Results 21 to 30 of about 3,835,960 (298)

Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ

Haematologica, 2018
Formation of microthrombi is a hallmark of acquired thrombotic thrombocytopenic purpura. These microthrombi originate from insufficient processing of ultra large von Willebrand factor multimers by ADAMTS13 due to the development of anti-ADAMTS13 ...
Johana Hrdinová, Fabian C. Verbij, Paul H.P. Kaijen, Robin B. Hartholt, Floris van Alphen, Neubury Lardy, Anja ten Brinke, Karen Vanhoorelbeke, Pooja J. Hindocha, Anne S. De Groot, Alexander B. Meijer, Jan Voorberg, Ivan Peyron   +12 more
doaj   +1 more source

Label-free Analysis of CD8+ T Cell Subset Proteomes Supports a Progressive Differentiation Model of Human-Virus-Specific T Cells

Cell Reports, 2017
Summary: Pathogens trigger T cells to express distinct sets of effector proteins. To better understand the molecular mechanisms that drive functional specification, we used high-resolution mass spectrometry and label-free protein quantification to ...
Michiel C. van Aalderen, Maartje van den Biggelaar, Ester B.M. Remmerswaal, Floris P.J. van Alphen, Alexander B. Meijer, Ineke J.M. ten Berge, René A.W. van Lier   +6 more
doaj   +1 more source

Deiminated Proteins in Extracellular Vesicles and Plasma of Nurse Shark (Ginglymostoma cirratum) - Novel Insights into Shark Immunity [PDF]

, 2019
Peptidylarginine deiminases (PADs) are phylogenetically conserved calcium-dependent enzymes which post-translationally convert arginine into citrulline in target proteins in an irreversible manner, causing functional and structural changes in target ...
Lange, S., Kraev, Igor, Criscitiello, M.F., Criscitiello, Michael F., Lange, Sigrun, Kraev, I.   +5 more
core   +1 more source

A subset of anti-HLA antibodies induces FcγRIIa-dependent platelet activation

Haematologica, 2018
HLA antibodies are associated with refractoriness to platelet transfusion, leading to rapid platelet clearance, sometimes coinciding with clinical side effects such as fever and chills.
Maaike Rijkers, Anno Saris, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Ruben Bierings, Frank W.G. Leebeek, A.J. Gerard Jansen, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +11 more
doaj   +1 more source

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins [PDF]

, 2013
Signaling through G proteins normally involves conformational switching between GTP- and GDP-bound states. Several Rho GTPases are also regulated by RhoGDI binding and sequestering in the cytosol.
Riou, P, Parker, Peter J., O’Reilly, N., George, Roger, Ritu Garg, McColl, Brad, Ganka Bineva, Kjær, S., Svend Kjær, Garg, R, Bineva, G., Thompson, AJ, Reymond, N, Thompson, Andrew J., Philippe Riou, Purkiss, Andrew, Nicola O’Reilly, Parker, Peter J, Brad McColl, Peter J. Parker, Neil Q. McDonald, Parker, Peter J.; id_orcid, O’Reilly, Nicola, Riou, P., Purkiss, A, Parker, PJ, Thompson, A.J., McColl, B, Cain, RJ, Parker, P.J., Kjær, Svend, McColl, B., Andrew Purkiss, O’Reilly, N, Kjær, S, Garg, R., Garg, Ritu, O'Reilly, Nicola, Anne J. Ridley, Cain, Robert J, Robert J. Cain, McDonald, Neil Q, Ridley, Anne J, Bineva, G, Ridley, A.J., Purkiss, Andrew G., Nicolas Reymond, George, R., Thompson, Andrew J, Reymond, N., Reymond, Nicolas, Cain, Robert J., Bineva, Ganka, McDonald, NQ, Riou, Philippe, Andrew J. Thompson, Ridley, AJ, Kjaer, Svend, George, R, Cain, R.J., Ridley, Anne J., Roger George, McDonald, Neil Q.   +62 more
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Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers

Haematologica, 2018
Although outstanding progress has been made in understanding the pathophysiology of thrombotic thrombocytopenic purpura (TTP), knowledge of the immunopathogenesis of the disease is only at an early stage. Anti-ADAMTS13 auto-antibodies were shown to block
Johana Hrdinová, Silvia D’Angelo, Nuno A. G. Graça, Bogac Ercig, Karen Vanhoorelbeke, Agnès Veyradier, Jan Voorberg, Paul Coppo   +7 more
doaj   +1 more source

Counting the Proteins in Plasma [PDF]

Clinical Chemistry, 2010
Featured Article: Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, et al. The human plasma proteome: a non-redundant list developed by combination of four separate sources. Mol Cell Proteomics 2004;3:311–26.2 The problem of enumerating protein components in plasma has challenged the best analytical technologies for more than 80 ...
openaire   +2 more sources

A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin' [PDF]

, 2005
The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin.
Guild, Simon, Lissa R. Herron, Brophy, Peter J, Prystowsky, Michael B., Margaret Brandwein-Gensler, Michael B. Prystowsky, Gavin I. Welsh, Gunn-Moore, Frank J., Venkateswarlu, Kanamarlapudi, Tavaré, Jeremy M, Tavaré, Jeremy M., Gunn-Moore, Francis James, Frank J. Gunn-Moore, Tavaré, JM, Herron, Lissa R, Herron, Lissa R., Gillespie, Stewart, Brannigan, Frances, Prystowsky, M, Stewart Gillespie, Prystowsky, Michael B, Welsh, Gavin I., Frances Brannigan, Tavare, J, Welsh, Gavin I, Welsh, GI, Prystowsky, MB, Kanamarlapudi Venkateswarlu, Brophy, P, Herron, LR, Simon Guild, Brandwein-Gensler, M, Madan, R, Peter J. Brophy, Gunn-Moore, FJ, Gillespie, S, Brophy, Peter J., Rashna Madan, Brannigan, F, Welsh, G, Gunn-Moore, Frank J, Brandwein-Gensler, Margaret, Venkateswarlu, K, Guild, S, Madan, Rashna, Jeremy M. Tavaré, Brophy, PJ, Herron, L, Venkat Kanamarlapudi   +48 more
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Molecular signature of methotrexate response among rheumatoid arthritis patients

Frontiers in Medicine, 2023
BackgroundMethotrexate (MTX) is the first line treatment for rheumatoid arthritis (RA), but failure of satisfying treatment response occurs in a significant proportion of patients.
Boel Brynedal, Boel Brynedal, Niyaz Yoosuf, Niyaz Yoosuf, Niyaz Yoosuf, Tinna Bjorg Ulfarsdottir, Daniel Ziemek, Mateusz Maciejewski, Lasse Folkersen, Helga Westerlind, Helga Westerlind, Malin Müller, Malin Müller, Peter Sahlström, Peter Sahlström, Scott A. Jelinsky, Aase Hensvold, Aase Hensvold, Aase Hensvold, Leonid Padyukov, Leonid Padyukov, Nancy Vivar Pomiano, Nancy Vivar Pomiano, Anca Catrina, Anca Catrina, Lars Klareskog, Lars Klareskog, Louise Berg, Louise Berg   +28 more
doaj   +1 more source

Stiffness-Induced Endothelial DLC-1 Expression Forces Leukocyte Spreading through Stabilization of the ICAM-1 Adhesome

Cell Reports, 2018
Summary: Leukocytes follow the well-defined steps of rolling, spreading, and crawling prior to diapedesis through endothelial cells (ECs). We found increased expression of DLC-1 in stiffness-associated diseases like atherosclerosis and pulmonary arterial
Lilian Schimmel, Miesje van der Stoel, Carmela Rianna, Anne-Marieke van Stalborch, Aafke de Ligt, Mark Hoogenboezem, Simon Tol, Jos van Rijssel, Robert Szulcek, Harm Jan Bogaard, Patrick Hofmann, Reinier Boon, Manfred Radmacher, Vivian de Waard, Stephan Huveneers, Jaap D. van Buul   +15 more
doaj   +1 more source