Results 221 to 230 of about 434,853 (281)

ASH2L‐K312‐Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma

Advanced Science, EarlyView.
In this study, ASH2L‐K312‐lac is identified as a critical driver that promotes the malignant progression of hepatocellular carcinoma (HCC). Furthermore, through a comprehensive series of cell biological and molecular biological experiments, integrated with diverse animal models and systematic application of high‐throughput sequencing technologies, it ...
Hexu Han, Shuai Wang, Lixing Ma, Haimeng Yin, Xinxiang Cheng, YiFan Wang, Suqin Xia, Yi Zhang, Yue Zhang, Rong Zhu, Cuixia Liu, Dakun Zhao, Xiangqian Gu, He Zhu, Yin Yuan   +14 more
wiley   +1 more source

Proteomic surveys of the mouse heart unveil cardiovascular responses to nitric oxide/cGMP signaling deficiencies. [PDF]

Commun Biol
Mohanty I, Fazelinia H, Raimo S, Ding H, Spruce L, Symeonidou M, Tenopoulou M, Ichinose F, Yamashita H, Shimokawa H, Masato T, Doulias PT, Ischiropoulos H.   +12 more
europepmc   +1 more source

Artificial Intelligence‐Driven Proteomics Identifies Plasma Protein Signatures for Diagnosis and Stratification of Behçet's Disease

Advanced Science, EarlyView.
Molecular and functional landscape of BD progression and severity based on in‐depth proteomics. Tree boosting machine learning models with favorable performance in BD diagnosis and stratification. Efficient biomarker panels for BD diagnosis and stratification. .
Linlin Cheng, Mansheng Li, Zhou Bai, Xiaobo Yu, Wenjie Zheng, Yongzhe Li, Yudong Liu   +6 more
wiley   +1 more source

Sequential Fractionation and Two-dimensional Gel Analysis Unravels the Complexity of the Dimorphic Fungus Candida albicans Cell Wall Proteome [PDF]

, 2002
Aída Pitarch, Miguel Sánchez, César Nombela, Concha Gil   +3 more
openalex   +1 more source

Investigation of Proteome-Tetrazine Reactivity for a Highly Selective Tetrazine Ligation in Live Cells. [PDF]

ACS Cent Sci
Park J, Hahm J, Yim J, Lee H, Hwang HM, Lee S, Park JY, Velladurai A, Gangasani JK, Cho H, Park H, Lee M, Lee J, Eom H, Song WJ, Lee S, Kim E, Park J.   +17 more
europepmc   +1 more source

Utilizing Data Imbalance to Enhance Compound–Protein Interaction Prediction Models

Advanced Intelligent Systems, EarlyView.
This research paper introduces FilmCPI, a sequence‐based model for predicting compound–protein interactions. It uniquely leverages data imbalance between proteins and compounds to improve performance. FilmCPI outperforms baseline models across multiple datasets and demonstrates strong transferability to unseen protein families without increasing ...
Wei Lin, Chi Chung Alan Fung
wiley   +1 more source

Precision Medicine and the Human Proteome in Disease, Diagnostics and Translation: Current Status and Future Prospects. [PDF]

Biomedicines
Qoronfleh MW.
europepmc   +1 more source

Long noncoding RNA GCH1 mediates mitophagy via the PTEN‐induced kinase 1/Parkin pathway to drive chondrocyte dysfunction and cartilage degeneration in osteoarthritis

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract illustrates the role of lncRNA‐GCH1 in regulating mitophagy and its downstream effects on chondrocyte dysfunction and cartilage degradation in osteoarthritis (OA). Elevated lncRNA‐GCH1 stabilizes PINK1 protein, enhancing mitophagy and mitochondrial turnover.
Gang Zeng, Yujun Sun, Taihe Liu, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Weidong Song, Yue Ding   +8 more
wiley   +1 more source

Protein landscape of the brush border membrane of first instar larvae of Frankliniella occidentalis, the western flower thrips. [PDF]

PLoS One
Maurastoni M, Rotenberg D, Mishra R, Bonning BC, Whitfield AE.   +4 more
europepmc   +1 more source

The FindMNDBiomarker Program: Protein Changes in Motor Neuron Disease/Amyotrophic Lateral Sclerosis Postmortem Tissue and Biofluids

Annals of Neurology, EarlyView.
Objective Biomarkers of disease pathogenesis are critically needed for amyotrophic lateral sclerosis (ALS) to facilitate diagnosis and patient stratification into appropriate therapeutic trials. Proteomic studies offer significant potential to advance this, but reproducibility across laboratories is a key component toward identifying protein changes ...
Gabrielle L. Adler, Matthew C. Kiernan, Rachel H. Tan   +2 more
wiley   +1 more source