Results 251 to 260 of about 114,169 (274)

New Etiological Insights of Psychiatric Disorders by Proteome-wide Association Study

Biological Psychiatry, 2021
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Blood Plasma Proteome-Wide Association Study Implicates New Proteins in Type 2 Diabetes Mellitus Pathogenesis

The Journal of Clinical Endocrinology & Metabolism
Abstract The pathophysiological mechanisms underlying type 2 diabetes mellitus (T2DM) remain incompletely understood, and the disease continues to impose a substantial burden on global health. In this study, we integrated the data from the largest genome-wide association study (GWAS; N = 898 130) of T2DM with human plasma protein ...
Yang Yang, Jia-Hao Wang, Hao-An Wang, Tian-Pei Zhang, Guanchen Liu, Shan-Shan Dong, Tie-Lin Yang, Wei Chen, Ruo-Han Hao, Yan Guo   +9 more
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Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies

Nature Genetics, 2022
Jingning Zhang, Diptavo Dutta, Anna Köttgen   +2 more
exaly  

Human Brain Proteome-Wide Association Study Implicates Potential Therapeutic Targets for Obesity

2023
Qigang Zhao, Xin-Ling Ma, Qian Xu, Zi-Tong Song, Fan Bu, Kuan Li, Lei Zhang, YuFang Pei   +7 more
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Large-scale integration of the plasma proteome with genetics and disease

Nature Genetics, 2021
Egil Ferkingstad, Patrick Sulem, Gardar Sveinbjornsson   +2 more
exaly  

F14. PROTEOME WIDE ASSOCIATION STUDY OF MAJOR DEPRESSIVE DISORDER, SCHIZOPHRENIA, AND BIPOLAR DISORDER

European Neuropsychopharmacology, 2023
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F94. Human Brain Proteome-Wide Association Study of Longitudinally Assessed Late-Life Depression

Biological Psychiatry, 2019
Aliza Wingo, Wen Fan, Nicholas Seyfried, Duc Duong, Eric Dammer, David Bennett, James Lah, Allan Levey, Thomas Wingo   +8 more
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Causal associations between COVID-19 and diseases of seven organs: A proteome-wide Mendelian randomization study

The coronavirus disease 2019 (COVID-19) pandemic poses an enormous threat to public health worldwide. Many retrospective studies and case reports to date have shown associations between severe COVID-19 and multi-organs. However, the research on the causal mechanisms behind this phenomenon is neither extensive nor comprehensive.
Yunhan Shen, Yi Zhang, Ye-yang Xu, Xinyi Li, Jiachen Wu, Hao Pei, Linyan Wang, Tiansheng Zhu   +7 more
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Generating and navigating proteome maps using mass spectrometry

Nature Reviews Molecular Cell Biology, 2010
Christian H Ahrens, Erich Brunner, Ermir Qeli   +2 more
exaly  

Integrative analysis of Transcriptome-wide and Proteome-wide association study for non-Mendelian disorders

Genome-wide association studies (GWAS) have uncovered numerous variants linked to a wide range of complex traits. However, understanding the mechanisms underlying these associations remains a challenge. To determine genetically regulated mechanisms, additional layers of gene regulation, such as transcriptome and proteome, need to be assayed ...
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