Results 51 to 60 of about 383,189 (303)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility. [PDF]

, 2014
BACKGROUND: Gametogenesis and fertilization play crucial roles in malaria transmission. While male gametes are thought to be amongst the simplest eukaryotic cells and are proven targets of transmission blocking immunity, little is known about their ...
Mara Lawniczak, Wass, Mark N., Arthur M Talman, Sinden, Robert E., Prieto, Judith H, Yates, JR, Talman, Arthur M, Michael JE Sternberg, Sinden, Robert E, Stanway, RS, Graham, David R, Marques, S, Ubaida-Mohien, Ceereena, Tao Xu, Marques, Sara, Ecker, A, Sternberg, MJ, Sternberg, Michael J E, Yates, John R., III, Prieto, JH, Talman, AM, Rhoel R Dinglasan, Xu, T, Ubaida-Mohien, C, Sanjeev Krishna, Lawniczak, Mara, Wass, MN, Wass, Mark N, Dinglasan, Rhoel R, Robert E Sinden, Talman, Arthur M., Christophides, Georges K., Christophides, Georges K, Andrea Ecker, Sara Marques, Ceereena Ubaida-Mohien, Sternberg, Michael JE, Limenitakis Stanway, Rebecca, Dinglasan, Rhoel R., Georges K Christophides, Sternberg, MJE, Yates, John R, Roland Frank, Stanway, Rebecca S., Graham, David R., Xu, Tao, Frank, Roland, Prieto, Judith H., Rebecca S Stanway, Dinglasan, RR, John R Yates, Sternberg, Michael J. E., Stanway, Rebecca S, Graham, DR, Krishna, S, Mark N Wass, Christophides, GK, Lawniczak, M, Sinden, RE, Frank, R, Krishna, Sanjeev, Ecker, Andrea, David R Graham, Judith H Prieto   +63 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A proteomic glimpse into human ureter proteome [PDF]

PROTEOMICS, 2015
Urine has evolved as one of the most important biofluids in clinical proteomics due to its noninvasive sampling and its stability. Yet, it is used in clinical diagnostics of several disorders by detecting changes in its components including urinary protein/polypeptide profile.
Magdeldin, Sameh, Hirao, Yoshitoshi, Elguoshy, Amr, Xu, Bo, Zhang, Ying, Fujinaka, Hidehiko, Yamamoto, Keiko, Yates, John R., Yamamoto, Tadashi   +8 more
openaire   +2 more sources

Cerrena unicolor Laccases, Genes Expression and Regulation of Activity

Biomolecules, 2021
A white rot fungus Cerrena unicolor has been identified as an important source of laccase, unfortunately regulation of this enzyme genes expression is poorly understood.
Anna Pawlik, Beata Ciołek, Justyna Sulej, Andrzej Mazur, Przemysław Grela, Magdalena Staszczak, Mateusz Niścior, Magdalena Jaszek, Anna Matuszewska, Grzegorz Janusz, Andrzej Paszczyński   +10 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Research Progress on Regulatory Mechanisms of Conical Cell Morphogenesis in Arabidopsis thaliana

Plants
Flowering plants are universally adorned with conical epidermal cells on their petals, which play a pivotal role in their function. They modulate the petal microenvironment by regulating wetting and temperature homeostasis and enhance pollinator ...
Xinfei Li, Deshu Lin, Lilan Zhu
doaj   +1 more source

Isolation of Stem Cells of the Degenerated Lumbar Intervertebral Disc Using a Low Cost and Very Effective Technique

Global Spine Journal, 2014
Introduction The limitations of regenerative therapy of the tissue using stem cells are, among others, the length of time until a satisfactory amount of viable cells is obtained for the therapy and the high financial cost.
A. Falavigna, M. Peletti-Figueiró, I. Silvera Aguiar, M. Roesch-Ely, D. Cantarelli Machado, J. A. Pêgas Henriques   +5 more
doaj   +1 more source

Transcriptomic and proteomic analysis of Oenococcus oeni adaptation to wine stress conditions

Frontiers in Microbiology, 2016
Oenococcus oeni, the main lactic acid bacteria responsible for malolactic fermentation in wine, has to adapt to stressful conditions, such as low pH and high ethanol content. In this study, the changes in the transcriptome and the proteome of O. oeni PSU-
Mar Margalef-Català, Isabel Araque, Albert Bordons, Cristina Reguant, Joaquin Bautista-Gallego   +4 more
doaj   +1 more source

Bacterial proteomic workflow

, 2018
This protocol desribes the bacterial proteomic workflow used in the article: "The use of SWATH to analyse the dynamic changes of bacterial proteome of carbapenemase-producing Escherichia coli under antibiotic pressure" published in Scientific Reports.
Sidjabat, Hanna
core   +1 more source