Results 31 to 40 of about 591,485 (302)

Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis

bioRxiv, 2020
Cytoplasmic stress granules (SG) form in response to a variety of cellular stresses by phase-separation of proteins associated with non-translating mRNAs.
Hagai Marmor-Kollet, Aviad Siany, N. Kedersha, Naama Knafo, Natalia Rivkin, Yehuda M. Danino, T. Moens, T. Olender, Daoud Sheban, Nir Cohen, Tali Dadosh, Yoseph Addadi, Revital Ravid, Chen Eitan, Beata Toth Cohen, Sarah Hofmann, Claire L. Riggs, Vivek M. Advani, A. Higginbottom, J. Cooper-Knock, Jacob H. Hanna, Yifat Merbl, L. Van Den Bosch, P. Anderson, P. Ivanov, T. Geiger, E. Hornstein   +26 more
semanticscholar   +1 more source

Proteomic analysis for the study of amniotic fluid protein composition [PDF]

, 2009
Amniotic fluid (AF), routinely used for prenatal diagnosis, contains large amounts of proteins produced by the amnion epithelial cells, fetal tissues, fetal excretions and placental tissues. Although many amniotic fluid proteins have been identified and
Giorlandino, Claudio, Mesoraca, Alvaro, Perluigi, Marzia, Cini, Chiara, Di Domenico, Fabio, Giorlandino, Maurizio, Coccia, Raffaella, Giorlandino, Francesca Romana, Cignini, Piero   +8 more
core   +1 more source

Allogeneic Antigen Composition for Preparing Universal Cancer Vaccines

Journal of Immunology Research, 2016
Recently it was demonstrated that tumors induce specific changes to the surface of human endothelial cells thereby providing the basis for designing endothelial cell-based vaccines that directly target antigens expressed by the tumor endothelium.
Petr G. Lokhov, Elena E. Balashova
doaj   +1 more source

The Effect of Neurotoxin MPTP and Neuroprotector Isatin on the Profile of Ubiquitinated Brain Mitochondrial Proteins

Cells, 2018
Mitochondria are a crucial target for the actions of neurotoxins, causing symptoms of Parkinson’s disease in various experimental animal models, and also neuroprotectors.
Olga Buneeva, Arthur Kopylov, Inga Kapitsa, Elena Ivanova, Victor Zgoda, Alexei Medvedev   +5 more
doaj   +1 more source

Multiple short windows of calcium-dependent protein kinase 4 activity coordinate distinct cell cycle events during Plasmodium gametogenesis

eLife, 2017
Malaria transmission relies on the production of gametes following ingestion by a mosquito. Here, we show that Ca2+-dependent protein kinase 4 controls three processes essential to progress from a single haploid microgametocyte to the release of eight ...
Hanwei Fang, Natacha Klages, Bastien Baechler, Evelyn Hillner, Lu Yu, Mercedes Pardo, Jyoti Choudhary, Mathieu Brochet   +7 more
doaj   +1 more source

Differential Proteomic Expression of Equine Cardiac and Lamellar Tissue During Insulin-Induced Laminitis

Frontiers in Veterinary Science, 2020
Endocrinopathic laminitis is pathologically similar to the multi-organ dysfunction and peripheral neuropathy found in human patients with metabolic syndrome.
Allison Campolo, Matthew W. Frantz, Melody A. de Laat, Melody A. de Laat, Steven D. Hartson, Martin O. Furr, Véronique A. Lacombe   +6 more
doaj   +1 more source

Pan-cancer molecular subtypes revealed by mass-spectrometry-based proteomic characterization of more than 500 human cancers

Nature Communications, 2019
Mass-spectrometry-based proteomic profiling of human cancers has the potential for pan-cancer analyses to identify molecular subtypes and associated pathway features that might be otherwise missed using transcriptomics.
Fengju Chen, D. Chandrashekar, S. Varambally, C. Creighton   +3 more
semanticscholar   +1 more source

Plasma proteomic biomarker signature of age predicts health and life span

eLife, 2020
Older age is a strong shared risk factor for many chronic diseases, and there is increasing interest in identifying aging biomarkers. Here, a proteomic analysis of 1301 plasma proteins was conducted in 997 individuals between 21 and 102 years of age.
Toshiko Tanaka, N. Basisty, G. Fantoni, Julián Candia, A. Moore, Angelique Biancotto, B. Schilling, S. Bandinelli, L. Ferrucci   +8 more
semanticscholar   +1 more source

Profiling plasma‐extracellular vesicle proteins and microRNAs in diabetes onset in middle‐aged male participants in the ELSA‐Brasil study

Physiological Reports, 2021
We measured plasma‐derived extracellular vesicle (EV) proteins and their microRNA (miRNA) cargos in normoglycemic (NG), glucose intolerant (GI), and newly diagnosed diabetes mellitus (DM) in middle‐aged male participants of the Brazilian Longitudinal ...
Laureane N. Masi, Paulo A. Lotufo, Frederico M. Ferreira, Alice C. Rodrigues, Tamires D. A. Serdan, Talita Souza‐Siqueira, Aécio A. Braga, Magda E. G. Saldarriaga, Tatiana C. Alba‐Loureiro, Fernanda T. Borges, Diego P. Cury, Mario H. Hirata, Renata Gorjão, Tania C. Pithon‐Curi, Simão A. Lottenberg, Ligia M. G. Fedeli, Helder T. I. Nakaya, Isabela J. M. Bensenor, Rui Curi, Sandro M. Hirabara   +19 more
doaj   +1 more source

Proteomic and metabolomic analysis of Nicotiana benthamiana under dark stress

FEBS Open Bio, 2022
Exposure to extended periods of darkness is a common source of abiotic stress that significantly affects plant growth and development. To understand how Nicotiana benthamiana responds to dark stress, the proteomes and metabolomes of leaves treated with ...
Juan‐Juan Shen, Qian‐Si Chen, Ze‐Feng Li, Qing‐Xia Zheng, Ya‐Long Xu, Hui‐Na Zhou, Hong‐Yan Mao, Qi Shen, Ping‐Ping Liu   +8 more
doaj   +1 more source