BRAF inhibitor or BRAF/MEK inhibitor treatment for patients with metastatic BRAF V600E mutated differentiated thyroid cancer [PDF]
Archives of Endocrinology and MetabolismObjective: The aim of this study is to demonstrate the real-life efficacy of BRAF and MEK inhibitors in patients with advanced thyroid cancer. Subjects and methods: This retrospective study evaluated the clinical efficacy of either a BRAF inhibitor ...
Inbar Finkel +9 more
doaj +2 more sources
BRAFV600E Mutation Enhances Estrogen-Induced Metastatic Potential of Thyroid Cancer by Regulating the Expression of Estrogen Receptors [PDF]
Endocrinology and Metabolism, 2022 Background Cross-talk between mitogen-activated protein kinase and estrogen has been reported; however, the role of BRAFV600E in the estrogen responsiveness of thyroid cancer is unknown.
Minjun Kim +8 more
doaj +1 more source
Mouse Models as a Tool for Understanding Progression in Braf-Driven Thyroid Cancers [PDF]
Endocrinology and Metabolism, 2019 The development of next generation sequencing (NGS) has led to marked advancement of our understanding of genetic events mediating the initiation and progression of thyroid cancers. The NGS studies have confirmed the previously reported high frequency of
Iñigo Landa, Jeffrey A. Knauf
doaj +1 more source
B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse. [PDF]
PLoS ONE, 2010 The B-raf proto-oncogene exerts essential functions during development and adulthood. It is required for various processes, such as placental development, postnatal nervous system myelination and adult learning and memory.
Agathe Valluet +6 more
doaj +1 more source
Molecular Correlates and Nuclear Features of Encapsulated Follicular-Patterned Thyroid Neoplasms [PDF]
Endocrinology and Metabolism, 2021 Background Assessing nuclear features is diagnostically challenging in the aspect of thyroid pathology. The aim of this study was to determine whether pathologists could distinguish BRAF-like and RAS-like nuclear features morphologically and identify ...
Chan Kwon Jung +10 more
doaj +1 more source
Oman Medical Journal, 2021 Objectives: We sought to determine the immunohistochemistry expression of mismatch repair (MMR) and BRAF V600E proteins in sporadic young-onset colorectal cancer (CRC) and their association with clinicopathological features in the Kelantan population ...
Zubaidah Saizul +5 more
doaj +1 more source
Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. [PDF]
, 2015 BackgroundKey effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).MethodsWe used NSCLC ...
Aljilani, Amir +7 more
core +2 more sources
Mutation Profile of Well-Differentiated Thyroid Cancer in Asians [PDF]
Endocrinology and Metabolism, 2015 Recent advances in molecular diagnostics have led to significant insights into the genetic basis of thyroid tumorigenesis. Among the mutations commonly seen in thyroid cancers, the vast majority are associated with the mitogen-activated protein kinase ...
Young Shin Song +2 more
doaj +1 more source
An Activating Mutation in sos-1 Identifies Its Dbl Domain as a Critical Inhibitor of the Epidermal Growth Factor Receptor Pathway during Caenorhabditis elegans Vulval Development [PDF]
, 2007 Proper regulation of receptor tyrosine kinase (RTK)-Ras-mitogen-activated protein kinase (MAPK) signaling pathways is critical for normal development and the prevention of cancer.
Elgort, Marc G. +7 more
core +2 more sources
Brazilian Journal of Oncology, 2022 Objectives: Immune-checkpoint inhibitors (ICI) and targeted-therapies (TT) have become standard options for BRAF-V600 metastatic melanomas (MM). Recently, randomized trials (RCT) addressed the efficacy of combined approaches, with conflicting results. We
Mauricio Fernando Silva Almeida Ribeiro +11 more
doaj +1 more source