Results 231 to 240 of about 22,304,287 (299)

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source

Proteomic analysis identifies pathways related to immune dysregulation in patients with hematologic malignancies after COVID-19 infection. [PDF]

Microbiol Spectr
Tang B, Yang X, Tian W, Zhu J, Liu W, Di M, Liu H, Liang Z, Chen Y, Dong Y.   +9 more
europepmc   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Magnetic-Assisted Aptamer Selection and Isolation of Migrasomes for Application in Lung Adenocarcinoma Proteomic Analysis. [PDF]

J Extracell Vesicles
Xu Y, Jiao L, Yi Q, Chen Y, Cai B, Zhang J, Huang Z, Luo Y, Si Y, Wu Y, Ying B, Chen J, Zhou J.   +12 more
europepmc   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Transcriptomic and proteomic analysis of osteogenesis imperfecta disease-specific induced pluripotent stem cells. [PDF]

BMC Med Genomics
Guo R, Huang L, Sha Y, Mo C, Li C, Gong W, Hou X, Ou M.   +7 more
europepmc   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Integrated longitudinal transcriptomic and proteomic analysis of the murine lung response to influenza a virus. [PDF]

Am J Respir Cell Mol Biol
Flerlage T, Boyd DF, Clark B, Marudai NG, Saini S, Guy C, Pobre-Piza K, Crawford JC, Poudel S, High AA, Zhou S, Wang X, Surman S, Jones B, Frevert CW, Thomas PG.   +15 more
europepmc   +1 more source

Proteomic analysis of cisplatin-induced spermatogenesis defects in mice. [PDF]

Ann Med
Li P, Chen Z, Zhang Z, Li H, Zhang Y.
europepmc   +1 more source

Integrated transcriptomic and proteomic analysis reveals the regulatory role of exogenous gibberellin in sugarcane internode maturation. [PDF]

Front Plant Sci
Chen R, Wu Z, Lai Z, Wen J, Dong W, Liao J, Wu Y, Chen J, Que Y, Wu J, Fan Y.   +10 more
europepmc   +1 more source