Results 41 to 50 of about 591,485 (302)
Plasma proteomic signature of age in healthy humans
Aging Cell, 2018 To characterize the proteomic signature of chronological age, 1,301 proteins were measured in plasma using the SOMAscan assay (SomaLogic, Boulder, CO, USA) in a population of 240 healthy men and women, 22–93 years old, who were disease‐ and treatment ...
Toshiko Tanaka +11 more
semanticscholar +1 more source
Data in Brief, 2016 This data article describes a controlled, spiked proteomic dataset for which the “ground truth” of variant proteins is known. It is based on the LC-MS analysis of samples composed of a fixed background of yeast lysate and different spiked amounts of the ...
Claire Ramus +17 more
doaj +1 more source
The Role of the Nuclear Receptor FXR in Arsenic-Induced Glucose Intolerance in Mice
Toxics, 2023 Inorganic arsenic in drinking water is prioritized as a top environmental contaminant by the World Health Organization, with over 230 million people potentially being exposed. Arsenic toxicity has been well documented and is associated with a plethora of
Yifei Yang +3 more
doaj +1 more source
Soluble CD72, is a T-cell activator probably via binding to CD6 in homeostasis and autoimmunity
Frontiers in ImmunologyBackgroundCD72 is a highly required regulatory molecule in B cells. Its sufficient expression is crucial for maintaining self-tolerance. In contrast, soluble CD72 (sCD72) is reported to be increased in the serum of autoimmune diseases such as systemic ...
Nasren Eiza +6 more
doaj +1 more source
Scientific Reports, 2017 MYST histone acetyltransferases have crucial functions in transcription, replication and DNA repair and are hence implicated in development and cancer.
Mercedes Pardo +8 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2021 Multiple myeloma (MM) is the second most frequent hematologic cancer in the United States. Carfilzomib (CFZ), an irreversible proteasome inhibitor being used to treat relapsed and refractory MM, has been associated with cardiotoxicity, including heart ...
Marwa Tantawy +19 more
doaj +1 more source
Acquisition and Analysis of DIA-Based Proteomic Data: A Comprehensive Survey in 2023
Molecular & Cellular ProteomicsData-independent acquisition (DIA) mass spectrometry (MS) has emerged as a powerful technology for high-throughput, accurate, and reproducible quantitative proteomics.
Ronghui Lou, W. Shui
semanticscholar +1 more source
Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin
Nature Communications, 2020 Human skin provides both physical integrity and immunological protection from the external environment using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human health and disease, the constituent proteins
B. Dyring-Andersen +13 more
semanticscholar +1 more source
Utilising proteomic approaches to understand oncogenic human herpesviruses [PDF]
, 2014 The γ‑herpesviruses Epstein-Barr virus and Kaposi's sarcoma‑associated herpesvirus are successful pathogens, each infecting a large proportion of the human population.
Owen, Christopher B +13 more
core +1 more source
Single-cell long-read targeted sequencing reveals transcriptional variation in ovarian cancer
Nature CommunicationsSingle-cell RNA sequencing predominantly employs short-read sequencing to characterize cell types, states and dynamics; however, it is inadequate for comprehensive characterization of RNA isoforms. Long-read sequencing technologies enable single-cell RNA
Ashley Byrne +12 more
doaj +1 more source