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Biological Psychiatry, 2021
Genome-wide association studies have identified multiple risk variants for psychiatric disorders. Nevertheless, how the risk variants confer risk of psychiatric disorders remains largely unknown.We performed proteome-wide association studies to identify genes whose cis-regulated protein abundance change in the human brain were associated with ...
Jiewei Liu, Xiaoyan Li, Xiong-Jian Luo
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Genome-wide association studies have identified multiple risk variants for psychiatric disorders. Nevertheless, how the risk variants confer risk of psychiatric disorders remains largely unknown.We performed proteome-wide association studies to identify genes whose cis-regulated protein abundance change in the human brain were associated with ...
Jiewei Liu, Xiaoyan Li, Xiong-Jian Luo
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The American Journal of Human Genetics
We performed a series of integrative analyses including transcriptome-wide association studies (TWASs) and proteome-wide association studies (PWASs) of renal cell carcinoma (RCC) to nominate and prioritize molecular targets for laboratory investigation.
Diptavo Dutta +142 more
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We performed a series of integrative analyses including transcriptome-wide association studies (TWASs) and proteome-wide association studies (PWASs) of renal cell carcinoma (RCC) to nominate and prioritize molecular targets for laboratory investigation.
Diptavo Dutta +142 more
openaire +2 more sources
2023
Abstract Common and rare variants in the LRRK2 locus are associated with Parkinson’s disease (PD) risk, but the downstream effects of these variants on protein levels remains unknown.
Bridget Phillips +25 more
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Abstract Common and rare variants in the LRRK2 locus are associated with Parkinson’s disease (PD) risk, but the downstream effects of these variants on protein levels remains unknown.
Bridget Phillips +25 more
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Proteome-Wide and Transcriptome-Wide Association Studies of Kidney Function
Journal of the American Society of Nephrology, 2021Pascal Schlosser +10 more
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New Etiological Insights of Psychiatric Disorders by Proteome-wide Association Study
Biological Psychiatry, 2021openaire +2 more sources
Cancer Research
Abstract Background: Genome-wide association studies (GWAS) have identified over 200 breast cancer risk associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive. Proteins, as final gene products, are pivotal in cellular function.
Tianying Zhao +10 more
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Abstract Background: Genome-wide association studies (GWAS) have identified over 200 breast cancer risk associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive. Proteins, as final gene products, are pivotal in cellular function.
Tianying Zhao +10 more
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Human Brain Proteome-Wide Association Study Implicates Potential Therapeutic Targets for Obesity
2023Qigang Zhao +7 more
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Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 2023
Jingyuan Xiong, Siquan Zhou
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Jingyuan Xiong, Siquan Zhou
exaly