Results 31 to 40 of about 4,009,281 (300)

Counting the Proteins in Plasma [PDF]

Clinical Chemistry, 2010
Featured Article: Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, et al. The human plasma proteome: a non-redundant list developed by combination of four separate sources. Mol Cell Proteomics 2004;3:311–26.2 The problem of enumerating protein components in plasma has challenged the best analytical technologies for more than 80 ...
openaire   +2 more sources

Secretory vesicles are preferentially targeted to areas of low molecular SNARE density [PDF]

, 2012
Intercellular communication is commonly mediated by the regulated fusion, or exocytosis, of vesicles with the cell surface. SNARE (soluble N-ethymaleimide sensitive factor attachment protein receptor) proteins are the catalytic core of the secretory ...
Weiping Lu (120665), Dun, Alison R., Lu, Weiping, Rory R. Duncan (120667), Weiping Lu, Gabriel J. Lord (120664), Colin Rickman (120669), Andrew Dunn, Gabriel J Lord, Martin, Kirsty J, Lei Yang (102719), Qiu, Zhen, Rickman, Colin; id_orcid, Kirsty J Martin, Lei Yang, Duncan, Rory R, Duncan, Rory R., Alison R. Dun (120660), Zhen Qiu (120662), Rickman, Colin, Dun, Alison, Qiu, Zhen; id_orcid, Colin Rickman, Rory R Duncan, Lord, Gabriel J, Kirsty J. Martin (120661), Alison R Dun, Lord, Gabriel J., Yang, Lei, Martin, Kirsty J., Andrew Dunn (120663), Dunn, Andrew, Zhen Qiu, Martin Kirsty J., Yang Lei, Duncan Rory R., Dun Alison R., Dunn Andrew, Rickman Colin, Qiu Zhen, Lu Weiping, Lord Gabriel J.   +41 more
core   +1 more source

Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers

Haematologica, 2018
Although outstanding progress has been made in understanding the pathophysiology of thrombotic thrombocytopenic purpura (TTP), knowledge of the immunopathogenesis of the disease is only at an early stage. Anti-ADAMTS13 auto-antibodies were shown to block
Johana Hrdinová, Silvia D’Angelo, Nuno A. G. Graça, Bogac Ercig, Karen Vanhoorelbeke, Agnès Veyradier, Jan Voorberg, Paul Coppo   +7 more
doaj   +1 more source

Molecular signature of methotrexate response among rheumatoid arthritis patients

Frontiers in Medicine, 2023
BackgroundMethotrexate (MTX) is the first line treatment for rheumatoid arthritis (RA), but failure of satisfying treatment response occurs in a significant proportion of patients.
Boel Brynedal, Boel Brynedal, Niyaz Yoosuf, Niyaz Yoosuf, Niyaz Yoosuf, Tinna Bjorg Ulfarsdottir, Daniel Ziemek, Mateusz Maciejewski, Lasse Folkersen, Helga Westerlind, Helga Westerlind, Malin Müller, Malin Müller, Peter Sahlström, Peter Sahlström, Scott A. Jelinsky, Aase Hensvold, Aase Hensvold, Aase Hensvold, Leonid Padyukov, Leonid Padyukov, Nancy Vivar Pomiano, Nancy Vivar Pomiano, Anca Catrina, Anca Catrina, Lars Klareskog, Lars Klareskog, Louise Berg, Louise Berg   +28 more
doaj   +1 more source

Stiffness-Induced Endothelial DLC-1 Expression Forces Leukocyte Spreading through Stabilization of the ICAM-1 Adhesome

Cell Reports, 2018
Summary: Leukocytes follow the well-defined steps of rolling, spreading, and crawling prior to diapedesis through endothelial cells (ECs). We found increased expression of DLC-1 in stiffness-associated diseases like atherosclerosis and pulmonary arterial
Lilian Schimmel, Miesje van der Stoel, Carmela Rianna, Anne-Marieke van Stalborch, Aafke de Ligt, Mark Hoogenboezem, Simon Tol, Jos van Rijssel, Robert Szulcek, Harm Jan Bogaard, Patrick Hofmann, Reinier Boon, Manfred Radmacher, Vivian de Waard, Stephan Huveneers, Jaap D. van Buul   +15 more
doaj   +1 more source

Barley plasma membrane intrinsic proteins (PIP aquaporins) as water and CO2 transporters [PDF]

, 2008
We identified barley aquaporins and demonstrated that one, HvPIP2;1, transports water and CO2. Regarding water homeostasis in plants, regulations of aquaporin expression were observed in many plants under several environmental stresses. Under salt stress,
Yuko T. Hanba, Katsuhara, Maki, Maki Katsuhara, Hanba, Yuko T.   +3 more
core   +1 more source

Recombinant plasma proteins [PDF]

Vox Sanguinis, 2010
For almost 50 years, the fractionation of human plasma has been the sole possible source of a wide range of therapeutic proteins–such as coagulation factors, anticoagulants, immunoglobulins, and albumin – essential to the treatment of serious congenital or acquired bleeding or immunological diseases. In the last 20 years, the application of recombinant
openaire   +2 more sources

Molecular and serologic analysis of linked blood donor and recipient samples to rule out transfusion-transmitted parvovirus B19 infection

Frontiers in Public Health
IntroductionParvovirus B19 (B19V) has been found in asymptomatic blood donors. This prospective study tested linked blood donor–recipient samples from patients transfused at the National Institutes of Health (NIH) and affiliated hospitals for the ...
Maureen J. Miller, Maria Luisa Virata, Hailing Yan, Lilin Zhong, Sreya Tarafdar, Sarah Fowler, Pei Zhang, Harvey J. Alter, Valeria De Giorgi   +8 more
doaj   +1 more source

Comparative proteomic analysis of plasma proteins in patients with age-related macular degeneration [PDF]

International Journal of Ophthalmology, 2014
AIM: To find the significant altered proteins in age-related macular degeneration (AMD) patients as potential biomarkers of AMD.METHODS: A comparative analysis of the protein pattern of AMD patients versus healthy controls was performed by means of ...
Xin-Rong Xu, Lu Zhong, Bing-Lin Huang, Yuan-Hua Wei, Xin Zhou, Ling Wang, Fu-Qiang Wang   +6 more
doaj   +1 more source

Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections. [PDF]

, 2010
Despite significant research efforts aimed at understanding the neurobiological underpinnings of psychiatric disorders, the diagnosis and the evaluation of treatment of these disorders are still based solely on relatively subjective assessment of ...
Brittain, Claire, Holsboer, Florian, Inga Prokopenko, Robert C Alexander, Rujescu, D., Enrico Domenici, Bullmore, E., Giegling, Ina, Tozzi, F., Claire Brittain, Prokopenko, I, Turck, C., Ina Giegling, Merlo-Pich, E, Middleton, Lefkos, Wille, DR, Tozzi, Federica, Domenici, Enrico, Merlo-Pich, Emilio, Willé, David R., Miller, Sam, Astrid McKeown, Domenici, E, Edward T Bullmore, Middleton, L, Bullmore, ET, Alexander, Robert C., Tozzi, F, Robert C. Alexander, Holsboer, F, Emilio Merlo-Pich, Merlo-Pich, E., Rujescu, D, Sam Miller, McKeown, A, Middleton, L., Christoph W Turck, Federica Tozzi, Enrico Domenici, Prokopenko, I., Wille, D., David R Willé, Pierandrea Muglia, Giegling, I, McKeown, A., Turck, CW, Holsboer, F., Dan Rujescu, Bullmore, Edward T., Brittain, C, Christoph W. Turck, McKeown, Astrid, Muglia, P, Alexander, RC, Prokopenko, Inga, Miller, S., Giegling, I., Alexander, R., Muglia, P., David R. Willé, Edward T. Bullmore, Muglia, Pierandrea, Florian Holsboer, Brittain, C., Miller, S, Lefkos Middleton, Domenici, E., Turck, Christoph W., Rujescu, Dan, Rujescu Dan, Tozzi Federica, Holsboer Florian, Middleton Lefkos, Prokopenko Inga, McKeown Astrid, Domenici Enrico, Muglia Pierandrea, Bullmore Edward T., Giegling Ina, Merlo-Pich Emilio, Turck Christoph W., Alexander Robert C., Brittain Claire, Miller Sam, Willé David R.   +84 more
core   +1 more source