Results 231 to 240 of about 41,903,721 (265)

Integrative genomic and proteomic analyses identify candidate genetic loci and genetically supported proteins in age-related macular degeneration. [PDF]

Eye Vis (Lond)
Chen N, Liu Y, Chen Z, Xiang Y, Yu H.
europepmc   +1 more source

Reln mRNA Delivery Drives Neurogenic Bone Regeneration by Orchestrating Schwann Cell‐Mediated Exosomal Trafficking

Advanced Science, EarlyView.
MSNs serve as a robust vehicle for CRISPRa‐mediated Reln induction, driving bone repair through the establishment of a neurogenic‐supportive microenvironment. ABSTRACT Neurogenic bone regeneration is essential for the effective restoration of bone tissue functionality, while the mechanisms and new strategies underlying neurogenic bone regeneration ...
Shuai Lin, Qianwen Li, Duo Liu, Mingzhao Li, Han Zhang, Liujing Chen, Yan Yu, Jiuhui Jiang, Chun Xu, Ruili Yang   +9 more
wiley   +1 more source

Cataract genetics: bringing disease modification into focus. [PDF]

EBioMedicine
Mi Y, Hong Y, Wan M.
europepmc   +1 more source

Proteome-Wide Profiling of Lysine 2-Hydroxyisobutyrylation in <i>Vibrio alginolyticus</i> and Preliminary Association of CobQ with Global Khib Levels. [PDF]

Life (Basel)
Wen X, Yang S, Liang Y, Zhang Y, Wei Y, Zhang W, Jian J, Wang N, Pang B, Pang H.   +9 more
europepmc   +1 more source

Paediatric proteomic signatures of cardiometabolic disease-associated traits predict adult disease outcomes. [PDF]

Nat Metab
Landman JM, Highland HM, Perry AS, Howard AG, Sheng Q, Lorenz A, Palmer AB, Zhao S, Zhu W, Zhang X, Buchanan VL, Frankel EG, Roshani R, Scartozzi A, Farber-Eger EH, Anwar MY, Sprinkles JK, Breidenbach A, Wang TC, Ballard CA, Nayor M, Tamaroff J, Gutierrez A, Petty LE, Petty AS, Lippi B, Fernandez-Rhodes L, Chen HH, Krishnan M, Graff M, Meyer KA, Lee M, Young KL, Wells Q, Tanriverdi K, Freedman JE, Gamazon ER, McCormick JB, Fisher-Hoch SP, Gordon-Larsen P, Below JE, North KE, Shah RV.   +42 more
europepmc   +1 more source

Integrating Proteome-Wide Association Studies and Single-Cell Transcriptomics Identifies GSTT2B as a Causal Mediator and Prioritizes COL4A1 in Diabetic Retinopathy. [PDF]

Int J Mol Sci
Wen L, Liu Y, Zhang K, Mao A, Geng L, Yu F, Feng L, Kan H.   +7 more
europepmc   +1 more source

Beyond the classical plasma secretome: genetic architecture and disease associations of the expanded human plasma proteome in 13,445 Europeans

Cadiou S, König E, Mapelli A, Pontali G, Ghasemi-Semeskandeh D, Filosi M, Ferolito BR, Massi MC, Cuccuru G, Jiang X, Winicki G, Navarro-Gallinad A, Gravel-Pucillo K, Pirastu N, Landini A, Sharapov S, Rainer J, Gögele M, Lundin R, Mascalzoni D, Biasiotto R, Blankenburg H, De Grandi A, Egger C, Arend L, Woller F, Ieva F, Soranzo N, Cho K, Gaziano JM, Zuccolo L, Domingues FS, Pattaro C, Danesh J, Pramstaller PP, Pereira A, Angelantonio ED, Fuchsberger C, Giambartolomei C, Butterworth AS.   +39 more
europepmc   +1 more source

The Genetic Structure of Pain in Depression Patients: A Genome-Wide Association Study and Proteome-Wide Association Study [PDF]

Journal of Psychiatric Research, 2022
Comparing with the general population, the pain in depression patients has more complex biological mechanism. We aim to explore the etiological mechanism of pain in depression patients from the perspective of genetics.Utilizing the UK Biobank samples with self-reported depression status or PHQ score ≥10, we conducted genome-wide association studies ...
Zhen Zhang, Yujing Chen
exaly   +4 more sources

Integrated Analysis of Proteome-Wide and Transcriptome-Wide Association Studies Identified Novel Genes and Chemicals for Vertigo.

Brain Communications, 2022
Abstract Vertigo is a leading symptom of various peripheral and central vestibular disorders. Although genome-wide association studies (GWASs) have identified multiple risk variants for vertigo, how these risk variants contribute to the risk of vertigo remains unknown.
Peilin Meng, Shiqiang Cheng, Yumeng Jia
exaly   +3 more sources