Results 231 to 240 of about 114,169 (274)

Bioresponsive pseudoGlucosinolates (psGSLs) Release Isothiocyanates (ITCs) in the Presence of Nitroreductases

Chemistry – A European Journal, EarlyView.
This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase‐responsive psGSLs. These compounds represent a complementary prodrug strategy to natural glucosinolates (GSLs) for the controlled release of isothiocyanates (ITCs), enabling bio‐responsive protein labeling, as demonstrated in ...
Claire C. Jimidar, Charity S. G. Ganskow, Mervic D. Kagho, Aishi Chakrabarti, Lorenz Wiese, Michael Zollo, Ulrike Beutling, Leona C. Cesar, Julia Morud, Kamila Bugaj, Mark Brönstrup, Stephan A. Sieber, Stephan M. Hacker, Philipp Klahn   +13 more
wiley   +1 more source

Cross-trait genomic modeling reveals the polygenic architecture and systemic impact of MASLD. [PDF]

Sci Adv
Du M, Yuan H, Wu T, Jiang Y, Suo C, Jin L, Zhang T, Liu Z, Chen X.   +8 more
europepmc   +1 more source

Tetrazine Ligation in Living Systems: Beyond Fast Kinetics to Effective Bioorthogonality

Chemistry – A European Journal, EarlyView.
Rapid reaction kinetics (k2) alone do not ensure successful tetrazine ligation in living systems. This review introduces ‘effective orthogonality’—focusing on chemical survival, availability, and encounter—as a practical framework. We highlight how bottlenecks shift from cellular sinks to in vivo delivery limits, offering design strategies for reliable
Junhyeong Yim, Junyoung Park, Youngjun Lee, Jongmin Park   +3 more
wiley   +1 more source

Unveiling Hepatic Protein Alterations in Neonatal and Infant Biliary Atresia

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric populations differ from adults in drug elimination capacity. While current scaling methods account for enzyme and transporter maturation, they overlook comorbidities, such as biliary atresia (BA), a liver disease appearing within the first 2–8 weeks of life that can progress to cirrhosis.
Zubida M. Al‐Majdoub, Martyn Howard, Brahim Achour, Jill Barber, Naved Alizai, Amin Rostami‐Hodjegan   +5 more
wiley   +1 more source

GlycA as an Effect Modifier of Protein-Mortality Associations: A Prospective Cohort Study. [PDF]

Clin Transl Sci
Wang X, Qiao Z, Tao C, Liao S, Li Z, Xu Q, Fan Y, Wang Y, Han Y, Dai X, Lu C.   +10 more
europepmc   +1 more source

A Multiomic Approach Integrating Genomic and Metabolomic Data Highlights Colorectal Cancer Pathways. [PDF]

J Proteome Res
Iliou A, Chekmeneva E, Pinto RC, Koukouzeli FE, Ntounias Y, Georgakopoulou K, Pouliou M, Agelopoulos M, Tsilidis KK, Gunter MJ, Elliott P, Griffin JL, Dehghan A, Klinakis A, Mikros E, Tzoulaki I.   +15 more
europepmc   +1 more source

Large-Scaled Proteomics Analysis for Glaucoma: Integrated Genetics, Multi-Omics, UK Biobank and Therapeutic Analysis. [PDF]

Invest Ophthalmol Vis Sci
Xu J, Gao Y, Yu J, Xu Z, Zhang Y, Pang CP, Tham CC, Yam JC, Chen LJ.   +8 more
europepmc   +1 more source

Assessing the causal relationship between the plasma proteome and epilepsy: A Mendelian randomization study. [PDF]

Epilepsia Open
Fu J, Wu W, Shen S.
europepmc   +1 more source

Proteome-wide Mendelian randomization identifies drug targets for atrial fibrillation/flutter. [PDF]

BMC Cardiovasc Disord
Jia Q, Yang Y, Chen X, Hu Z.
europepmc   +1 more source