Results 231 to 240 of about 281,302 (344)

Relationship between circulating levels of pancreatic proteolytic enzymes and pancreatic hormones. [PDF]

Pancreatology, 2017
Bharmal SH, Pendharkar SA, Singh RG, Goodarzi MO, Pandol SJ, Petrov MS.   +5 more
europepmc   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Effect of Proteolytic Enzymes and Ginger Extract on Tenderization of M. pectoralis profundus from Holstein Steer. [PDF]

Korean J Food Sci Anim Resour, 2018
Moon SS.
europepmc   +1 more source

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Degradation of myofibrillar, sarcoplasmic and connective tissue proteins by plant proteolytic enzymes and their impact on camel meat tenderness. [PDF]

J Food Sci Technol, 2018
Maqsood S, Manheem K, Gani A, Abushelaibi A.   +3 more
europepmc   +1 more source

Porosity of the cell wall as related to the Secretion of proteolytic enzymes in N. crassa

, 1967
Ph. Matile
openalex   +2 more sources

Bioorthogonal Sonodynamic Plug‐and‐Play Targeting Chimeras (SDPTAC) for Precise Targeted Protein Degradation

Advanced Science, EarlyView.
Bioorthogonal SDPTAC harnesses US‐responsive Ce6‐TCO and Tz ligands via IEDDA click chemistry to assemble degraders in situ, generating ROS that selectively eliminate nuclear, cytosolic, and membrane proteins, thereby suppressing deep‐seated tumors in vivo.
Yuhan Bao, Yaojin Zhu, Xinhao Wei, Yuxin Fang, Jiayi Zhu, Fei Gao, Guoqiang Dong, Shipeng He, Chunquan Sheng   +8 more
wiley   +1 more source

The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database. [PDF]

Nucleic Acids Res, 2018
Rawlings ND, Barrett AJ, Thomas PD, Huang X, Bateman A, Finn RD.   +5 more
europepmc   +1 more source

Disturbances of selected plasma proteins in Hyperdynamic Septic Shock [PDF]

, 1982
A Ledgerwood, AO Aasen, AO Aasen, CB Laurell, D Collen, DL Heene, DM Rangel, EA Friedmann, EF Gersmeyer, FW Putnam, H Fritz, H Graeff, H Schiessler, H. Fritz, HG Lasch, J Johnson, J. Witte, JW Alexander, K Havemann, K Hochstrasser, K Messmer, K Ohlsson, K. Hochstrasser, M Jochum, M Jochum, M. Jochum, MS Losowsky, N Freudenberg, P Skansberg, PJ Hamilton, PM Starkey, R Dielt, R Egbring, R Hafter, R. Scherer, RG Lerner, W Schramm, W Schramm, W. Schramm   +38 more
core   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source