Results 1 to 10 of about 1,830 (221)

PWAS: proteome-wide association study—linking genes and phenotypes by functional variation in proteins

Genome Biology, 2020
We introduce Proteome-Wide Association Study (PWAS), a new method for detecting gene-phenotype associations mediated by protein function alterations. PWAS aggregates the signal of all variants jointly affecting a protein-coding gene and assesses their ...
Nadav Brandes, Nati Linial, Michal Linial   +2 more
exaly   +3 more sources

Cell-type-aware transcriptome-wide association studies identify 91 independent risk genes for Alzheimer’s disease dementia [PDF]

Communications Biology
Most existing transcriptome wide association studies (TWASs) of Alzheimer’s Disease (AD) dementia only use bulk RNA-seq data and a single statistical method.
Qiang Liu, Randy L. Parrish, Shizhen Tang, Shinya Tasaki, David A. Bennett, Nicholas T. Seyfried, Philip L. De Jager, Vilas Menon, Aron S. Buchman, Jingjing Yang   +9 more
doaj   +2 more sources

Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer’s disease dementia [PDF]

Alzheimer’s Research & Therapy
Background A proteome-wide association study (PWAS) that integrates proteomic data with genome-wide association study (GWAS) summary data is a powerful tool for studying Alzheimer’s disease (AD) dementia.
Tingyang Hu, Qiang Liu, Qile Dai, Aron S. Buchman, David A. Bennett, Shinya Tasaki, Yanling Wang, Nicholas T. Seyfried, Philip L. De Jager, Michael P. Epstein, Jingjing Yang   +10 more
doaj   +2 more sources

Linear and non-linear proteome-wide association studies provide novel insight into venous thromboembolism [PDF]

Nature Communications
Venous thromboembolism is a life-threatening vascular event with high prevalence and genetic determinants. PWAS has become a popular strategy to identify therapeutic targets of complex diseases.
Yifan Kong, Wangxia Tang, Haonan Kang, Yunlong Guan, Si Li, Xi Cao, Zhonghe Shao, Yi Jiang, Chaolong Wang, Xingjie Hao   +9 more
doaj   +2 more sources

Exploring Language Recovery Pattern in Persons with Aphasia Across Acute and Sub-Acute Stages [PDF]

Behavioral Sciences
Recovery from aphasia is a complex process involving restoring language ability to a level comparable to an individual’s pre-aphasia state. This recovery extends beyond linguistic functions such as improved quality of life and functional communication ...
Deepak Puttanna, Nova Maria Saji, Mohammed F. ALHarbi, Akshaya Swamy, Darshan Hosaholalu Sarvajna   +4 more
doaj   +2 more sources

Identification and validation of novel risk genes for intervertebral disc disorder by integrating large-scale multi-omics analyses and experimental studies [PDF]

Frontiers in Medicine
IntroductionAlthough genome-wide association studies (GWAS) have identified multiple genetic loci linked to intervertebral disc disorder (IDD), their functional characterization remains largely unelucidated.
Zhe Zhang, Zhe Zhang, Yu Chen, Qianjin Wang, Zheng Li, Bingyang Dai, Bingyang Dai, Cheng Dong, Cheng Dong, Zhengya Zhu   +9 more
doaj   +2 more sources

Identification of novel functional brain proteins for treatment-resistant schizophrenia: Based on a proteome-wide association study

European Psychiatry, 2023
Objective Genetic approaches are increasingly advantageous in characterizing treatment-resistant schizophrenia (TRS). We aimed to identify TRS-associated functional brain proteins, providing a potential pathway for improving psychiatric classification ...
Wenming Wei, Huijie Zhang, Bolun Cheng, Xiaoyue Qin, Dan He, Na Zhang, Yijing Zhao, Qingqing Cai, Sirong Shi, Xiaoge Chu, Yan Wen, Huan Liu, Yumeng Jia, Feng Zhang   +13 more
doaj   +1 more source

Evaluating Progressive Web App Accessibility for People with Disabilities

Network, 2022
App development is a steadily growing industry. Progressive web apps (PWAs) constitute a technology inspired by native and hybrid apps; they use web technologies to create web and mobile apps.
Konstantinos I. Roumeliotis, Nikolaos D. Tselikas   +1 more
doaj   +1 more source

Main Concept, Sequencing, and Story Grammar Analyses of Cinderella Narratives in a Large Sample of Persons with Aphasia

Brain Sciences, 2021
Recently, a multilevel analytic approach called Main Concept, Sequencing, and Story Grammar (MSSG) was presented along with preliminary normative information.
Jessica D. Richardson, Sarah Grace Dalton, Kathryn J. Greenslade, Adam Jacks, Katarina L. Haley, Janet Adams   +5 more
doaj   +1 more source

FGPE+: The Mobile FGPE Environment and the Pareto-Optimized Gamified Programming Exercise Selection Model—An Empirical Evaluation

Computers, 2023
This paper is poised to inform educators, policy makers and software developers about the untapped potential of PWAs in creating engaging, effective, and personalized learning experiences in the field of programming education.
Rytis Maskeliūnas, Robertas Damaševičius, Tomas Blažauskas, Jakub Swacha, Ricardo Queirós, José Carlos Paiva   +5 more
doaj   +1 more source