Results 11 to 20 of about 1,632,079 (301)

Emerging Concepts in Immune Thrombocytopenia

Frontiers in Immunology, 2018
Immune thrombocytopenia (ITP) is an autoimmune disease defined by low platelet counts which presents with an increased bleeding risk. Several genetic risk factors (e.g., polymorphisms in immunity-related genes) predispose to ITP.
Maurice Swinkels, Maaike Rijkers, Jan Voorberg, Gestur Vidarsson, Frank W. G. Leebeek, A. J. Gerard Jansen, A. J. Gerard Jansen   +6 more
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Spectroscopic Studies of Quinobenzothiazine Derivative in Terms of the In Vitro Interaction with Selected Human Plasma Proteins. Part 1

Molecules, 2021
Plasma proteins play a fundamental role in living organisms. They participate in the transport of endogenous and exogenous substances, especially drugs.
Aleksandra Owczarzy, Andrzej Zięba, Jadwiga Pożycka, Karolina Kulig, Wojciech Rogóż, Agnieszka Szkudlarek, Małgorzata Maciążek-Jurczyk   +6 more
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Recombinant plasma proteins [PDF]

Vox Sanguinis, 2010
For almost 50 years, the fractionation of human plasma has been the sole possible source of a wide range of therapeutic proteins–such as coagulation factors, anticoagulants, immunoglobulins, and albumin – essential to the treatment of serious congenital or acquired bleeding or immunological diseases. In the last 20 years, the application of recombinant
openaire   +2 more sources

Comparative profiling of HLA-DR and HLA-DQ associated factor VIII peptides presented by monocyte-derived dendritic cells

Haematologica, 2018
The development of anti-factor VIII antibodies is a major complication of the treatment of patients with hemophilia A. Generation of high affinity anti-factor VIII antibodies is dependent on help provided by CD4+ T cells that recognize factor VIII ...
Ivan Peyron, Robin B. Hartholt, Laura Pedró-Cos, Floris van Alphen, Anja ten Brinke, Neubury Lardy, Alexander B. Meijer, Jan Voorberg   +7 more
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Molecular Mechanisms of the Interactions of N-(2-Hydroxypropyl)methacrylamide Copolymers Designed for Cancer Therapy with Blood Plasma Proteins

Pharmaceutics, 2020
The binding of plasma proteins to a drug carrier alters the circulation of nanoparticles (NPs) in the bloodstream, and, as a consequence, the anticancer efficiency of the entire nanoparticle drug delivery system.
Larisa Janisova, Andrey Gruzinov, Olga V. Zaborova, Nadiia Velychkivska, Ondřej Vaněk, Petr Chytil, Tomáš Etrych, Olga Janoušková, Xiaohan Zhang, Clement Blanchet, Christine M. Papadakis, Dmitri I. Svergun, Sergey K. Filippov   +12 more
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Plasma Protein Levels Analysis in Multiple Sclerosis Sardinian Families Identified C9 and CYP24A1 as Candidate Biomarkers

Life, 2022
Here we investigate protein levels in 69 multiple sclerosis (MS) cases and 143 healthy controls (HC) from twenty Sardinian families to search for promising biomarkers in plasma.
Andrea Nova, Teresa Fazia, Ashley Beecham, Valeria Saddi, Marialuisa Piras, Jacob L. McCauley, Carlo Berzuini, Luisa Bernardinelli   +7 more
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The class I scavenger receptor CD163 promotes internalization of ADAMTS13 by macrophages

Blood Advances, 2017
: Internalization of ADAMTS13 by macrophages may contribute to its clearance from the circulation. Here we investigated endocytic mechanisms that contribute to the uptake of ADAMTS13 by macrophages. Human monocyte-derived macrophages were used to monitor
Fabian C. Verbij, Nicoletta Sorvillo, Paul H.P. Kaijen, Johana Hrdinova, Ivan Peyron, Rob Fijnheer, Anja ten Brinke, Alexander B. Meijer, Floris P.J. van Alphen, Timo K. van den Berg, Jonas J.H. Graversen, Soren K. Moestrup, Jan Voorberg   +12 more
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Determining Plasma Protein Variation Parameters as a Prerequisite for Biomarker Studies—A TMT-Based LC-MSMS Proteome Investigation

Proteomes, 2021
Specific plasma proteins serve as valuable markers for various diseases and are in many cases routinely measured in clinical laboratories by fully automated systems.
Lou-Ann C. Andersen, Nicolai Bjødstrup Palstrøm, Axel Diederichsen, Jes Sanddal Lindholt, Lars Melholt Rasmussen, Hans Christian Beck   +5 more
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Cellular mechanisms for cargo delivery and polarity maintenance at different polar domains in plant cells [PDF]

, 2016
The asymmetric localization of proteins in the plasma membrane domains of eukaryotic cells is a fundamental manifestation of cell polarity that is central to multicellular organization and developmental patterning.
Friml, Jiri, Langowski, Lukasz, Li, Hongjiang, Naramoto, Satoshi, Tanaka, Hirokazu, Vanneste, Steffen, Wabnik, Krzysztof   +6 more
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Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ

Haematologica, 2018
Formation of microthrombi is a hallmark of acquired thrombotic thrombocytopenic purpura. These microthrombi originate from insufficient processing of ultra large von Willebrand factor multimers by ADAMTS13 due to the development of anti-ADAMTS13 ...
Johana Hrdinová, Fabian C. Verbij, Paul H.P. Kaijen, Robin B. Hartholt, Floris van Alphen, Neubury Lardy, Anja ten Brinke, Karen Vanhoorelbeke, Pooja J. Hindocha, Anne S. De Groot, Alexander B. Meijer, Jan Voorberg, Ivan Peyron   +12 more
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