Results 211 to 220 of about 440,834 (358)

Hsa_circ_0000437 promotes the progression of rheumatic valvular heart disease by activating the mitogen-activated protein kinase signaling pathways after sponging let-7f-5p and targeting RAS-like proto-oncogene B. [PDF]

Hum Cell
Zhu L, Li N, Shi H, Song J, Fang Z, Shen Q, Zhu X, Dan Y, Shao G, Sun L.   +9 more
europepmc   +1 more source

Oncogenic activation of the human trk proto-oncogene by recombination with the ribosomal large subunit protein L7a.

, 1990
Andrew Ziemiecki, Rainer Müller, Xuebin Fu, Nancy E. Hynes, Sara C. Kozma   +4 more
openalex   +2 more sources

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Structure of the protein encoded by the chicken proto-oncogene c-myb

Molecular and Cellular Biology, 1986
S. Gerondakis, J. Bishop
semanticscholar   +1 more source

The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene

, 2008
Ling Lin, Jianhua Zhang, Leelamma M. Panicker, William F. Simonds   +3 more
openalex   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos

Molecular and Cellular Biology, 1989
P. Chavrier, U. Janssen‐Timmen, M. Mattei, M. Zerial, R. Bravo, P. Charnay   +5 more
semanticscholar   +1 more source

Synergistic target network construction and dynamic simulation analysis based on a prospective systems pharmacology strategy. [PDF]

Medicine (Baltimore)
Li H, Zheng Z, Zhen G, Tang K, Fang H, Wang J, Liu X, Zhu D.   +7 more
europepmc   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway

Molecular and Cellular Biology, 1987
J. Papkoff, ANTHONY M.C. Brown, H. Varmus   +2 more
semanticscholar   +1 more source