Results 31 to 40 of about 2,506 (206)

Linear and non-linear proteome-wide association studies provide novel insight into venous thromboembolism

Nature Communications
Venous thromboembolism is a life-threatening vascular event with high prevalence and genetic determinants. PWAS has become a popular strategy to identify therapeutic targets of complex diseases.
Yifan Kong, Wangxia Tang, Haonan Kang, Yunlong Guan, Si Li, Xi Cao, Zhonghe Shao, Yi Jiang, Chaolong Wang, Xingjie Hao   +9 more
doaj   +1 more source

PWAS: Proteome-Wide Association Study [PDF]

, 2019
Abstract Over the last two decades, GWAS (Genome-Wide Association Study) has become a canonical tool for exploratory genetic research, generating countless gene-phenotype associations. Despite its accomplishments, several limitations and drawbacks still hinder its success, including low statistical power and obscurity about the ...
Nadav Brandes, Nathan Linial, Michal Linial   +2 more
openaire   +2 more sources

Safety of Sodium‐Ion Batteries: Evaluation and Perspective from Component Materials to Cells, Modules, and Packs

Advanced Energy Materials, EarlyView.
This review provides a bottom‐up evaluation of sodium‐ion battery safety, linking material degradation mechanisms, cell engineering parameters, and module/pack assembly. It emphasizes that understanding intrinsic material stability and establishing coordinated engineering control across hierarchical levels are vital for preventing degradation coupling ...
Won‐Gwang Lim, Seoa Kim, Erik A. Wu, Darren H. S. Tan, Shawn Peng, Xiaolin Li   +5 more
wiley   +1 more source

Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer’s disease dementia

Alzheimer’s Research & Therapy
Background A proteome-wide association study (PWAS) that integrates proteomic data with genome-wide association study (GWAS) summary data is a powerful tool for studying Alzheimer’s disease (AD) dementia.
Tingyang Hu, Qiang Liu, Qile Dai, Aron S. Buchman, David A. Bennett, Shinya Tasaki, Yanling Wang, Nicholas T. Seyfried, Philip L. De Jager, Michael P. Epstein, Jingjing Yang   +10 more
doaj   +1 more source

Prediction of arguments and adjuncts in aphasia: Effects of event-related and verb-specific knowledge​

Frontiers in Psychology, 2015
Previous research suggests that on-line access to lexically-stored verb argument structures is relatively preserved in some people with aphasia[9] (PWAs), despite their increased difficulty in producing verbs as compared to nouns[2].
Rebecca A Hayes, Michael Walsh Dickey, Michael Walsh Dickey   +2 more
doaj   +1 more source

Revisiting the concept that interictal implies asymptomatic: Pulse wave amplitude drops uncover autonomic responses during generalized paroxysmal fast activities

Epilepsia, EarlyView.
Abstract Objective Interictal electroencephalographic (EEG) activities are generally considered asymptomatic. Pulse wave amplitude drop (PWAD) is a marker of autonomic nervous system (ANS) reactivity linked to cardiovascular risk. Generalized paroxysmal fast activity (GPFA) is a major EEG pattern in different epileptic conditions.
Julie Lévi‐Strauss, Valerio Frazzini, Claude Adam, Isabelle Gourfinkel‐An, Sophie Dupont, Vincent Navarro, Vi‐Huong Nguyen‐Michel   +6 more
wiley   +1 more source

REFLECTIONS ON BURNOUT AND SELF-CARE MANAGEMENT IN SOCIAL WORK

Social Work/Maatskaplike Werk, 2010
Working with people with AIDS (PWAs) invariably requires that caregivers provide optimalcare both to PWAs with serious illness and functional impairment, and to themselves.Although this work is extremely rewarding, the enormity of the stress and strain ...
Rubeena Partab
doaj   +1 more source

Shared Genetic Pathways Linking Oral Diseases to Gastrointestinal Disorders: An Integrative Multi‐Omics Study

iMetaMed, EarlyView.
Shared genetics pathways connect oral diseases and gut disorders. ABSTRACT Oral diseases are highly prevalent and increasingly recognized as contributors to gastrointestinal disorders. Despite clinical observations of oral–gut comorbidity, the underlying genetic architecture and causal mechanisms remain poorly understood.
Rui Zhang, Yuelan Gao, Yuyang Zhao, Wanyang Zhong, Xingxiang Duan, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Albinism in Tanzania: A Ritual Politics of Silence, Fear, and Subservience

Religions
Violence against people with albinism (PWAs) in Tanzania continues nearly two decades after mass media reported the first incidents in the mid-2000s. The violence is linked to organ trafficking for use in “magical rituals” that allegedly help politicians
Francis Semwaza
doaj   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source