Results 221 to 230 of about 784,733 (395)

FAS-cinating proteomics [PDF]

, 2000
Jonathan B Weitzman
openalex   +1 more source

Mechanochemistry: Fundamental Principles and Applications

Advanced Science, EarlyView.
In this review, the physicochemical principles of mechanochemistry are first clarified. Based on this foundation, the research basis and cutting‐edge scientific achievements in four areas are introduced: solid‐state organic chemistry, polymers, interface science, and biomechanochemistry.
Liang Dong, Luofei Li, Huiyan Chen, Yi Cao, Hai Lei   +4 more
wiley   +1 more source

Deep Learning in Proteomics Informatics: Applications, Challenges, and Future Directions [PDF]

arXiv
Deep learning is an advanced technology that relies on large-scale data and complex models for feature extraction and pattern recognition. It has been widely applied across various fields, including computer vision, natural language processing, and speech recognition. In recent years, deep learning has demonstrated significant potential in the realm of
arxiv  

Philosopher: a versatile toolkit for shotgun proteomics data analysis

Nature Methods, 2020
Felipe da Veiga Leprevost, Sarah E. Haynes, D. Avtonomov, Hui-Yin Chang, A. Shanmugam, Dattatreya Mellacheruvu, Andy T. Kong, A. Nesvizhskii   +7 more
semanticscholar   +1 more source

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source

Single-Cell Proteomics Using Mass Spectrometry [PDF]

arXiv
Single-cell proteomics (SCP) is transforming our understanding of biological complexity by shifting from bulk proteomics, where signals are averaged over thousands of cells, to the proteome analysis of individual cells. This granular perspective reveals distinct cell states, population heterogeneity, and the underpinnings of disease pathogenesis that ...
arxiv  

Genomics, proteomics, bioinformatics and developmental toxicology in the twenty-first century [PDF]

, 2000
Helmut Zarbl, Aravinda Chakravarti, John R. Yates, Mark S. Boguski, William B. Mattes, Pharmacia Upjohn, Lance A. Liotta, Thomas B. Knudsen, Janee Gelineau‐van Waes, Dan Liebler, Jim Eudyk, Philip E. Mirkes   +11 more
openalex   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction

Advanced Science, EarlyView.
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu, Peng Peng, Changze Wei, Fanhui Meng, Xiaoyao Huang, Peisheng Liu, Siyuan Fan, Xinyue Cai, Meiling Wu, Zilin Xuan, Qing Liu, Xinyu Qiu, Zhenlai Zhu, Hao Guo   +13 more
wiley   +1 more source

Automating Exploratory Proteomics Research via Language Models [PDF]

arXiv
With the development of artificial intelligence, its contribution to science is evolving from simulating a complex problem to automating entire research processes and producing novel discoveries. Achieving this advancement requires both specialized general models grounded in real-world scientific data and iterative, exploratory frameworks that mirror ...
arxiv