Results 91 to 100 of about 281,302 (344)

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Evaluation of encapsulated proteolytic enzymes from white shrimp (Litopenaeus vannamei) hepatopancreas for potential supplementation in tilapia feed

Food Chemistry Advances
This study aimed to evaluate the extraction, semi-purification, encapsulation, and release of proteolytic enzymes from the hepatopancreas of white shrimp (Litopenaeus vannamei) for potential inclusion in pelleted feed for tilapia.
Pablo Sergio Osuna-Amarillas, Kenia Yamileth Medina-Rivera, Martha Elisa Rivas-Vega, Francisco Javier Cinco-Moroyoqui, Octavio Cota-Arriola, Wilfrido Torres-Arriola, Norma Aurora Stephens-Camacho, Anselmo Miranda-Baeza   +7 more
doaj   +1 more source

Proteolysis sensitizes LDL particles to phospholipolysis by secretory phospholipase A2 group V and secretory sphingomyelinase

Journal of Lipid Research, 2010
LDL particles that enter the arterial intima become exposed to proteolytic and lipolytic modifications. The extracellular hydrolases potentially involved in LDL modification include proteolytic enzymes, such as chymase, cathepsin S, and plasmin, and ...
Riia Plihtari, Eva Hurt-Camejo, Katariina Öörni, Petri T. Kovanen   +3 more
doaj   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Protein-Rich Fraction of Cnidoscolus urens (L.) Arthur Leaves: Enzymatic Characterization and Procoagulant and Fibrinogenolytic Activities

Molecules, 2014
Proteolytic enzymes are important macromolecules in the regulation of biochemical processes in living organisms. Additionally, these versatile biomolecules have numerous applications in the industrial segment.
Yamara A. S. de Menezes, Juliana Félix-Silva, Arnóbio A. da Silva-Júnior, Ivanise M. M. Rebecchi, Adeliana S. de Oliveira, Adriana F. Uchoa, Matheus de F. Fernandes-Pedrosa   +6 more
doaj   +1 more source

Branched chain aldehydes: production and breakdown pathways and relevance for flavour in foods [PDF]

, 2009
Branched aldehydes, such as 2-methyl propanal and 2- and 3-methyl butanal, are important flavour compounds in many food products, both fermented and non-fermented (heat-treated) products. The production and degradation of these aldehydes from amino acids
Engels, W.J.M., Smit, B.A., Smit, G.
core   +2 more sources

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Changes in proteolitic activity of digestive system of Beluga sturgeon, Huso huso during larval ontogeny [PDF]

تغذیه آبزیان, 2015
The development of proteolysis digestive enzymes from the stomach and pancreas were studied in Beluga, Huso huso from hatching up to 50th day post hatching (dph).
Reza Asgari, Soheil Eagderi, Gholamreza Rafiee, Hadi Poorbagher, Naser Agh   +4 more
doaj  

EKSTRAKSI DAN KARAKTERISASI PARSIAL EKSTRAK KASAR ENZIM KATEPSIN DARI IKAN PATIN [Extraction and Partial Characterization of Crude Enzymes Cathepsin from Catfish]

Jurnal Teknologi dan Industri Pangan, 2014
Decomposition of protein by enzymatic process will lead to changes in odor, texture, and appearance of fish. The enzymes that play a role in the enzymatic process is primarily proteolytic enzymes.
Muhammad Zakiyul Fikri*, Tati Nurhayati , Ella Salamah   +2 more
doaj   +1 more source

Therapeutic Targeting of the Proteolytic Enzymes. [PDF]

Int J Mol Sci, 2022
Couture F.
europepmc   +1 more source