Results 161 to 170 of about 35,987 (237)

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

GDF15 and its receptors as pathways mediating smoking related weight change. [PDF]

EBioMedicine
Tinworth AC, Iona A, Yao P, Millwood IY, Fry H, Clarke J, Wang B, Mazidi M, Kartsonaki C, Walters RG, Du H, Yu C, Chen Y, Sun D, Yang L, Schmidt DV, Lv J, Avery D, Li L, Bennett DA, Peto R, Clarke R, Bragg F, Chen Z, China Kadoorie Biobank Collaborative Group.   +24 more
europepmc   +1 more source

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

Advanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao, Xianping Liu, Xu Chu, Feixiang Chen, Ruicheng Shi, Zonghao Liu, Yelin Wu, Yanyan Liu, Wenbo Bu   +8 more
wiley   +1 more source

Weifuchun ( ) exerts therapeutic effects on gastric fundic gland polyps by promoting ferroptosis. [PDF]

J Tradit Chin Med
Yue LI, Jinyan D, Shanshan PI, Yingjuan Z, Dan Z, Yi G, Yong'an YE, Xiaobin Z, Hongbo DU.   +8 more
europepmc   +1 more source

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy

Advanced Science, EarlyView.
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie, Tianyi Ji, Zixin Wan, Jie Huang, Han Li, Lingjiao Zou, Zhen Yang, Jiarui Li, Yuqi Guan, Lei Ruan, Jinhua Yan, Cuntai Zhang   +11 more
wiley   +1 more source

DNA variants detected in primary and metastatic lung adenocarcinoma: a case report and review of the literature. [PDF]

Lab Med
Kelly C, Raymond C, Han S, Lin Y, Chen L, Huang G, Dong J.   +6 more
europepmc   +1 more source

Abnormal β‐Hydroxybutyrylation Modification of ARG1 Drives Reprogramming of Arginine Metabolism to Promote the Progression of Colorectal Cancer

Advanced Science, EarlyView.
Alterations in arginine metabolism and β‐hydroxybutyrylation (Kbhb) modifications play a critical role in tumor progression. This study reveals valuable insights into arginine metabolism reprogramming involving the ARG1‐Kbhb/P300/SLC3A2 signaling axis and uncovers an effective therapy combining BHB with ARG1 inhibitor through conventional enzymatic and
Chuman Lin, Zhiyang Li, Xiaotong Zhu, Wanbing Zhou, Xiansheng Lu, Jiali Zheng, Jie Lin   +6 more
wiley   +1 more source

Angiotensin (1-7) and Alamandine: Similarities and differences [PDF]

, 2016
Apostolopoulos, Vasso, Qaradakhi, Tawar, Zulli, Anthony   +2 more
core   +1 more source

Network Pharmacology and Molecular Docking-Based Approach to Explore Potential Bioactive Compounds from <i>Kaempferia parviflora</i> on Chemokine Signaling Pathways in the Treatment of Psoriasis Disease. [PDF]

Int J Mol Sci
Sakuludomkan C, Khowsathit J, Thippraphan P, Koonrungsesomboon N, Takuathung MN, Taychaworaditsakul W.   +5 more
europepmc   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source