Results 1 to 10 of about 7,260 (173)

Expression of the Human Serotonin 5-HT₇ Receptor Rescues Phenotype Profile and Restores Dysregulated Biomarkers in a Drosophila melanogaster Glioma Model

Cells, 2022
Gliomas are the most common primary brain tumors in adults. Significant progress has been made in recent years in identifying the molecular alterations involved in gliomas.
Florestan Courant, Marion Maravat, Wanyin Chen, David Gosset, Lauren Blot, Nadège Hervouet-Coste, Vincent Sarou-Kanian, Séverine Morisset-Lopez, Martine Decoville   +8 more
doaj   +1 more source

LINFOMA DE ZONA MARGINAL (MALT) EM GLÂNDULA LACRIMAL - UM RELATO DE CASO

Hematology, Transfusion and Cell Therapy, 2023
Objetivos: O propósito deste estudo é divulgar os conhecimentos sobre um caso raro de linfoma de zona marginal (MALT) em glândula lacrimal, visando ampliar o conhecimento sobre essa doença no meio científico.
PC Gontijo, MMM Zarife, MGT Carvalho, LCM Peixoto, L Alves, MC Piancastelli, MAS Ullmann   +6 more
doaj   +1 more source

ANÁLISE COMPREENSIVA DO GENE HCK EM NEOPLASIAS MIELOIDES: PERSPECTIVAS EM FUNÇÕES BIOLÓGICAS, PROGNÓSTICO E RESPOSTA À AGENTES ANTINEOPLÁSICOS

Hematology, Transfusion and Cell Therapy, 2023
Objetivos: As neoplasias mieloides são resultantes de alterações moleculares na célula-tronco hematopoiética, sendo a leucemia mieloide aguda (LMA) a mais agressiva e com piores desfechos clínicos.
MFL Carvalho, BO Almeida, MLP Bueno, HP Vicari, K Lima, EM Rego, FM Roversi, JA Machado-Neto   +7 more
doaj   +1 more source

Cell Type-specific Expression of the Mas Proto-oncogene in Testis [PDF]

Journal of Histochemistry & Cytochemistry, 2002
The Mas proto-oncogene encodes a G-protein-coupled receptor with the common seven transmembrane domains and may be involved in the actions of angiotensins. Because Mas is highly expressed in testis, we investigated the cell type-specificity and the onset of expression of the gene in this organ.
Natalia, Alenina, Tatjana, Baranova, Eugene, Smirnow, Michael, Bader, Andrea, Lippoldt, Eugene, Patkin, Thomas, Walther   +6 more
openaire   +2 more sources

TheMASProto-Oncogene Is Not Imprinted in Humans [PDF]

Genomics, 1996
Recently it was shown that the murine Mas gene, which is located less than 300 kb from the imprinted Igf2r gene, is also imprinted in Day 11.5 embryos with expression exclusively from the paternal allele. We have assigned the human MAS gene to chromosomal bands 6q25.3-q26 in close proximity to the IGF2R gene.
Riesewijk, A., Schepens, M., Mariman, E., Ropers, H., Kalscheuer, V.   +4 more
openaire   +4 more sources

Expression of the mouse and rat mas proto‐oncogene in the brain and peripheral tissues [PDF]

FEBS Letters, 1995
We isolated the mas proto‐oncogene from a mouse genomic library. Sequence analysis showed that it contains an open reading frame without intervening sequences. The amino acid sequence deduced confirms the seven‐transmembrane‐domain structure and exhibits 97% and 91% amino acid homology with the rat and the human Mas, respectively. In mice and rats, mas
Metzger, Rainer, Bader, Michael, Ludwig, Thomas, Berberich, Christof, Bunnemann, Bernd, Ganten, Detlev   +5 more
openaire   +2 more sources

Up-regulation of the Angiotensin II Type 1 Receptor by the MAS Proto-oncogene Is Due to Constitutive Activation of Gq/G11 by MAS [PDF]

Journal of Biological Chemistry, 2006
Coexpression of the MAS proto-oncogene with the angiotensin II type 1 (AT(1)) receptor in CHO-K1 cells has been reported to increase the number of [(3)H]angiotensin II-binding sites, although MAS does not bind [(3)H]angiotensin II. In HEK293 cells stably expressing AT(1) receptor-cyan fluorescent protein (CFP), MAS-yellow fluorescent protein (YFP ...
Meritxell, Canals, Laura, Jenkins, Elaine, Kellett, Graeme, Milligan   +3 more
openaire   +2 more sources

TheMASProto-oncogene Is Imprinted in Human Breast Tissue

Genomics, 1997
The human MAS proto-oncogene is situated at 6q25.3-q26, a region that is homologous to mouse chromosome 17 where two parentally imprinted genes (Mas and Igf2r) have previously been identified. We investigated the imprinting status of MAS in adult lesions to establish the imprinting status of this gene in humans, as certain imprinted genes are known to ...
Miller, Nicola, McCann, Amanda H., Connell, David, Pedersen, Inge S., Spiers, Valerie, Gorey, Thomas, Dervan, Peter A.   +6 more
openaire   +2 more sources

Localization of the Mas proto-oncogene to a densely marked region of mouse chromosome 17 associated with genomic imprinting

Genomics, 1992
The mouse homolog of the human proto-oncogene MAS was mapped by two interspecific backcrosses to the proximal portion of MMU17. Higher resolution mapping was accomplished through the analysis of genotypes duplicated or deleted for a megabase-size subregion within MMU17.
J A, Cebra-Thomas, J Y, Tsai, S H, Pilder, N G, Copeland, N A, Jenkins, L M, Silver   +5 more
openaire   +2 more sources

Gut microbes–spinal connection is required for itch sensation

Gut Microbes
The gut microbiota has been linked to a number of neurological disorders. However, it is unclear whether the gut microbiota is involved in the genesis of chronic itch, a refractory condition that afflicts patients both physically and mentally.
Tong Jin, Si-Yuan Li, Hong-Li Zheng, Xiao-Dan Liu, Yue Huang, Gan Ma, Ya-Xuan Zhao, Xiao-Tian Zhao, Li Yang, Qi-Hui Wang, Hong-Jun Wang, Chengyong Gu, Zhiqiang Pan, Fuqing Lin   +13 more
doaj   +1 more source