Results 301 to 310 of about 2,254,706 (376)

Resolution of distinct steps in mitochondrial protein import [PDF]

, 1988
Bradshaw, Ralph A., Douglas, M. G., Hartl, Franz-Ulrich, McAlister-Henn, L., Neupert, Walter, Pfanner, Nikolaus   +5 more
core  

Development of an efficient mice model of cancer‐associated cardiac cachexia

Animal Models and Experimental Medicine, EarlyView.
This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong, Huiting Zheng, Teng Wu, Jing Tan, Tongsheng Huang, Conghui Shen, Yuanjun Ji, Mengying Liu, Junhong Wan, Weibin Cai   +9 more
wiley   +1 more source

Development, validation, and preliminary phenotypic characterization of a Col6a3 knockout mouse model targeting exon 3

Animal Models and Experimental Medicine, EarlyView.
Deleting Col6a3 exon 3 by CRISPR in mice results in centralized nuclei consistent with a myopathy phenotype mimicking collagen VI‐associated human disease Abstract Background Most mutations in the COL6A3 gene lead to collagen VI‐related myopathies. This is due to a reduced expression or mislocalization of the COL6A3 protein.
Michel ElChoueiry, Harsimran Sidhu, Maude Lévesque, Dominique Lévesque, Jean‐François Jacques, Otman Sarrhini, Jean‐François Beaudoin, Molly Caron, Brenda Gaudette, Roger Lecomte, Xavier Roucou, François‐Michel Boisvert, Jean‐Philippe Brosseau   +12 more
wiley   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

Stability and Release Characteristics of Core‐Shell Beads with Emulsion Core Under Gastrointestinal Conditions

Advanced NanoBiomed Research, EarlyView.
A combined emulsion–core‐shell structure system is developed for targeted delivery of lipophilic compounds to the proximal intestine. Using vitamin D3‐loaded sunflower oil emulsions, the core‐shell structure enhances droplet stability, encapsulation efficiency, and gastric protection.
Fariba Malekpour Galogahi, Haotian Cha, Lingxi Ouyang, Nam‐Trung Nguyen   +3 more
wiley   +1 more source

Proteolytic <i>Bacillus</i> sp. Isolation and Identification from Tannery Alkaline Baths. [PDF]

Molecules
Lageiro M, Simões F, Alvarenga N, Reis A.   +3 more
europepmc   +1 more source

Peptide/Antibody–Drug Conjugates for Therapeutic Applications in Inflammatory Disease

Advanced NanoBiomed Research, EarlyView.
Peptide/antibody–drug conjugates (PADCs) combine ligand specificity and cleavable linkers to deliver drugs precisely to disease sites with minimal toxicity. While current approvals focus on oncology, this review examines their untapped potential in inflammatory diseases, detailing mechanisms of targeted delivery and highlighting advances that position ...
Yeongji Jang, Jiwoong Choi, Youngri Ryu, Hyun Kyu Song, Man Kyu Shim, Yoosoo Yang   +5 more
wiley   +1 more source

Identifying protease-activated targets and exploring therapeutic applications. [PDF]

Expert Opin Ther Targets
Kang D, Craik CS.
europepmc   +1 more source

Solvent‐ and Energy‐Free Solid‐State Strategy for Enzyme Encapsulation in ZIF

Angewandte Chemie, EarlyView.
A solvent‐ and energy‐free solid‐state strategy is developed for synthesizing enzyme@ZIF biocomposites by directly mixing enzymes with ZIF precursors. Driven by acid–base interactions, the resulting biocomposites show enhanced activity due to multiphase crystalline structure, larger surface area, better electron transfer, and favorable enzyme ...
Zefang Yu, Bernt Johannessen, Ming Zhang, Hongyu Shi, Yanhan Wang, Yu Wang, Jun Ge, Kang Liang, Jieying Liang   +8 more
wiley   +1 more source

Neutrophil activity compromises root caries remineralization and alters caries-affected-like dentin. [PDF]

Clin Oral Investig
Trivedi RK, Patel RH, Wazir A, Zamperini CA.   +3 more
europepmc   +1 more source