Results 201 to 210 of about 416,903 (305)

Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS

Advanced Science, EarlyView.
ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi, Di Tang, Johan Malmström, Yasaman Karami, Hamed Khakzad   +4 more
wiley   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Passive Droplet Microfluidic Platform for High-Throughput Screening of Microbial Proteolytic Activity. [PDF]

Anal Chem
Potenza L, Kozon L, Drewniak L, Kaminski TS.   +3 more
europepmc   +1 more source

Proteolysis of defensive proteins in peritonitis exudate [PDF]

, 1991
Assfalg-Machleidt, Irmgard, Billing, A., Fröhlich, D., Jochum, Marianne, Machleidt, W.   +4 more
core   +1 more source

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

Cysteinyl leukotriene receptor 1 modulates retinal immune cells, vascularity and proteolytic activity in aged mice. [PDF]

Aging (Albany NY)
Koller A, Preishuber-Pflügl J, Mayr D, Brunner SM, Ladek AM, Runge C, Aigner L, Reitsamer HA, Trost A.   +8 more
europepmc   +1 more source

Neutrophil‐Mimetic Nanoscavengers Target the Inflammatory Microenvironment to Eliminate NETs/ROS and Immunomodulate cGAS‐STING Signaling in Septic AKI

Advanced Science, EarlyView.
Sepsis‐associated acute kidney injury is driven by oxidative stress, NETs overproduction, and dysregulated innate immunity. Here, we develop neutrophil‐mimetic nanoscavengers that integrate ROS‐scavenging Mn3O4 nanozymes with DNase‐1‐mediated NETs degradation to suppress cGAS‐STING signaling, reprogram macrophage polarization, and effectively alleviate
Zening Zhang, Chenxi Zhang, Ranran Luo, Qiuchi Wu, Pengchen Ren, Xinyu Liu, Yingying Luo, Zhongsheng Xu, Xiaojing He, Yun Liu   +9 more
wiley   +1 more source

Biosynthesis and assembly of mitochondrial proteins [PDF]

, 1983
A Scarpa, A Tzagoloff, AP Autor, AS Lewin, B Hennig, BC Pressman, C Côte, C Zwizinski, D Lloyd, DD Sabatini, DI Meyer, DI Meyer, DL Stigall, E Schmelzer, G Blobel, G Hallermayer, G Kreibich, G Macino, G Palade, G Schatz, G Schatz, GC Shore, H Freitag, H Freitag, H Korb, H Weiss, HW Heldt, J Subik, JG Conboy, JG Conboy, K Mihara, K Mihara, K Yamauchi, K Yamauchi, LAM Hensgens, M Klingenberg, M Mori, M Mori, M Schleyer, M Teintze, M-L Maccecchini, M-L Maccecchini, MA Harmey, N Nabi, N Nabi, N Nelson, N-H Chua, N-H Chua, P Böhni, P Sonderegger, P Sonderegger, P Walter, P Walter, P Walter, P Walter, PC Heinrich, PC Mcada, R Michel, R Sakakibara, R Zimmermann, R Zimmermann, R Zimmermann, R Zimmermann, RC Jackson, RN Dubois, S Matsuura, S Miura, SM Gasser, SN Graven, T Morita, W Neupert, W Sebald, W Wickner, Y Okada, Y Raymond, Y Raymond   +75 more
core   +1 more source

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

Preparation, Conformational Structure, and Proteolytic Activity of Papain Covalently Conjugated to Poly(ethylene glycol)-Tethered Lipid Bilayer Membranes. [PDF]

Biomacromolecules
Takahashi Y, Kubota K, Yoshimoto M, Yoshimoto N.   +3 more
europepmc   +1 more source