Results 61 to 70 of about 267,519 (299)

Toll-like receptor 5-mediated signaling enhances liver regeneration in mice

Military Medical Research, 2021
Background Toll-like receptor 5 (TLR5)-mediated pathways play critical roles in regulating the hepatic immune response and show hepatoprotective effects in mouse models of hepatic diseases.
Wen Zhang, Lei Wang, Xue-Hua Sun, Xian Liu, Yang Xiao, Jie Zhang, Ting Wang, Hui Chen, Yi-Qun Zhan, Miao Yu, Chang-Hui Ge, Chang-Yan Li, Guang-Ming Ren, Rong-Hua Yin, Xiao-Ming Yang   +14 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Functional mapping of the zebrafish early embryo proteome and transcriptome

, 2014
Zebrafish is a popular system for studying vertebrate development and disease that shows high genetic conservation with humans. Molecular level studies at different stages of development are essential for understanding the processes deployed during ...
Carney, Tom J., Alli Shaik, Asfa, Li, Zhen, Wee, Sheena, Li, Rachel Hai Xia, Mathavan, Sinnakaruppan, Gunaratne, Jayantha   +6 more
core   +1 more source

Pancreatic cancer cells spectral library by DIA-MS and the phenotype analysis of gemcitabine sensitivity

Scientific Data, 2022
Measurement(s) protein expression profiling Technology Type(s) Mass ...
Ran Kong, Xiaohong Qian, Wantao Ying
doaj   +1 more source

Identification of functional gene modules by integrating multi-omics data and known molecular interactions

Frontiers in Genetics, 2023
Multi-omics data integration has emerged as a promising approach to identify patient subgroups. However, in terms of grouping genes (or gene products) into co-expression modules, data integration methods suffer from two main drawbacks.
Xiaoqing Chen, Xiaoqing Chen, Mingfei Han, Yingxing Li, Xiao Li, Jiaqi Zhang, Yunping Zhu, Yunping Zhu   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Impact of Phenolic Substrate and Growth Temperature on the Arthrobacter chlorophenolicus Proteome

, 2009
We compared the Arthrobacter chlorophenolicus proteome during growth on 4-chlorophenol, 4-nitrophenol, or phenol at 5 and 28 degrees C, both for the wild-type and a mutant strain with mass spectrometry based proteomics.
Unell, Maria,, Sveriges lantbruksuniversitet., Jansson, Janet,   +2 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

The 2022 Report on the Human Proteome from the HUPO Human Proteome Project

, 2022
International audienceThe 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP) illustrates that protein expression has now been credibly detected (neXtProt PE1 level) for 18,407 (93.2%) of the 19,750 predicted proteins coded in ...
Chen, Yu-Ju, Deutsch, Eric, W, Aebersold, Ruedi,, Omenn, Gilbert S.,, Bandeira, Nuno,, Overall, Christopher M.,, Pineau, Charles,, Liu, Siqi,, Bandeira, Nuno, Weintraub, Susan T.,, Roehrl, Michael, H A, Deutsch, Eric W.,, Cristea, Ileana M.,, Roehrl, Michael H. A.,, Chen, Yu-Ju,, Orchard, Sandra,, Nice, Edouard,, Nice, Edouard, Omenn, Gilbert, S, Liu, Siqi, Packer, Nicolle, H, Moritz, Robert L, Deutsch, Eric W, Omenn, Gilbert S, Lindskog, Cecilia, Weintraub, Susan, T, Overall, Christopher, M, Cristea, Ileana M, Packer, Nicolle H.,, Roehrl, Michael HA, Guo, Tiannan, Aebersold, Ruedi, Moritz, Robert, L, Lindskog, Cecilia,, Roehrl, Michael H A, Lane, Lydie,, Cristea, Ileana, M, Packer, Nicolle H, Overall, Christopher M, Weintraub, Susan T, Orchard, Sandra, Pineau, Charles, Guo, Tiannan,, et al., Lane, Lydie, Moritz, Robert L.,   +45 more
core   +1 more source