Results 11 to 20 of about 1,013,457 (265)

Molecular Mechanisms of the Interactions of N-(2-Hydroxypropyl)methacrylamide Copolymers Designed for Cancer Therapy with Blood Plasma Proteins

Pharmaceutics, 2020
The binding of plasma proteins to a drug carrier alters the circulation of nanoparticles (NPs) in the bloodstream, and, as a consequence, the anticancer efficiency of the entire nanoparticle drug delivery system.
Larisa Janisova, Andrey Gruzinov, Olga V. Zaborova, Nadiia Velychkivska, Ondřej Vaněk, Petr Chytil, Tomáš Etrych, Olga Janoušková, Xiaohan Zhang, Clement Blanchet, Christine M. Papadakis, Dmitri I. Svergun, Sergey K. Filippov   +12 more
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Plasma Protein Levels Analysis in Multiple Sclerosis Sardinian Families Identified C9 and CYP24A1 as Candidate Biomarkers

Life, 2022
Here we investigate protein levels in 69 multiple sclerosis (MS) cases and 143 healthy controls (HC) from twenty Sardinian families to search for promising biomarkers in plasma.
Andrea Nova, Teresa Fazia, Ashley Beecham, Valeria Saddi, Marialuisa Piras, Jacob L. McCauley, Carlo Berzuini, Luisa Bernardinelli   +7 more
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The class I scavenger receptor CD163 promotes internalization of ADAMTS13 by macrophages

Blood Advances, 2017
: Internalization of ADAMTS13 by macrophages may contribute to its clearance from the circulation. Here we investigated endocytic mechanisms that contribute to the uptake of ADAMTS13 by macrophages. Human monocyte-derived macrophages were used to monitor
Fabian C. Verbij, Nicoletta Sorvillo, Paul H.P. Kaijen, Johana Hrdinova, Ivan Peyron, Rob Fijnheer, Anja ten Brinke, Alexander B. Meijer, Floris P.J. van Alphen, Timo K. van den Berg, Jonas J.H. Graversen, Soren K. Moestrup, Jan Voorberg   +12 more
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Determining Plasma Protein Variation Parameters as a Prerequisite for Biomarker Studies—A TMT-Based LC-MSMS Proteome Investigation

Proteomes, 2021
Specific plasma proteins serve as valuable markers for various diseases and are in many cases routinely measured in clinical laboratories by fully automated systems.
Lou-Ann C. Andersen, Nicolai Bjødstrup Palstrøm, Axel Diederichsen, Jes Sanddal Lindholt, Lars Melholt Rasmussen, Hans Christian Beck   +5 more
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Recombinant plasma proteins [PDF]

Vox Sanguinis, 2010
For almost 50 years, the fractionation of human plasma has been the sole possible source of a wide range of therapeutic proteins–such as coagulation factors, anticoagulants, immunoglobulins, and albumin – essential to the treatment of serious congenital or acquired bleeding or immunological diseases. In the last 20 years, the application of recombinant
openaire   +2 more sources

Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ

Haematologica, 2018
Formation of microthrombi is a hallmark of acquired thrombotic thrombocytopenic purpura. These microthrombi originate from insufficient processing of ultra large von Willebrand factor multimers by ADAMTS13 due to the development of anti-ADAMTS13 ...
Johana Hrdinová, Fabian C. Verbij, Paul H.P. Kaijen, Robin B. Hartholt, Floris van Alphen, Neubury Lardy, Anja ten Brinke, Karen Vanhoorelbeke, Pooja J. Hindocha, Anne S. De Groot, Alexander B. Meijer, Jan Voorberg, Ivan Peyron   +12 more
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Label-free Analysis of CD8+ T Cell Subset Proteomes Supports a Progressive Differentiation Model of Human-Virus-Specific T Cells

Cell Reports, 2017
Summary: Pathogens trigger T cells to express distinct sets of effector proteins. To better understand the molecular mechanisms that drive functional specification, we used high-resolution mass spectrometry and label-free protein quantification to ...
Michiel C. van Aalderen, Maartje van den Biggelaar, Ester B.M. Remmerswaal, Floris P.J. van Alphen, Alexander B. Meijer, Ineke J.M. ten Berge, René A.W. van Lier   +6 more
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A subset of anti-HLA antibodies induces FcγRIIa-dependent platelet activation

Haematologica, 2018
HLA antibodies are associated with refractoriness to platelet transfusion, leading to rapid platelet clearance, sometimes coinciding with clinical side effects such as fever and chills.
Maaike Rijkers, Anno Saris, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Ruben Bierings, Frank W.G. Leebeek, A.J. Gerard Jansen, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +11 more
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Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers

Haematologica, 2018
Although outstanding progress has been made in understanding the pathophysiology of thrombotic thrombocytopenic purpura (TTP), knowledge of the immunopathogenesis of the disease is only at an early stage. Anti-ADAMTS13 auto-antibodies were shown to block
Johana Hrdinová, Silvia D’Angelo, Nuno A. G. Graça, Bogac Ercig, Karen Vanhoorelbeke, Agnès Veyradier, Jan Voorberg, Paul Coppo   +7 more
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Molecular signature of methotrexate response among rheumatoid arthritis patients

Frontiers in Medicine, 2023
BackgroundMethotrexate (MTX) is the first line treatment for rheumatoid arthritis (RA), but failure of satisfying treatment response occurs in a significant proportion of patients.
Boel Brynedal, Boel Brynedal, Niyaz Yoosuf, Niyaz Yoosuf, Niyaz Yoosuf, Tinna Bjorg Ulfarsdottir, Daniel Ziemek, Mateusz Maciejewski, Lasse Folkersen, Helga Westerlind, Helga Westerlind, Malin Müller, Malin Müller, Peter Sahlström, Peter Sahlström, Scott A. Jelinsky, Aase Hensvold, Aase Hensvold, Aase Hensvold, Leonid Padyukov, Leonid Padyukov, Nancy Vivar Pomiano, Nancy Vivar Pomiano, Anca Catrina, Anca Catrina, Lars Klareskog, Lars Klareskog, Louise Berg, Louise Berg   +28 more
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