Results 21 to 30 of about 346,938 (313)

Effects of Antibiotics and a Proto-Oncogene Homolog on Destruction of Protein Translocator SecY [PDF]

Science, 2009
Jamming Protein Translocation Antibiotics are tremendously important drugs in modern medicine, yet we are still learning precisely how they work. SecY is a bacterial membrane protein that is part of a complex that allows protein secretion across the membrane. Van Stelten
van Stelten, Johna, Silva, Filo, Belin, Dominique, Silhavy, T. J.   +3 more
openaire   +4 more sources

While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable [PDF]

, 2003
In mammals, the three classical ras genes encode four highly homologous proteins, N-Ras, H-Ras, and the isoforms K-Ras 4A and 4B. Previous studies have shown that K-ras is essential for mouse development and that while K-ras 4A and 4B are expressed ...
Patek, C. E., Ann-Marie Ritchie, Melton, D. W., Doig, Jennifer, Arends, Mark J, D James Williamson, Charles E Patek, Arends, M. J., Ritchie, A. M., Plowman, Sarah J, Williamson, D James, Maureen J O'sullivan, Ritchie, Ann-Marie, Melton, David W, Sarah J Plowman, Hooper, Martin L, David W Melton, Harrison, David J, Arends, Mark J; id_orcid, O'Sullivan, M. J., Harrison, D. J., Hooper, M. L., Plowman, S. J., David J Harrison, O'Sullivan, Maureen J, Jennifer Doig, Doig, J., Martin L Hooper, Patek, Charles E, Mark J Arends, Williamson, D. J.   +30 more
core   +1 more source

Frequency of Expression of BRAF V600E and Epidermal Growth Factor Receptor (EGFR) in Ameloblastoma

Asian Pacific Journal of Cancer Biology, 2022
Objective: To determine the Immunohistochemical expression of BRAF V600E and Epidermal growth factor receptor (EGFR) in ameloblastoma and correlate the expression with age and gender of patients, and patterns and types of ameloblastoma.
Namrah Bashir, Muhammad Asif, Iqraa Shakeel Malik, Nighat Araa, Farhat Rashid, Hafeez Uddin, Aieman Bashir, Numrah Shakeel Malik   +7 more
doaj   +1 more source

Histological and immunohistochemical findings in recurrent nevi [PDF]

Anais Brasileiros de Dermatologia
Background Recurrent nevi (RN) arise from the incomplete removal of a benign melanocytic lesion. They may present with clinical and dermoscopic characteristics similar to melanomas and are a potential mimic of neoplasia.
Maisa Aparecida Matico Utsumi Okada, Renata Heck, Renato Marchiori Bakos   +2 more
doaj   +1 more source

Clinical Significance of the Transcription Factor SOX11, Cell-Cell Adhesion Protein E-cadherin and Zinc Finger Protein BCL11A in the Diagnosis of Breast Cancer

Archives of Pharmaceutical Sciences Ain Shams University, 2021
Transcription factors (TFs) as SRY-Box transcription factor 11 (SOX11) and B-cell lymphoma/leukemia 11A (BCL11A) role in breast cancer (BC) as well as their effect on epithelial cadherin (E-cadherin) membrane protein which is a metastasis suppressor is a
Salma Salama, Nadia Hamdy, Reham El-Shimy, Hala El-Mesallamy   +3 more
doaj   +1 more source

Selective induction of cell death in melanoma cell lines through targeting of Mcl-1 and A1. [PDF]

, 2012
Melanoma is an often fatal form of skin cancer which is remarkably resistant against radio- and chemotherapy. Even new strategies that target RAS/RAF signaling and display unprecedented efficacy are characterized by resistance mechanisms.
Berking, Carola, Senft Daniela, Robert Besch, Carola Berking, Saskia A Graf, Claudia Kammerbauer, Thomas Ruzicka, Graf, Saskia A., Besch, Robert, Graf Saskia A., Senft, Daniela, Berking Carola, Kammerbauer, Claudia, Daniela Senft, Besch Robert, Kammerbauer Claudia, Ruzicka, Thomas, Saskia A. Graf, Ruzicka Thomas   +18 more
core   +1 more source

Effects of Proto-oncogene Protein DEK on PCAF Localization [PDF]

Biomolecules and Therapeutics, 2007
The proto-oncogene protein DEK is a nuclear binding phosphoprotein that has been associated with various human diseases including leukemia. Histone acetylation is an important post-translational modification which plays important role in transcriptional regulation.
In-Seon Lee, Seok-Cheol Lee, Jae-Hwi Lee, Sang-Beom Seo   +3 more
openaire   +1 more source

BCR-ABL1 tyrosine kinase sustained MECOM expression in chronic myeloid leukaemia [PDF]

, 2012
MECOM oncogene expression correlates with chronic myeloid leukaemia (CML) progression. Here we show that the knockdown of MECOM (E) and MECOM (ME) isoforms reduces cell division at low cell density, inhibits colony-forming cells by 34% and moderately ...
Jørgensen, Heather G., Holyoake, T.L., Holyoake, T., Abed El Baky, Mohamed, Bartholomew, C., Melo, Junia V., Roy, P., Melo, J.V., Abed El Baky, M., Roy, S., Jørgensen, H., Jorgensen, H.G., Strathdee, G., Strathdee, Gordon, Melo, J., Roy, Swagata, Holyoake, Tessa L., Roy, Poornima, Bartholomew, Christopher   +18 more
core   +1 more source

Cell proliferation and apoptosis in gastric cancer and intestinal metaplasia Proliferação celular e apoptose em câncer gástrico e metaplasia intestinal

Arquivos de Gastroenterologia, 2005
BACKGROUND: Higher proliferation is commonly observed in cancer cells. Apoptosis can be a useful measure of a tumor cell kinetic. Alteration of the balance between proliferation and apoptosis is associated with cancer.
Nora Manoukian Forones, Ana Paula Souza Carvalho, Oswaldo Giannotti-Filho, Laércio Gomes Lourenço, Celina Tizuko Fujiyama Oshima   +4 more
doaj   +1 more source

The protein encoded by the human proto-oncogene c-myc. [PDF]

Proceedings of the National Academy of Sciences, 1984
The proto-oncogene c-myc may play a role in controlling the growth and division of normal cells, and abnormalities of the gene have been implicated in the genesis of a substantial variety of human tumors. To facilitate further study of these issues, we developed antisera that permit the identification and isolation of the protein encoded by the human ...
G, Ramsay, G I, Evan, J M, Bishop
openaire   +2 more sources