Results 1 to 10 of about 1,048,514 (164)

TXNDC12 and GDF2 as genetically supported plasma proteins associated with knee osteoarthritis: evidence from Mendelian randomization and preliminary biological support [PDF]

Frontiers in Medicine
BackgroundPrimary knee osteoarthritis (PKOA) is a common degenerative joint disease lacking effective disease-modifying therapies. Identifying circulating proteins associated with PKOA may provide clues for therapeutic target discovery.MethodsA two ...
Xiangyu Hu, Xiangyu Hu, Hao Rao, Li Luo, Shuang Tao, Gang Wu, Gang Wu, Hanqiao Sun, Chao Li   +8 more
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Plasma Proteins and Cancer [PDF]

Cancers, 2021
The human plasma comes into contact with virtually all the cells in the human body and can be easily sampled through phlebotomy [...]
openaire   +3 more sources

INSTIGO Trial: Evaluation of a Plasma Protein Profile as a Predictive Biomarker for Metastatic Relapse of Triple Negative Breast Cancer

Frontiers in Oncology, 2021
BackgroundTriple negative breast cancer (TNBC) accounts for 10-20% of breast cancers but has no specific therapy. While TNBC may be more sensitive to chemotherapy than other types of breast cancer, it has a poor prognosis. Most TNBC relapses occur during
Hugo Veyssière, Hugo Veyssière, Hugo Veyssière, Sejdi Lusho, Sejdi Lusho, Sejdi Lusho, Ioana Molnar, Ioana Molnar, Ioana Molnar, Myriam Kossai, Myriam Kossai, Maureen Bernadach, Maureen Bernadach, Catherine Abrial, Catherine Abrial, Catherine Abrial, Yannick Bidet, Yannick Bidet, Nina Radosevic-Robin, Nina Radosevic-Robin, Xavier Durando, Xavier Durando, Xavier Durando   +22 more
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Factor VIII/V C-domain swaps reveal discrete C-domain roles in factor VIII function and intracellular trafficking

Haematologica, 2017
Factor VIII C-domains are believed to have specific functions in cofactor activity and in interactions with von Willebrand factor. We have previously shown that factor VIII is co-targeted with von Willebrand factor to the Weibel-Palade bodies in blood ...
Eduard H.T.M. Ebberink, Eveline A.M. Bouwens, Esther Bloem, Mariëtte Boon-Spijker, Maartje van den Biggelaar, Jan Voorberg, Alexander B. Meijer, Koen Mertens   +7 more
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Spectroscopic and Theoretical Analysis of the Interaction between Plasma Proteins and Phthalimide Analogs with Potential Medical Application

Life, 2023
One of the groups of organic compounds with potential use in medicine and pharmacy is phthalimide derivatives. They are characterized by a wide range of properties such as antibacterial, antifungal, and anti-inflammatory.
Edward Krzyżak, Aleksandra Kotynia, Dominika Szkatuła, Aleksandra Marciniak   +3 more
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von Willebrand factor binds to the surface of dendritic cells and modulates peptide presentation of factor VIII

Haematologica, 2016
It has been proposed that von Willebrand factor might affect factor VIII immunogenicity by reducing factor VIII uptake by antigen presenting cells. Here we investigate the interaction of recombinant von Willebrand factor with immature monocyte-derived ...
Nicoletta Sorvillo, Robin B. Hartholt, Esther Bloem, Magdalena Sedek, Anja ten Brinke, Carmen van der Zwaan, Floris P. van Alphen, Alexander B. Meijer, Jan Voorberg   +8 more
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The plasma proteins and their fractionation [PDF]

Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie, 1947
The large scale fractionation of the pro teins of blood plasma was direct1y a product of the needs of military medicine in the United States during the war. Fundamentally, however, this development rests on a long series of advances in protein chemistry which have occurred over the last forty years in many laboratories, notably in England, Scandinavia,
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Emerging Concepts in Immune Thrombocytopenia

Frontiers in Immunology, 2018
Immune thrombocytopenia (ITP) is an autoimmune disease defined by low platelet counts which presents with an increased bleeding risk. Several genetic risk factors (e.g., polymorphisms in immunity-related genes) predispose to ITP.
Maurice Swinkels, Maaike Rijkers, Jan Voorberg, Gestur Vidarsson, Frank W. G. Leebeek, A. J. Gerard Jansen, A. J. Gerard Jansen   +6 more
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Spectroscopic Studies of Quinobenzothiazine Derivative in Terms of the In Vitro Interaction with Selected Human Plasma Proteins. Part 1

Molecules, 2021
Plasma proteins play a fundamental role in living organisms. They participate in the transport of endogenous and exogenous substances, especially drugs.
Aleksandra Owczarzy, Andrzej Zięba, Jadwiga Pożycka, Karolina Kulig, Wojciech Rogóż, Agnieszka Szkudlarek, Małgorzata Maciążek-Jurczyk   +6 more
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Comparative profiling of HLA-DR and HLA-DQ associated factor VIII peptides presented by monocyte-derived dendritic cells

Haematologica, 2018
The development of anti-factor VIII antibodies is a major complication of the treatment of patients with hemophilia A. Generation of high affinity anti-factor VIII antibodies is dependent on help provided by CD4+ T cells that recognize factor VIII ...
Ivan Peyron, Robin B. Hartholt, Laura Pedró-Cos, Floris van Alphen, Anja ten Brinke, Neubury Lardy, Alexander B. Meijer, Jan Voorberg   +7 more
doaj   +1 more source