Lee, Tzu‐Ning Peng, Eva Yi‐Hsuan Wu, Yu‐Ting Chiu, Chih‐Chien Chiu, Hong Vinh Nguyen, Yuan‐Shao Pao, Ming‐Hong Chao, Richard Kuan‐Lin Lee, Han‐Chung Wu, Lily Hui‐Ching Wang   +11 more
wiley   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source