Results 31 to 40 of about 1,830 (221)

Identification of novel drug targets through integrative PWAS of brain and plasma proteins with Ulcerative Colitis GWAS. [PDF]

open access: yesPLoS One
Previous genome-wide association studies (GWAS) have identified various risk variants for ulcerative colitis (UC), but there is a lack of evidence showing how these variants contribute to the development of UC.
Liu N   +8 more
europepmc   +2 more sources

Spectral Resting-State EEG (rsEEG) in Chronic Aphasia Is Reliable, Sensitive, and Correlates With Functional Behavior

open access: yesFrontiers in Human Neuroscience, 2021
We investigated spectral resting-state EEG in persons with chronic stroke-induced aphasia to determine its reliability, sensitivity, and relationship to functional behaviors.
Sarah G. H. Dalton   +2 more
doaj   +1 more source

New insights into the hypothalamic–pituitary– thyroid axis: a transcriptome- and proteome-wide association study

open access: yesEuropean Thyroid Journal
Introduction: Thyroid hormones have systemic effects on the human body and play a key role in the development and function of virtually all tissues.
Sara Monteiro-Martins   +7 more
doaj   +1 more source

PWAS: Proteome-Wide Association Study [PDF]

open access: yes, 2019
Abstract Over the last two decades, GWAS (Genome-Wide Association Study) has become a canonical tool for exploratory genetic research, generating countless gene-phenotype associations. Despite its accomplishments, several limitations and drawbacks still hinder its success, including low statistical power and obscurity about the ...
Nadav Brandes   +2 more
openaire   +1 more source

Safety of Sodium‐Ion Batteries: Evaluation and Perspective from Component Materials to Cells, Modules, and Packs

open access: yesAdvanced Energy Materials, EarlyView.
This review provides a bottom‐up evaluation of sodium‐ion battery safety, linking material degradation mechanisms, cell engineering parameters, and module/pack assembly. It emphasizes that understanding intrinsic material stability and establishing coordinated engineering control across hierarchical levels are vital for preventing degradation coupling ...
Won‐Gwang Lim   +5 more
wiley   +1 more source

Prediction of arguments and adjuncts in aphasia: Effects of event-related and verb-specific knowledge​

open access: yesFrontiers in Psychology, 2015
Previous research suggests that on-line access to lexically-stored verb argument structures is relatively preserved in some people with aphasia[9] (PWAs), despite their increased difficulty in producing verbs as compared to nouns[2].
Rebecca A Hayes   +2 more
doaj   +1 more source

Beyond Traditional Screening: The Future of Heart Failure Detection With Biomarkers and AI

open access: yesiNew Medicine, EarlyView.
Advancing HF Screening: Integrating Technology and Risk Factors Across Eras. This diagram provides a comprehensive review of the historical developments and projected trends of heart failure (HF) screening methodologies, with the prevalent risk factors for HF depicted at the base.
Xiaofeng Fang   +9 more
wiley   +1 more source

REFLECTIONS ON BURNOUT AND SELF-CARE MANAGEMENT IN SOCIAL WORK

open access: yesSocial Work/Maatskaplike Werk, 2010
Working with people with AIDS (PWAs) invariably requires that caregivers provide optimalcare both to PWAs with serious illness and functional impairment, and to themselves.Although this work is extremely rewarding, the enormity of the stress and strain ...
Rubeena Partab
doaj   +1 more source

Impact of Heated Versus Unheated Cooking Oil on Postprandial Vascular Function and Metabolism

open access: yesLipids, EarlyView.
ABSTRACT The impact of repeated heating of seed‐based culinary oils on cardiometabolic health has not been well established. Heating oils to high temperatures (> 150°C) causes lipid peroxidation, thus generating potentially harmful compounds that may impair vascular function. This randomized, single‐blind, crossover study investigated the acute effects
Rosiered Brownson‐Smith   +5 more
wiley   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou   +4 more
wiley   +1 more source

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