Results 191 to 200 of about 490,947 (358)

Genomics, proteomics, bioinformatics and developmental toxicology in the twenty-first century [PDF]

, 2000
Helmut Zarbl, Aravinda Chakravarti, John R. Yates, Mark S. Boguski, William B. Mattes, Pharmacia Upjohn, Lance A. Liotta, Thomas B. Knudsen, Janee Gelineau‐van Waes, Dan Liebler, Jim Eudyk, Philip E. Mirkes   +11 more
openalex   +1 more source

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source

Quantitative Proteomics of the Cancer Cell Line Encyclopedia

Cell, 2020
David P. Nusinow, John Szpyt, M. Ghandi, Christopher M. Rose, E. McDonald, M. Kalocsay, Judit Jané-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, J. Golji, D. Porter, T. Rejtar, Y. K. Wang, G. Kryukov, F. Stegmeier, B. Erickson, Levi A. Garraway, Levi A. Garraway, W. Sellers, S. Gygi   +20 more
semanticscholar   +1 more source

Ultra-fast proteomics with Scanning SWATH

Nature Biotechnology, 2021
Christoph B. Messner, V. Demichev, N. Bloomfield, Jason S. L. Yu, M. White, Marco Kreidl, Anna-Sophia Egger, A. Freiwald, Gordana Ivosev, Fras Wasim, Aleksej Zelezniak, Linda Jürgens, N. Suttorp, L. Sander, F. Kurth, K. Lilley, M. Mülleder, S. Tate, M. Ralser   +18 more
semanticscholar   +1 more source

CCL20/CXCL5 Drives Crosstalk Between Anaplastic Thyroid Cancer Stem Cells and Tumor‐Associated Macrophages to Promote Tumor Progression

Advanced Science, EarlyView.
This study elucidates the crosstalk between tumor‐associated macrophages (TAMs) and anaplastic thyroid cancer stem cells (ATCSCs). The findings reveal that CCL20 from THP‐1‐M2 activates the IRAK‐1/NF‐κB1/2 pathway in ATCSCs, thereby enhancing CXCL5 secretion.
Qi Liu, Yan Wang, Mingyuan Song, Jiapeng Huang, Jinyuan Shi, Wei Sun, Xiaoyu Ji, Yuang Chang, Bing Ma, Ping Zhang, Yuanyuan Yan, Hao Zhang   +11 more
wiley   +1 more source

Automating Exploratory Proteomics Research via Language Models [PDF]

arXiv
With the development of artificial intelligence, its contribution to science is evolving from simulating a complex problem to automating entire research processes and producing novel discoveries. Achieving this advancement requires both specialized general models grounded in real-world scientific data and iterative, exploratory frameworks that mirror ...
arxiv  

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Towards functional proteomics of membrane protein complexes: analysis of thylakoid membranes from Chlamydomonas reinhardtii [PDF]

, 2001
Michael Hippler, Jens Klein, Andréas Fink, Tanja Allinger, Patric Hoerth   +4 more
openalex   +1 more source

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction

Advanced Science, EarlyView.
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu, Peng Peng, Changze Wei, Fanhui Meng, Xiaoyao Huang, Peisheng Liu, Siyuan Fan, Xinyue Cai, Meiling Wu, Zilin Xuan, Qing Liu, Xinyu Qiu, Zhenlai Zhu, Hao Guo   +13 more
wiley   +1 more source

Cell wall-active antibiotic induced proteins of Staphylococcus aureus identified using a proteomic approach1 [PDF]

, 2001
Vineet K. Singh, Radheshyam K. Jayaswal, Brian J. Wilkinson   +2 more
openalex   +1 more source