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Current Protocols in Protein Science, 2002
AbstractThis unit reviews the new discipline of proteomics, which includes any large‐scale protein‐based systematic analysis of the proteome or defined sub‐proteome from a cell, tissue, or entire organism. Proteomics originated in the mid‐1990s due to two key enabling advances, availability of complete genome sequences, and mass spectrometry advances ...
Nadeem, Ali-Khan +2 more
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AbstractThis unit reviews the new discipline of proteomics, which includes any large‐scale protein‐based systematic analysis of the proteome or defined sub‐proteome from a cell, tissue, or entire organism. Proteomics originated in the mid‐1990s due to two key enabling advances, availability of complete genome sequences, and mass spectrometry advances ...
Nadeem, Ali-Khan +2 more
openaire +2 more sources
British Journal of Neurosurgery, 2007
Primary malignant brain tumours (anaplastic glioma and glioblastoma) display heterogenous histopathology and diverse genetic abnormalities. These tumours remain incurable with no significant improvement in median survival times in the last 20 years, despite significant technological advances in surgery and radiotherapy, and mechanistic insights into ...
I R, Whittle +5 more
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Primary malignant brain tumours (anaplastic glioma and glioblastoma) display heterogenous histopathology and diverse genetic abnormalities. These tumours remain incurable with no significant improvement in median survival times in the last 20 years, despite significant technological advances in surgery and radiotherapy, and mechanistic insights into ...
I R, Whittle +5 more
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Proteomic analysis of meningiomas
Acta Neurologica Belgica, 2013Meningiomas represent one-third of all primary brain tumors and cause 35,000 new cases each year. Because of this high incidence, we sought to determine if there are proteomic differences between meningiomas and neighboring tissues. Two-dimensional gel electrophoresis and mass spectrometry were used to detect differentially expressed proteins in tumor ...
G Q, Cui +6 more
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Analysis of the microbial proteome
Current Opinion in Microbiology, 2000Proteomics has begun to provide insight into the biology of microorganisms. The combination of proteomics with genetics, molecular biology, protein biochemistry and biophysics is particularly powerful, resulting in novel methods to analyse complex protein mixtures.
M P, Washburn, J R, Yates
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Phytoplasma Proteomic Analysis
2012Proteome analysis is becoming a powerful tool in the functional characterization of organisms, and takes a broad, comprehensive, systematic approach to understanding biology. Following the sequencing of the phytoplasma genomes, the next step is to characterize the expressed proteome of phytoplasmas to acquire the verification and functional annotation ...
Xianling, Ji, Yingping, Gai
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Proteome analysis of adipogenesis
PROTEOMICS, 2004AbstractAdipose tissue plays a crucial endocrine role in controlling whole body glucose homeostasis and insulin sensitivity. Given the substantial rise in obesity and obesity‐related diseases such as diabetes, it is important to understand the molecular basis of adipocyte differentiation and its control.
Welsh, GI +4 more
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2013
This chapter discusses the methods for analysing the proteome which refers to the total protein content of cells or tissues. It examines the weaknesses and strengths of these methods to guide readers in choosing an appropriate one that would answer a particular biological question.
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This chapter discusses the methods for analysing the proteome which refers to the total protein content of cells or tissues. It examines the weaknesses and strengths of these methods to guide readers in choosing an appropriate one that would answer a particular biological question.
openaire +3 more sources
Cardiovascular proteomic analysis
Journal of Chromatography B, 2007Here, we report on our proteomic studies in the field of cardiovascular medicine. Our research has been focused on understanding the role of proteins in cardiovascular disease with a particular focus on epigenetic regulation and biomarker discovery, with the objective of better understanding cardiovascular pathophysiology to lead to the development of ...
Toru, Suzuki, Ryozo, Nagai
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PROTEOMICS, 2004
Abstract Proteome analysis is becoming a powerful tool in the functional characterization of plants. Due to the availability of vast nucleotide sequence information and based on the progress achieved in sensitive and rapid protein identification by mass spectrometry, proteome approaches open up new perspectives to analyze the complex ...
Canovas, F.M. +5 more
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Abstract Proteome analysis is becoming a powerful tool in the functional characterization of plants. Due to the availability of vast nucleotide sequence information and based on the progress achieved in sensitive and rapid protein identification by mass spectrometry, proteome approaches open up new perspectives to analyze the complex ...
Canovas, F.M. +5 more
openaire +3 more sources
PROTEOMICS, 2004
AbstractThis report provides the first proteomic analysis of normal ovine lymph. By establishing the fact that lymph is more than an ultrafiltrate of blood plasma, it documents that the lymph proteome contains an array of proteins that differentiates it from plasma.
Lee V, Leak +8 more
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AbstractThis report provides the first proteomic analysis of normal ovine lymph. By establishing the fact that lymph is more than an ultrafiltrate of blood plasma, it documents that the lymph proteome contains an array of proteins that differentiates it from plasma.
Lee V, Leak +8 more
openaire +2 more sources