Results 71 to 80 of about 429,532 (300)

COVID‐19 diagnostic testing: Technology perspective

Clinical and Translational Medicine, 2020
The corona virus disease 2019 (COVID‐19) is a highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2).
Meng Xu, Dan Wang, Hongye Wang, Xiaomei Zhang, Te Liang, Jiayu Dai, Meng Li, Jiahui Zhang, Kai Zhang, Danke Xu, Xiaobo Yu   +10 more
doaj   +1 more source

Toll-like receptor 5-mediated signaling enhances liver regeneration in mice

Military Medical Research, 2021
Background Toll-like receptor 5 (TLR5)-mediated pathways play critical roles in regulating the hepatic immune response and show hepatoprotective effects in mouse models of hepatic diseases.
Wen Zhang, Lei Wang, Xue-Hua Sun, Xian Liu, Yang Xiao, Jie Zhang, Ting Wang, Hui Chen, Yi-Qun Zhan, Miao Yu, Chang-Hui Ge, Chang-Yan Li, Guang-Ming Ren, Rong-Hua Yin, Xiao-Ming Yang   +14 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Pancreatic cancer cells spectral library by DIA-MS and the phenotype analysis of gemcitabine sensitivity

Scientific Data, 2022
Measurement(s) protein expression profiling Technology Type(s) Mass ...
Ran Kong, Xiaohong Qian, Wantao Ying
doaj   +1 more source

Identification of functional gene modules by integrating multi-omics data and known molecular interactions

Frontiers in Genetics, 2023
Multi-omics data integration has emerged as a promising approach to identify patient subgroups. However, in terms of grouping genes (or gene products) into co-expression modules, data integration methods suffer from two main drawbacks.
Xiaoqing Chen, Xiaoqing Chen, Mingfei Han, Yingxing Li, Xiao Li, Jiaqi Zhang, Yunping Zhu, Yunping Zhu   +7 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-PAINT [PDF]

, 2019
In the brain, the strength of each individual synapse is defined by the complement of proteins present or the "local proteome." Activity-dependent changes in synaptic strength are the result of changes in this local proteome and posttranslational protein
Böger, C., Endesfelder, U., Hafner, A., Heilemann, M., Jungmann, R., Malkusch, S., Schlichthärle, T., Schuman, E., Strauss, M.   +8 more
core   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Current challenges in software solutions for mass spectrometry-based quantitative proteomics [PDF]

, 2012
This work was in part supported by the PRIME-XS project, grant agreement number 262067, funded by the European Union seventh Framework Programme; The Netherlands Proteomics Centre, embedded in The Netherlands Genomics Initiative; The Netherlands ...
A Alexandridou, A Gruhler, A Leitner, A Michalski, A Panchaud, A Thompson, A Wolf-Yadlin, AD Polpitiya, AHP America, AI Nesvizhskii, AI Nesvizhskii, AI Nesvizhskii, AJR Heck, Albert J. R. Heck, AM Mayampurath, B Breukelen van, B Carrillo, B Ma, B Macek, B Schwanhäusser, B Zybailov, BAP Roxas, Bas van Breukelen, BO Keller, C Christin, C Ji, C Kumar, CH Becker, CK Frese, C–C Tsou, D Chelius, D Hoof Van, D MacDougall, D Tsur, D Valkenborg, DH Lundgren, DK Han, DL Swaney, DL Tabb, DL Tabb, DM Good, DN Perkins, E Deutsch, E Qeli, EL Hendrickson, G Audi, GL Finney, H Lam, H Lam, H Liu, H Steen, H Steen, I Beer, IP Shadforth, J Cox, J Cox, J Elias, J Gouw, J Grossmann, J Klimek, J Listgarten, J Meija, J Rappsilber, J Seidler, J Zhang, JC Silva, JF Kellie, JF Timms, JV Olsen, K Flikka, K Kultima, K Podwojski, KA Neilson, KC Hansen, KL Simpson, L Martens, L Ting, LF Waanders, LK Iwai, LN Mueller, M Bantscheff, M Bantscheff, M Bern, M Junqueira, M Kohl, M Mann, M Sandin, M Senko, M Unlü, M Vandenbogaert, MA Baldwin, MA Grobei, MA Kuzyk, MC Codrea, ME Belov, ME Sardiu, MH Elliott, MJ MacCoss, MM Savitski, MW Duncan, N Colaert, N Mischerikow, N Wang, NM Griffin, OA Mirgorodskaya, P Lu, P Mallick, P Mortensen, Pedro R. Cutillas, Peter R. Baker, PJ Boersema, PL Ross, PR Baker, PR Cutillas, PR Cutillas, R Aebersold, R Clarke, R Matthiesen, R Matthiesen, R Purves, R Usaite, R Zhang, RA Bradshaw, RD Smith, RE Moore, RJ Chalkley, RJ Chalkley, RJ Jacob, S Cappadona, S Cappadona, S Carr, S Dasari, S Houel, S Julka, S Ong, S-E Ong, SA Beausoleil, SA Gerber, Salvatore Cappadona, SJ Callister, SK Park, SP Gygi, SY Ow, T Shinkawa, TM Annesley, TS Collier, TT Aye, V Faca, V Lange, VG Tusher, VP Andreev, W Weiss, W Yan, W Zhu, WM Old, WX Schulze, X Yang, Y Ishihama, Y Oda, YJ Kim, Z Khan, Z Khan, Z-Q Ma   +162 more
core   +2 more sources