Results 301 to 310 of about 174,020 (338)
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Congenital Prothrombin Deficiency
Seminars in Thrombosis and Hemostasis, 2009Prothrombin deficiency is among the rarest inherited coagulation disorders, with a prevalence of approximately 1:2,000,000. Two main phenotypes can be distinguished: (1) hypoprothrombinemia (type I deficiency), characterized by concomitantly low levels of activity and antigen; and (2) dysprothrombinemia (type II deficiency), characterized by the normal
Lancellotti, Stefano +1 more
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Pathophysiology of Haemostasis and Thrombosis, 1986
Using recombinant DNA techniques, DNA fragments coding for bovine prothrombin mRNA have been cloned and characterized. Structural studies have revealed that prothrombin mRNA encodes a precursor protein having an amino-terminal extension of 43 amino acid residues.
R T, MacGillivray, D M, Irwin
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Using recombinant DNA techniques, DNA fragments coding for bovine prothrombin mRNA have been cloned and characterized. Structural studies have revealed that prothrombin mRNA encodes a precursor protein having an amino-terminal extension of 43 amino acid residues.
R T, MacGillivray, D M, Irwin
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Hereditary Prothrombin Deficiency
New England Journal of Medicine, 1970Abstract Quantitative immunologic assay of the plasma of the proposita in a family with hereditary prothrombin deficiency demonstrated the defect to be due to an actual deficiency of the prothrombi...
H E, Kattlove, S S, Shapiro, M, Spivack
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American Journal of Physiology-Legacy Content, 1956
In the activation of a prothrombin solution, only part of the prothrombin becomes biothrombin, some becomes autoprothrombin I and some becomes autoprothrombin II. Thrombin-thrombin is also obtained, and perhaps other derivatives of prothrombin are formed. Prothrombin thus has multiple potentialities and these can be developed in diverse ways.
J A, PENNER, W H, SEEGERS
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In the activation of a prothrombin solution, only part of the prothrombin becomes biothrombin, some becomes autoprothrombin I and some becomes autoprothrombin II. Thrombin-thrombin is also obtained, and perhaps other derivatives of prothrombin are formed. Prothrombin thus has multiple potentialities and these can be developed in diverse ways.
J A, PENNER, W H, SEEGERS
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American Journal of Physiology-Legacy Content, 1958
In experiments with purified biothrombin, it was found that strong solutions of sodium citrate or protamine sulfate (0.1% w/v) or purified platelet factor 3 depress the esterase activity and leave the clotting power unaltered. Apparently a depression of esterase activity is beneficial for the autocatalytic activation of purified prothrombin.
R H, LANDABURU, W H, SEEGERS
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In experiments with purified biothrombin, it was found that strong solutions of sodium citrate or protamine sulfate (0.1% w/v) or purified platelet factor 3 depress the esterase activity and leave the clotting power unaltered. Apparently a depression of esterase activity is beneficial for the autocatalytic activation of purified prothrombin.
R H, LANDABURU, W H, SEEGERS
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Prothrombin madrid : A new familial abnormality of prothrombin
Thrombosis Research, 1979Abstract An abnormal prothrombin has been detected in a 13 yr-old girl, with history of excessive bleeding. Prothrombin time and activated partial thromboplastin time were markedly prolonged. Prothrombin activity was very low when measured by biological assay using either physiological activators (3% by one stage assay and 20 US u/ml by two stage ...
A, Bezeaud +4 more
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Prothrombin Time Standardization
Acta Clinica Belgica, 1987SummaryAs recommcndcd by the proper authorities, the prothrombin time results for patients under oral anticoagulant therapy arc reported by our laboratory in International Normalized Ratios (I.N.R.).For the calculation of the INR-values we use a calibration factor, the International Sensitivity Index (I.S.I.), provided by the manufacturer of the ...
L, Hameeuw, L, Sierens, A, Lust
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Prothrombin Segovia: A new congenital abnormality of prothrombin
Scandinavian Journal of Haematology, 1986A family with a new congenital dysprothrombinemia is presented. The propositus is a 21‐yr‐old man who presented simultaneously with hemartrosis of the left knee and an extensive hematoma following a minor trauma. Prothrombin time and activated partial thromboplastin time were prolonged.
E, Rocha +5 more
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Prothrombin Poissy: a new variant of human prothrombin
British Journal of Haematology, 1987SummaryA new congenital dysprothrombinaemia is described in a newborn baby girl who presented severe bleeding from the second day of life. Routine coagulation tests showed very prolonged prothrombin time and activated partial thromboplastin time with about 2% prothrombin activity in a one‐stage assay.
M D, Dumont +5 more
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Lupus, 2012
Research on antiphospholipid antibodies (aPL) and the thrombotic manifestations associated with these antibodies has grown since the description of anticardiolipin antibodies (aCL) by Harris and colleagues in the early 1980s. Antiprothrombin (aPT) antibodies are commonly detected by ELISA, using irradiated plates (aPT) or prothrombin in complex with ...
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Research on antiphospholipid antibodies (aPL) and the thrombotic manifestations associated with these antibodies has grown since the description of anticardiolipin antibodies (aCL) by Harris and colleagues in the early 1980s. Antiprothrombin (aPT) antibodies are commonly detected by ELISA, using irradiated plates (aPT) or prothrombin in complex with ...
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