Results 271 to 280 of about 115,149 (302)
Some of the next articles are maybe not open access.
2023
AbstractCommon and rare variants in theLRRK2locus are associated with Parkinson’s disease (PD) risk, but the downstream effects of these variants on protein levels remains unknown. We performed comprehensive proteogenomic analyses using the largest aptamer-based CSF proteomics study to date (7,006 aptamers (6,138 unique proteins) in 3,107 individuals).
Bridget Phillips +25 more
openaire +1 more source
AbstractCommon and rare variants in theLRRK2locus are associated with Parkinson’s disease (PD) risk, but the downstream effects of these variants on protein levels remains unknown. We performed comprehensive proteogenomic analyses using the largest aptamer-based CSF proteomics study to date (7,006 aptamers (6,138 unique proteins) in 3,107 individuals).
Bridget Phillips +25 more
openaire +1 more source
Cancer Research
Abstract Background: Genome-wide association studies (GWAS) have identified over 200 breast cancer risk associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive. Proteins, as final gene products, are pivotal in cellular function.
Tianying Zhao +10 more
openaire +1 more source
Abstract Background: Genome-wide association studies (GWAS) have identified over 200 breast cancer risk associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive. Proteins, as final gene products, are pivotal in cellular function.
Tianying Zhao +10 more
openaire +1 more source
Proteome-Wide and Transcriptome-Wide Association Studies of Kidney Function
Journal of the American Society of Nephrology, 2021Pascal Schlosser +10 more
openaire +1 more source
New Etiological Insights of Psychiatric Disorders by Proteome-wide Association Study
Biological Psychiatry, 2021openaire +2 more sources
The Journal of Clinical Endocrinology & Metabolism
Abstract The pathophysiological mechanisms underlying type 2 diabetes mellitus (T2DM) remain incompletely understood, and the disease continues to impose a substantial burden on global health. In this study, we integrated the data from the largest genome-wide association study (GWAS; N = 898 130) of T2DM with human plasma protein ...
Yang Yang +9 more
openaire +1 more source
Abstract The pathophysiological mechanisms underlying type 2 diabetes mellitus (T2DM) remain incompletely understood, and the disease continues to impose a substantial burden on global health. In this study, we integrated the data from the largest genome-wide association study (GWAS; N = 898 130) of T2DM with human plasma protein ...
Yang Yang +9 more
openaire +1 more source
Intermittent fasting in the prevention and treatment of cancer
Ca-A Cancer Journal for Clinicians, 2021Katherine Clifton +2 more
exaly
An overview of real‐world data sources for oncology and considerations for research
Ca-A Cancer Journal for Clinicians, 2022Lynne Penberthy +2 more
exaly
Social determinants of health and US cancer screening interventions: A systematic review
Ca-A Cancer Journal for Clinicians, 2023Ariella R Korn
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