Results 21 to 30 of about 1,013,457 (265)

Stiffness-Induced Endothelial DLC-1 Expression Forces Leukocyte Spreading through Stabilization of the ICAM-1 Adhesome

Cell Reports, 2018
Summary: Leukocytes follow the well-defined steps of rolling, spreading, and crawling prior to diapedesis through endothelial cells (ECs). We found increased expression of DLC-1 in stiffness-associated diseases like atherosclerosis and pulmonary arterial
Lilian Schimmel, Miesje van der Stoel, Carmela Rianna, Anne-Marieke van Stalborch, Aafke de Ligt, Mark Hoogenboezem, Simon Tol, Jos van Rijssel, Robert Szulcek, Harm Jan Bogaard, Patrick Hofmann, Reinier Boon, Manfred Radmacher, Vivian de Waard, Stephan Huveneers, Jaap D. van Buul   +15 more
doaj   +1 more source

Molecular and serologic analysis of linked blood donor and recipient samples to rule out transfusion-transmitted parvovirus B19 infection

Frontiers in Public Health
IntroductionParvovirus B19 (B19V) has been found in asymptomatic blood donors. This prospective study tested linked blood donor–recipient samples from patients transfused at the National Institutes of Health (NIH) and affiliated hospitals for the ...
Maureen J. Miller, Maria Luisa Virata, Hailing Yan, Lilin Zhong, Sreya Tarafdar, Sarah Fowler, Pei Zhang, Harvey J. Alter, Valeria De Giorgi   +8 more
doaj   +1 more source

Comparative proteomic analysis of plasma proteins in patients with age-related macular degeneration [PDF]

International Journal of Ophthalmology, 2014
AIM: To find the significant altered proteins in age-related macular degeneration (AMD) patients as potential biomarkers of AMD.METHODS: A comparative analysis of the protein pattern of AMD patients versus healthy controls was performed by means of ...
Xin-Rong Xu, Lu Zhong, Bing-Lin Huang, Yuan-Hua Wei, Xin Zhou, Ling Wang, Fu-Qiang Wang   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Analysis of Destruction Process of the Primary Thrombus Under the Influence of the Blood Flow

Journal of Biomechanical Science and Engineering, 2007
Stokesian dynamics method based on the approximation of the additivity of velocities was employed to analyze the mechanical behavior of the primary thrombus under the blood flow.
Koichiro YANO, Daisuke MORI, Ken-ichi TSUBOTA, Takuji ISHIKAWA, Shigeo WADA, Takami YAMAGUCHI   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Proteomic Exploration of Plasma Exosomes and Other Small Extracellular Vesicles in Pediatric Hodgkin Lymphoma: A Potential Source of Biomarkers for Relapse Occurrence

Diagnostics, 2021
Exosomes and other small extracellular vesicles (EVs) are potential sources of cancer biomarkers. Plasma-derived EVs have not yet been studied in pediatric Hodgkin lymphoma (HL), for which predictive biomarkers of relapse are greatly needed.
Ombretta Repetto, Federica Lovisa, Caterina Elia, Daniel Enderle, Filippo Romanato, Salvatore Buffardi, Alessandra Sala, Marta Pillon, Agostino Steffan, Roberta Burnelli, Lara Mussolin, Maurizio Mascarin, Valli De Re   +12 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Plasma Protein. IV. Results with Generally Labeled Plasma Protein.

Experimental Biology and Medicine, 1952
SummaryIt is possible to produce generally labeled plasma protein with very high specific activity in rats by feeding them suitable bacteria (Rhodospirillum rubrum) cultured in media containing labeled bicarbonate. These bacteria have protein in which all the amino acids present are labeled.
I A, ABDOU, H, TARVER
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source