Results 221 to 230 of about 461,354 (348)

π‐PhenoDrug: A Comprehensive Deep Learning‐Based Pipeline for Phenotypic Drug Screening in High‐Content Analysis

Advanced Intelligent Systems, EarlyView.
This study develops a deep learning‐based pipeline named π‐PhenoDrug for cell phenotype‐driven drug activity screening. π‐PhenoDrug integrates cell segmentation, morphological profile construction, and phenotype analysis modules, and it can assess drug effects on living cells in both supervised and unsupervised modes.
Xiao Li, Qinxue Ouyang, Mingfei Han, Xiaoqing Liu, Fuchu He, Yunping Zhu, Ling Leng, Jie Ma   +7 more
wiley   +1 more source

Among-population proteomic differences in Schistocephalus solidus based on excretory/secretory and total body protein predictions. [PDF]

Parasit Vectors
Wang A, Bolnick DI.
europepmc   +1 more source

Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers

Advanced NanoBiomed Research, EarlyView.
Lanthanide‐based luminescence nanothermometry holds multifaceted potential for nanomedical applications, yet despite significant research advances, clinical translation of the engineered nanomaterials is still controversial and widely disputed. This is related to crucial nanotoxicological aspects that must be addressed at the preclinical level ...
Simona Premcheska, Andre G. Skirtach, Anna M. Kaczmarek   +2 more
wiley   +1 more source

Proteomic surveys of the mouse heart unveil cardiovascular responses to nitric oxide/cGMP signaling deficiencies. [PDF]

Commun Biol
Mohanty I, Fazelinia H, Raimo S, Ding H, Spruce L, Symeonidou M, Tenopoulou M, Ichinose F, Yamashita H, Shimokawa H, Masato T, Doulias PT, Ischiropoulos H.   +12 more
europepmc   +1 more source

Extracellular Vesicles in Calcium Oxalate Nephrolithiasis: Emerging Biomarkers and Therapeutic Potential

Advanced NanoBiomed Research, EarlyView.
Kidney stones cause significant pain and healthcare costs. Current prediction, diagnosis, and treatment options are limited. Extracellular vesicles (EVs), rich in proteins, lipids, and nucleic acids, offer a promising solution. This review explores the roles of EVs in kidney stone management, highlighting their potential as biomarkers and therapeutic ...
Wang Zhu, Xu Changzhi, Deng Qiong, Liang Hui   +3 more
wiley   +1 more source

Precision Medicine and the Human Proteome in Disease, Diagnostics and Translation: Current Status and Future Prospects. [PDF]

Biomedicines
Qoronfleh MW.
europepmc   +1 more source

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

Advanced NanoBiomed Research, EarlyView.
Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo, Yen‐Tzu Liao, Hsinyu Lee   +2 more
wiley   +1 more source

In-Depth Cell-Type-Specific Proteome Landscape of the Brain from Human Amyloid-β Overexpression Mouse Model. [PDF]

Adv Sci (Weinh)
Ryu T, Kim SY, Thuraisamy T, Shin J, Jang Y, Kam TI, Na CH.   +6 more
europepmc   +1 more source

A Comprehensive Proteome of Human Corneal Epithelial Cells Constructed by Cross-platform DIA-Mass Spectrometry. [PDF]

Sci Data
Chan KK, Cheung JK, Chung SR, Kong HK, Bian J, Zhou L, Do CW, Lam TC.   +7 more
europepmc   +1 more source

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

Cell, 2016
Saumya Jain, Joshua R. Wheeler, R. Walters, A. Agrawal, A. Barsic, R. Parker   +5 more
semanticscholar   +1 more source