Genome Biology, 2020 We introduce Proteome-Wide Association Study (PWAS), a new method for detecting gene-phenotype associations mediated by protein function alterations. PWAS aggregates the signal of all variants jointly affecting a protein-coding gene and assesses their ...
Nadav Brandes +2 more
exaly +3 more sources
Linear and non-linear proteome-wide association studies provide novel insight into venous thromboembolism [PDF]
Nature CommunicationsVenous thromboembolism is a life-threatening vascular event with high prevalence and genetic determinants. PWAS has become a popular strategy to identify therapeutic targets of complex diseases.
Yifan Kong +9 more
doaj +2 more sources
Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer’s disease dementia [PDF]
Alzheimer’s Research & TherapyBackground A proteome-wide association study (PWAS) that integrates proteomic data with genome-wide association study (GWAS) summary data is a powerful tool for studying Alzheimer’s disease (AD) dementia.
Tingyang Hu +10 more
doaj +2 more sources
Exploring Language Recovery Pattern in Persons with Aphasia Across Acute and Sub-Acute Stages [PDF]
Behavioral SciencesRecovery from aphasia is a complex process involving restoring language ability to a level comparable to an individual’s pre-aphasia state. This recovery extends beyond linguistic functions such as improved quality of life and functional communication ...
Deepak Puttanna +4 more
doaj +2 more sources
Identification and validation of novel risk genes for intervertebral disc disorder by integrating large-scale multi-omics analyses and experimental studies [PDF]
Frontiers in MedicineIntroductionAlthough genome-wide association studies (GWAS) have identified multiple genetic loci linked to intervertebral disc disorder (IDD), their functional characterization remains largely unelucidated.
Zhe Zhang +9 more
doaj +2 more sources
Potential drug targets for chronic obstructive pulmonary disease in the plasma proteome identified through Mendelian randomization [PDF]
BMC Pulmonary MedicineBackground Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Current options such as glucocorticoids and bronchodilators improve symptoms but carry risks, including infection and immunosuppression. To guide safer,
Qinyao Jia +6 more
doaj +2 more sources
Identification of novel proteins associated with intelligence by integrating genome-wide association data and human brain proteomics. [PDF]
PLoS ONEWhile genome-wide association studies (GWAS) have identified genetic variants associated with intelligence, their biological mechanisms remain largely unexplored.
Zheng Zhang +4 more
doaj +2 more sources
Integrative genomic analysis identifies novel causal genes of Hodgkin’s and non-Hodgkin’s lymphoma [PDF]
Discover OncologyBackground The genetic mechanisms underlying non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) remain understudied. While numerous genes associated with these lymphoid tumors have been identified, little research has focused on the genetic networks ...
Patrick Shi, Ancha Baranova, Hongbao Cao
doaj +2 more sources
Enhancing nonlinear transcriptome- and proteome-wide association studies via trait imputation with applications to Alzheimer's disease. [PDF]
PLoS GeneticsGenome-wide association studies (GWAS) performed on large cohort and biobank datasets have identified many genetic loci associated with Alzheimer's disease (AD). However, the younger demographic of biobank participants relative to the typical age of late-
Ruoyu He +3 more
doaj +2 more sources
European Psychiatry, 2023 Objective Genetic approaches are increasingly advantageous in characterizing treatment-resistant schizophrenia (TRS). We aimed to identify TRS-associated functional brain proteins, providing a potential pathway for improving psychiatric classification ...
Wenming Wei +13 more
doaj +1 more source