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Prothrombin Segovia: A new congenital abnormality of prothrombin
Scandinavian Journal of Haematology, 1986A family with a new congenital dysprothrombinemia is presented. The propositus is a 21‐yr‐old man who presented simultaneously with hemartrosis of the left knee and an extensive hematoma following a minor trauma. Prothrombin time and activated partial thromboplastin time were prolonged.
E, Rocha +5 more
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Prothrombin madrid : A new familial abnormality of prothrombin
Thrombosis Research, 1979Abstract An abnormal prothrombin has been detected in a 13 yr-old girl, with history of excessive bleeding. Prothrombin time and activated partial thromboplastin time were markedly prolonged. Prothrombin activity was very low when measured by biological assay using either physiological activators (3% by one stage assay and 20 US u/ml by two stage ...
A, Bezeaud +4 more
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Prothrombin A19911G polymorphism and the risk of venous thromboembolism [PDF]
Journal of Thrombosis and Haemostasis, 2006 Background: The A &rt; G polymorphism at position 19911 of the prothrombin gene is associated with increased plasma prothrombin levels but its role as a risk factor for venous thromboembolism (VTE) is not established.
Ida Martinelli +2 more
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Prothrombin Poissy: a new variant of human prothrombin
British Journal of Haematology, 1987SummaryA new congenital dysprothrombinaemia is described in a newborn baby girl who presented severe bleeding from the second day of life. Routine coagulation tests showed very prolonged prothrombin time and activated partial thromboplastin time with about 2% prothrombin activity in a one‐stage assay.
M D, Dumont +5 more
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Decarboxylation of bovine prothrombin fragment 1 and prothrombin
Biochemistry, 1979Bovine prothrombin fragment 1 and prothrombin undergo decarboxylation of their gamma-carboxyglutamic acid residues when the lyophilized proteins are heated in vacuo at 110 degrees C for several hours. The fully decarboxylated fragment 1 product has lost its barium-binding ability as well as the calcium-binding function which causes fluorescence ...
P M, Tuhy, J W, Bloom, K G, Mann
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Lupus, 2012
Research on antiphospholipid antibodies (aPL) and the thrombotic manifestations associated with these antibodies has grown since the description of anticardiolipin antibodies (aCL) by Harris and colleagues in the early 1980s. Antiprothrombin (aPT) antibodies are commonly detected by ELISA, using irradiated plates (aPT) or prothrombin in complex with ...
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Research on antiphospholipid antibodies (aPL) and the thrombotic manifestations associated with these antibodies has grown since the description of anticardiolipin antibodies (aCL) by Harris and colleagues in the early 1980s. Antiprothrombin (aPT) antibodies are commonly detected by ELISA, using irradiated plates (aPT) or prothrombin in complex with ...
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Congenital Prothrombin Deficiency
Seminars in Thrombosis and Hemostasis, 2009Prothrombin deficiency is among the rarest inherited coagulation disorders, with a prevalence of approximately 1:2,000,000. Two main phenotypes can be distinguished: (1) hypoprothrombinemia (type I deficiency), characterized by concomitantly low levels of activity and antigen; and (2) dysprothrombinemia (type II deficiency), characterized by the normal
Lancellotti, Stefano +1 more
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Journal of the American Medical Association, 1947
To the Editor:— The recent current comment on Stability of Prothrombin inThe Journal, September 9, page 36, contains Certain statements to which I am compelled to take exception; particularly to one: "Unreliable values for prothrombin obtained by the one stage method etc." It might be well to inquire concerning the actual facts.
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To the Editor:— The recent current comment on Stability of Prothrombin inThe Journal, September 9, page 36, contains Certain statements to which I am compelled to take exception; particularly to one: "Unreliable values for prothrombin obtained by the one stage method etc." It might be well to inquire concerning the actual facts.
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[Rinsho ketsueki] The Japanese journal of clinical hematology, 2021
Dysprothrombinemia is the rarest inherited bleeding disorder that is characterized by a decrease in the prothrombin activity, but normal antigen levels. In this study, we report the case of a compound heterozygote of two mutations in prothrombin; Met337Thr and Arg388His, which has previously been identified as "Prothrombin Himi." A systemic blood ...
Yusuke, Kamihara +7 more
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Dysprothrombinemia is the rarest inherited bleeding disorder that is characterized by a decrease in the prothrombin activity, but normal antigen levels. In this study, we report the case of a compound heterozygote of two mutations in prothrombin; Met337Thr and Arg388His, which has previously been identified as "Prothrombin Himi." A systemic blood ...
Yusuke, Kamihara +7 more
openaire +1 more source