Results 11 to 20 of about 591,485 (302)

Development and evaluation of statistical approaches in proteomic biomarker discovery [PDF]

, 2011
A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes or pharmacological responses to a therapeutic intervention.
Patel, Amit
core   +7 more sources

Large-scale Proteomic Analysis of Alzheimer’s Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation

Nature Medicine, 2020
Our understanding of Alzheimer’s disease (AD) pathophysiology remains incomplete. Here we used quantitative mass spectrometry and coexpression network analysis to conduct the largest proteomic study thus far on AD.
E. Johnson, E. Dammer, D. Duong, L. Ping, Mao-Tian Zhou, Luming Yin, L. Higginbotham, Andrew Guajardo, Bartholomew White, J. Troncoso, M. Thambisetty, T. Montine, Edward B. Lee, J. Trojanowski, T. Beach, E. Reiman, V. Haroutunian, Minghui Wang, E. Schadt, Bin Zhang, D. Dickson, N. Ertekin-Taner, T. Golde, V. Petyuk, P. D. De Jager, D. Bennett, T. Wingo, S. Rangaraju, I. Hajjar, J. Shulman, J. Lah, A. Levey, N. Seyfried   +32 more
semanticscholar   +1 more source

Integrative Proteomic Characterization of Human Lung Adenocarcinoma.

Cell, 2020
Genomic studies of lung adenocarcinoma (LUAD) have advanced our understanding of the disease's biology and accelerated targeted therapy. However, the proteomic characteristics of LUAD remain poorly understood.
Jun-Ming Xu, Chun-Chao Zhang, Xiang Wang, Lin-Hui Zhai, Yiming Ma, You-Sheng Mao, K. Qian, Changqing Sun, Zhiwei Liu, Shangwen Jiang, Ming-Hui Wang, Lin Feng, Lei Zhao, Ping Liu, Bo Wang, Xin Zhao, Hui Xie, Xiaoyun Yang, Liyuan Zhao, Ya-Fei Chang, Jin-hui Jia, Xi-Jun Wang, Yimin Zhang, Yaru Wang, Yikun Yang, Zhi-Xiang Wu, Longhai Yang, Bin Liu, Teng Zhao, Sheng-Guo Ren, A. Sun, Yang Zhao, W. Ying, Fei Wang, Guangshun Wang, Yi Zhang, Shujun Cheng, J. Qin, X. Qian, Yi Wang, Jing Li, F. He, T. Xiao, Minjia Tan   +43 more
semanticscholar   +1 more source

Proteomic and phosphoproteomic landscapes of acute myeloid leukemia

Blood, 2022
Key Points A deep-scale proteomic and phosphoproteomic database of AML was produced and can be explored interactively (www.leylab.org/amlproteome).
Michael H. Kramer, Qiang Zhang, R. Sprung, Ryan B Day, Petra Erdmann-Gilmore, Yang Li, Zi-Heng Xu, Nichole M. Helton, Daniel R. George, Yiling Mi, P. Westervelt, J. Payton, S. M. Ramakrishnan, Christopher A. Miller, D. Link, J. Dipersio, M. Walter, R. Townsend, T. Ley   +18 more
semanticscholar   +1 more source

Mengchao-Hepatobiliary-Hospital/HCC-proteomic-subtypes: v1.0

, 2023
2022112
HCC proteomic subtype
core   +1 more source

Ground Demonstration of the Use of Limnospira indica for Air Revitalization in a Bioregenerative Life-Support System Setup: Effect of Non-Nitrified Urine–Derived Nitrogen Sources

Frontiers in Astronomy and Space Sciences, 2021
Long-duration human space missions require considerable amounts of water, oxygen, and nutritious biomass. Additionally, the space vehicles must be well equipped to deal with metabolic human waste. It is therefore important to develop life-support systems
Neha Sachdeva, Laurent Poughon, Olivier Gerbi, Claude-Gilles Dussap, Christophe Lasseur, Baptiste Leroy, Ruddy Wattiez   +6 more
doaj   +1 more source

Multi-organ proteomic landscape of COVID-19 autopsies

medRxiv, 2020
The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear, preventing effective therapeutics development. Here, we report an in-depth multi-organ proteomic landscape of COVID-19 patient autopsy samples.
X. Nie, Liujia Qian, Rui Sun, Bo Huang, Xiaochuan Dong, Qi Xiao, Qiu-Shi Zhang, T. Lu, Liang Yue, Shuo Chen, Xiang Li, Yao-Ting Sun, Lu Li, Luang Xu, Yan Li, Ming Yang, Z. Xue, Shuang Liang, Xuan Ding, Chunhui Yuan, Li Peng, Wei Liu, Xiao Yi, Mengge Lyu, Gui-Xiang Xiao, Xia Xu, W. Ge, Jia-Le He, Jun Fan, Junhua Wu, M. Luo, Xiaona Chang, Huaxiong Pan, Xue Cai, Jun-Jie Zhou, Jing Yu, Huanhuan Gao, M. Xie, Si-Hua Wang, Guan Ruan, Hao Chen, Hua Su, H. Mei, Dan-Ju Luo, Dashi Zhao, Fei Xu, Y. Zhu, Jiahong Xia, Yu Hu, Tiannan Guo   +49 more
semanticscholar   +1 more source

Endometrial proteomic profile of patients with repeated implantation failure

Frontiers in Endocrinology, 2023
IntroductionSuccessful embryo implantation, is the initiating step of pregnancy, relies on not only the high quality of the embryo but also the synergistic development of a healthy endometrium.
Jing Yang, Linlin Wang, Linlin Wang, Linlin Wang, Jingwen Ma, Lianghui Diao, Lianghui Diao, Jiao Chen, Yanxiang Cheng, Jing Yang, Longfei Li, Longfei Li   +11 more
doaj   +1 more source

Diagnostics and correction of batch effects in large‐scale proteomic studies: a tutorial

Molecular Systems Biology, 2021
Advancements in mass spectrometry‐based proteomics have enabled experiments encompassing hundreds of samples. While these large sample sets deliver much‐needed statistical power, handling them introduces technical variability known as batch effects. Here,
Jelena Čuklina, C. Lee, Evan G. Williams, Tatjana Sajic, Ben C. Collins, María Rodríguez Martínez, Varun S. Sharma, Fabian Wendt, S. Goetze, G. Keele, B. Wollscheid, R. Aebersold, Patrick G. A. Pedrioli   +12 more
semanticscholar   +1 more source

Unbiased Proteomic Approach Identifies Unique and Coincidental Plasma Biomarkers in Repetitive mTBI and AD Pathogenesis

Frontiers in Aging Neuroscience, 2018
The relationship between repetitive mild traumatic brain injury (r-mTBI) and Alzheimer’s disease (AD) is well-recognized. However, the precise nature of how r-mTBI leads to or precipitates AD pathogenesis is currently not understood.
Joseph O. Ojo, Joseph O. Ojo, Joseph O. Ojo, Gogce Crynen, Gogce Crynen, Jon M. Reed, Jon M. Reed, Rosa Ajoy, Prashanthi Vallabhaneni, Moustafa Algamal, Moustafa Algamal, Paige Leary, Naomi G. Rafi, Benoit Mouzon, Benoit Mouzon, Benoit Mouzon, Michael Mullan, Michael Mullan, Fiona Crawford, Fiona Crawford, Fiona Crawford   +20 more
doaj   +1 more source