Results 21 to 30 of about 348,341 (313)

An extremely rare case of concurrent BRAF V600E mutation driven hairy cell leukemia and melanoma: case report and review of literature

Autopsy and Case Reports, 2017
BRAF protein is a serine/threonine kinase with 766 amino acids. Approximately 15% of human cancers harbor BRAF mutations as well as other BRAF anomalies (amplifications, fusions).
Amir Ghorbani-Aghbolaghia, Mirna Lechpammer, Saba F. Ali, Nam K. Ku, Denis M. Dwyre, Hooman H. Rashidi   +5 more
doaj   +1 more source

Tuning of Alternative Splicing - Switch From Proto-Oncogene to Tumor Suppressor [PDF]

International Journal of Biological Sciences, 2013
STAT5B, a specific member of the STAT family, is intimately associated with prostate tumor progression. While the full form of STAT5B is thought to promote tumor progression, a naturally occurring truncated isoform acts as a tumor suppressor.
Aleksandra Shchelkunova, Boris Ermolinsky, Meghan Boyle, Ivan Mendez, Michael Lehker, Karen S. Martirosyan, Alexander V. Kazansky
doaj   +1 more source

Effects of Antibiotics and a Proto-Oncogene Homolog on Destruction of Protein Translocator SecY [PDF]

Science, 2009
Jamming Protein Translocation Antibiotics are tremendously important drugs in modern medicine, yet we are still learning precisely how they work. SecY is a bacterial membrane protein that is part of a complex that allows protein secretion across the membrane. Van Stelten
van Stelten, Johna, Silva, Filo, Belin, Dominique, Silhavy, T. J.   +3 more
openaire   +4 more sources

While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable [PDF]

, 2003
In mammals, the three classical ras genes encode four highly homologous proteins, N-Ras, H-Ras, and the isoforms K-Ras 4A and 4B. Previous studies have shown that K-ras is essential for mouse development and that while K-ras 4A and 4B are expressed ...
Patek, C. E., Ann-Marie Ritchie, Melton, D. W., Doig, Jennifer, Arends, Mark J, D James Williamson, Charles E Patek, Arends, M. J., Ritchie, A. M., Plowman, Sarah J, Williamson, D James, Maureen J O'sullivan, Ritchie, Ann-Marie, Melton, David W, Sarah J Plowman, Hooper, Martin L, David W Melton, Harrison, David J, Arends, Mark J; id_orcid, O'Sullivan, M. J., Harrison, D. J., Hooper, M. L., Plowman, S. J., David J Harrison, O'Sullivan, Maureen J, Jennifer Doig, Doig, J., Martin L Hooper, Patek, Charles E, Mark J Arends, Williamson, D. J.   +30 more
core   +1 more source

Histological and immunohistochemical findings in recurrent nevi [PDF]

Anais Brasileiros de Dermatologia
Background Recurrent nevi (RN) arise from the incomplete removal of a benign melanocytic lesion. They may present with clinical and dermoscopic characteristics similar to melanomas and are a potential mimic of neoplasia.
Maisa Aparecida Matico Utsumi Okada, Renata Heck, Renato Marchiori Bakos   +2 more
doaj   +1 more source

Frequency of Expression of BRAF V600E and Epidermal Growth Factor Receptor (EGFR) in Ameloblastoma

Asian Pacific Journal of Cancer Biology, 2022
Objective: To determine the Immunohistochemical expression of BRAF V600E and Epidermal growth factor receptor (EGFR) in ameloblastoma and correlate the expression with age and gender of patients, and patterns and types of ameloblastoma.
Namrah Bashir, Muhammad Asif, Iqraa Shakeel Malik, Nighat Araa, Farhat Rashid, Hafeez Uddin, Aieman Bashir, Numrah Shakeel Malik   +7 more
doaj   +1 more source

Selective induction of cell death in melanoma cell lines through targeting of Mcl-1 and A1. [PDF]

, 2012
Melanoma is an often fatal form of skin cancer which is remarkably resistant against radio- and chemotherapy. Even new strategies that target RAS/RAF signaling and display unprecedented efficacy are characterized by resistance mechanisms.
Berking, Carola, Senft Daniela, Robert Besch, Carola Berking, Saskia A Graf, Claudia Kammerbauer, Thomas Ruzicka, Graf, Saskia A., Besch, Robert, Graf Saskia A., Senft, Daniela, Berking Carola, Kammerbauer, Claudia, Daniela Senft, Besch Robert, Kammerbauer Claudia, Ruzicka, Thomas, Saskia A. Graf, Ruzicka Thomas   +18 more
core   +1 more source

Ganglioglioma and gangliocytoma: a review for pathologists [PDF]

Journal of Pathology and Translational Medicine
Ganglioglioma and gangliocytoma are rare, predominantly low-grade neuroepithelial tumors that commonly present with epilepsy in children and young adults. Advances in molecular profiling have improved understanding of their pathogenesis, highlighting key
Gianfranco E. Umeres-Francia, Melissa Mejia-Bautista, Pouya Jamshidi, Jared T. Ahrendsen   +3 more
doaj   +1 more source

Clinical Significance of the Transcription Factor SOX11, Cell-Cell Adhesion Protein E-cadherin and Zinc Finger Protein BCL11A in the Diagnosis of Breast Cancer

Archives of Pharmaceutical Sciences Ain Shams University, 2021
Transcription factors (TFs) as SRY-Box transcription factor 11 (SOX11) and B-cell lymphoma/leukemia 11A (BCL11A) role in breast cancer (BC) as well as their effect on epithelial cadherin (E-cadherin) membrane protein which is a metastasis suppressor is a
Salma Salama, Nadia Hamdy, Reham El-Shimy, Hala El-Mesallamy   +3 more
doaj   +1 more source

Effects of Proto-oncogene Protein DEK on PCAF Localization [PDF]

Biomolecules and Therapeutics, 2007
The proto-oncogene protein DEK is a nuclear binding phosphoprotein that has been associated with various human diseases including leukemia. Histone acetylation is an important post-translational modification which plays important role in transcriptional regulation.
In-Seon Lee, Seok-Cheol Lee, Jae-Hwi Lee, Sang-Beom Seo   +3 more
openaire   +1 more source