Results 171 to 180 of about 264,068 (308)

The impact of pH on proteolytic activity in wound fluid: Implications for acid therapy. [PDF]

J Biol Chem
Barbosa da Silva E, Crane MJ, Liu L, Gelsinger DJ, Jordon ARD, Le P, Haggett JG, Myers SA, McKinney RL, Eberson CP, Jamieson AM, O'Donoghue AJ.   +11 more
europepmc   +1 more source

Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing. [PDF]

Int J Mol Sci, 2023
Wittner L, Wagener L, Wiese JJ, Stolzer I, Krug SM, Naschberger E, Jackstadt R, Beyaert R, Atreya R, Kühl AA, Sturm G, Gonzalez-Acera M, Patankar JV, Becker C, Siegmund B, Trajanoski Z, Winner B, Neurath MF, Schumann M, Günther C.   +19 more
europepmc   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

Gelatinase expression and proteolytic activity in giant-cell arteritis

Objectives: Gelatinases (MMP2 and MMP9) are expressed in giant-cell arteritis (GCA) and are thought to play a role in vessel disruption. However, their activation status and enzymatic activity have not been evaluated.
García Martínez, Ana, Lozano García, Ester, Grau Junyent, Josep M. (Josep Maria), Sánchez, Montse, Cid Xutglà, M. Cinta, Hernández Rodríguez, José, Segarra Blasco, Marta   +6 more
core  

Isolation of yeast nuclei. Evidence of chromatin-associated proteolytic activity.

, 1982
Purified yeast nuclei contain proteolytic activities which are associated with chromatin. pH optimum is in the range 8.0--8.5. Partial purification reveals the presence of three fractions corresponding to different molecular weights.
MAGNI, GIULIO, RUGGIERI, Silverio
core  

Potato Protein Suppresses Proteolytic Activity and Improves Textural Property of Tropical and Cold-Water Fish Surimi. [PDF]

Foods
Hamzeh A, Chumee S, Wilbrink MH, Spelbrink REJ, Laus MC, Yongsawatdigul J.   +5 more
europepmc   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Integrative computational, synthetic, experimental evaluation of targeted inhibitors against matrix metalloproteinase-9: Toward precision modulation of proteolytic activity. [PDF]

PLoS One
Rashid ZA, Sabbah DA, Sweidan K, Hajjo R, Bardaweel SK.   +4 more
europepmc   +1 more source

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

Features of revealing of proteolytic activity of provisional pathogenic microorganisms’ strains

, 2009
Features of revealing of proteolytic activity of provisional pathogenic microorganisms’ strains Conditions of manifestation of proteolytic activity by 12 hospital strains of microorganisms were studied with the use of some proteins-substrates, solvents ...
Пыжова, Н.С., Pyzhova, N.S., Nikandrov, V.N., Никандров, В.Н.   +3 more
core