Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics
Advanced Healthcare Materials, EarlyView.A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins +3 more
wiley +1 more source
The effect of proteolytic enzymes on the troponin complex [PDF]
, 1971 W. Drabikowski +4 more
openalex +1 more source
Inhibition of Protease Activity in Muscle Extracts and Surimi from Pacific Whiting, Merluccius productus, and Arrowtooth Flounder, Atheresthes stomias [PDF]
, 1993 Muscle extracts of Pacific whiting, Merluccius productus, and arrowtooth flounder, Atheresthes stomias, were assayed for proteolytic activity using azocasein as a substrate. Pacific whiting extracts showed maximum activity at pH 5.0-5.2 and a temperature
Koury, Barbara +2 more
core
The endogenous production of hydrogen sulphide in intrauterine tissues [PDF]
, 2009 Background: Hydrogen sulphide is a gas signalling molecule which is produced endogenously from L-cysteine via the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).
Carson, Ray J. +4 more
core +5 more sources
Isolation Defines Identity: Functional Consequences of Extracellular Vesicle Purification Strategies
Advanced Healthcare Materials, EarlyView.Four extracellular vesicle purification strategies are compared using ovarian‐cancer ascites and ES‐2 cell supernatants. A novel workflow links purification to function by combining particle‐normalized proteomics with matched cell‐free and cell‐based assays.
Christian Preußer +10 more
wiley +1 more source
Proteolytic enzymes in adenocarcinomata of the human colon. [PDF]
, 1969 David M. Goldberg +2 more
openalex +1 more source
Advanced Materials, EarlyView.A 3D‐printed BSA–PEGDA bilayer actuator performs biochemical logic, bending autonomously in acid and releasing its drug payload only when both acid and pepsin are present. This dual‐stage, enzyme‐gated mechanism enables autonomous catch‐and‐release motion and controlled gastric drug delivery, representing a programmable soft material powered by ...
Yuchen Liu +3 more
wiley +1 more source
Comparative Analysis of the Alkaline Proteolytic Enzymes of Yarrowia Clade Species and Their Putative Applications. [PDF]
Int J Mol Sci, 2023 Ciurko D +4 more
europepmc +1 more source
Advanced Materials Interfaces, EarlyView.Conductive silk‐polypyrrole scaffolds couple redox stability with cell‐affinitive peptides present innately in an endogenous silk fibroin, enabling optimized electrical stimulation to drive neurite outgrowth. Findings establish electrochemical‐biological link for biomaterial design rules for smart nerve guidance conduits that can provide low voltage ...
Rajiv Borah +5 more
wiley +1 more source
Screening of protease-producing bacteria from fermented shrimp products (terasi) for meat tenderization [PDF]
BIO Web of ConferencesTerasi is a traditional fermented product that is popularly used as condiment in several Indonesian cuisines. Based on its raw materials, namely shrimp and marine fish, terasi provides a substrate for various protease-producing microorganisms. This study
Handayani Rini +4 more
doaj +1 more source