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Activation of Prothrombin [PDF]

American Journal of Physiology-Legacy Content, 1956
In the activation of a prothrombin solution, only part of the prothrombin becomes biothrombin, some becomes autoprothrombin I and some becomes autoprothrombin II. Thrombin-thrombin is also obtained, and perhaps other derivatives of prothrombin are formed. Prothrombin thus has multiple potentialities and these can be developed in diverse ways.
J A, PENNER, W H, SEEGERS
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Activation of Prothrombin [PDF]

American Journal of Physiology-Legacy Content, 1958
In experiments with purified biothrombin, it was found that strong solutions of sodium citrate or protamine sulfate (0.1% w/v) or purified platelet factor 3 depress the esterase activity and leave the clotting power unaltered. Apparently a depression of esterase activity is beneficial for the autocatalytic activation of purified prothrombin.
R H, LANDABURU, W H, SEEGERS
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THE ACETYLATION OF PROTHROMBIN [PDF]

Canadian Journal of Biochemistry and Physiology, 1960
Purified bovine prothrombin was acetylated to a range of 27 to 30% of its amino groups. Except for just significant amounts it lost its power to generate thrombin-C. Upon activation the yield of thrombin-E was 100% on the basis of the thrombin-C yield that was obtained on an aliquot sample of the prothrombin before acetylation.
R H, LANDABURU, W H, SEEGERS
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Estimation of Prothrombin Level from Prothrombin Time*

American Journal of Clinical Pathology, 1947
Rosenfield Richard E
exaly   +3 more sources

Prothrombin synthesis in the dog [PDF]

American Journal of Physiology, 1964
Liver parenchymal cells were found to be the sites for production of prothrombin. Dogs were employed and their rate of prothrombin synthesis was modified as desired by giving either Coumadin or vitamin K1.
Marion I Barnhart, M I Barnhart, Gordon F Anderson   +2 more
exaly   +2 more sources

Prothrombin Activity and Concentration in Healthy Subjects with and without the Prothrombin G20210A Mutation [PDF]

Thrombosis Research, 2000
A common mutation in the prothrombin gene (G20210A) is associated with elevated prothrombin levels and thrombosis. The pathomechanism related to the G20210A mutation is currently not understood and the interdependence of prothrombin activity and ...
Hannelore Ehrenreich, Piotr Lewczuk, E Schutz   +2 more
exaly   +2 more sources

The Prothrombin Gene

Haemostasis, 2009
Using recombinant DNA techniques, DNA fragments coding for bovine prothrombin mRNA have been cloned and characterized. Structural studies have revealed that prothrombin mRNA encodes a precursor protein having an amino-terminal extension of 43 amino acid residues.
R T, MacGillivray, D M, Irwin
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The Biology of Prothrombin

Critical Reviews™ in Eukaryotic Gene Expression, 1998
Prothrombin and thrombin are involved in diverse biological functions. The structure of prothrombin has been studied extensively and its cDNA has been cloned from several species. The tissue-specific expression of this protein has been studied, as well as the developmental expression pattern.
S J, Degen, W Y, Sun
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Electroimmunoassay of prothrombin

Thrombosis Research, 1987
Electroimmunoassay of normal (10-Gla) and Gla-deficient prothrombins containing 0 to 9 Gla (gamma-carboxyglutamyl) residues performed in EDTA against anti- (normal) prothrombin showed that each of the Gla-deficient proteins contained as much antigenic activity as does the normal molecule. In the presence of Ca2+, however, normal prothrombin appeared to
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