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Biological Psychiatry, 2021
Genome-wide association studies have identified multiple risk variants for psychiatric disorders. Nevertheless, how the risk variants confer risk of psychiatric disorders remains largely unknown.We performed proteome-wide association studies to identify genes whose cis-regulated protein abundance change in the human brain were associated with ...
Jiewei Liu, Xiaoyan Li, Xiong-Jian Luo
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Genome-wide association studies have identified multiple risk variants for psychiatric disorders. Nevertheless, how the risk variants confer risk of psychiatric disorders remains largely unknown.We performed proteome-wide association studies to identify genes whose cis-regulated protein abundance change in the human brain were associated with ...
Jiewei Liu, Xiaoyan Li, Xiong-Jian Luo
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The American Journal of Human Genetics
We performed a series of integrative analyses including transcriptome-wide association studies (TWASs) and proteome-wide association studies (PWASs) of renal cell carcinoma (RCC) to nominate and prioritize molecular targets for laboratory investigation.
Diptavo Dutta +142 more
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We performed a series of integrative analyses including transcriptome-wide association studies (TWASs) and proteome-wide association studies (PWASs) of renal cell carcinoma (RCC) to nominate and prioritize molecular targets for laboratory investigation.
Diptavo Dutta +142 more
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2022
AbstractProteome-wide association study (PWAS) integrating proteomics data with GWAS data is a powerful tool to identify risk genes for complex diseases, which can inform disease mechanisms with genetic effects mediated through protein abundance. We propose a novel omnibus method to improve PWAS power by modeling unknown genetic architectures with ...
Tingyang Hu +8 more
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AbstractProteome-wide association study (PWAS) integrating proteomics data with GWAS data is a powerful tool to identify risk genes for complex diseases, which can inform disease mechanisms with genetic effects mediated through protein abundance. We propose a novel omnibus method to improve PWAS power by modeling unknown genetic architectures with ...
Tingyang Hu +8 more
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2023
AbstractCommon and rare variants in theLRRK2locus are associated with Parkinson’s disease (PD) risk, but the downstream effects of these variants on protein levels remains unknown. We performed comprehensive proteogenomic analyses using the largest aptamer-based CSF proteomics study to date (7,006 aptamers (6,138 unique proteins) in 3,107 individuals).
Bridget Phillips +25 more
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AbstractCommon and rare variants in theLRRK2locus are associated with Parkinson’s disease (PD) risk, but the downstream effects of these variants on protein levels remains unknown. We performed comprehensive proteogenomic analyses using the largest aptamer-based CSF proteomics study to date (7,006 aptamers (6,138 unique proteins) in 3,107 individuals).
Bridget Phillips +25 more
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Cancer Research
Abstract Background: Genome-wide association studies (GWAS) have identified over 200 breast cancer risk associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive. Proteins, as final gene products, are pivotal in cellular function.
Tianying Zhao +10 more
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Abstract Background: Genome-wide association studies (GWAS) have identified over 200 breast cancer risk associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive. Proteins, as final gene products, are pivotal in cellular function.
Tianying Zhao +10 more
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Proteome-Wide and Transcriptome-Wide Association Studies of Kidney Function
Journal of the American Society of Nephrology, 2021Pascal Schlosser +10 more
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