Results 101 to 110 of about 48,310 (191)

FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes

FEBS Open Bio, Volume 15, Issue 8, Page 1319-1335, August 2025.
FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang, Wenhui Yu, Cui Dang, Jingjing Zhang, Jiahan Lu, Jing Xue   +5 more
wiley   +1 more source

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

The Role of PIWI‐Interacting RNA in Urologic Carcinoma and Its Clinical Implications

Cancer Reports, Volume 8, Issue 8, August 2025.
ABSTRACT Piwi‐interacting RNA (piRNA) represents a class of small non‐coding RNA molecules, typically ranging in length from 18 to 35 nucleotides. These molecules are critically involved in the preservation of genomic integrity and the regulation of protein translation processes.
Jiajia Cai, Shirui Jiang, Dongdong Lu, Ghulam Murtaza, Mingbang Wang, Yuqing Li, Da Shi, Yingrui Li, Hu Fang, Song Wu   +9 more
wiley   +1 more source

Protective mechanism of polysaccharides from Phellinus linteus on H9c2 cardiomyocyte injury induced by hypoxia/reoxygenation. [PDF]

BMC Res Notes
Ren X, Mei Q, Zhou Y, Jiang L, Liu F, Wang J.   +5 more
europepmc   +1 more source

Quinazolinedione Derivatives as Potential Anticancer Agents Through Apoptosis Induction in MCF-7. [PDF]

Int J Mol Sci
Limboonreung T, Suansilpong T, Jumjitvi P, Lohawittayanan D, Krobthong S, Charoensutthivarakul S.   +5 more
europepmc   +1 more source

Screening of Theaflavins That Inhibit Proliferation of Nasopharyngeal Carcinoma Cells Through Metabolomics Approaches

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
This study investigated the effects of theaflavin‐3,3′‐digallate (TF3) markedly suppresses the proliferation, migration, invasion of nasopharyngeal carcinoma cells while promoting apoptosis in a dose‐dependent manner. Metabolomic profiling identified 584 altered metabolites, revealing key disruptions in ABC transporter activity and amino acid ...
Chunpeng Wan, Xiaomeng Hu, Puxiang Yang, Mingxi Li, Muhammad Farrukh Nisar, Zihao Zhou, Yudi Gan, Yi Cai, Zhonghua Liu   +8 more
wiley   +1 more source

PLIP 2025: introducing protein-protein interactions to the protein-ligand interaction profiler. [PDF]

Nucleic Acids Res
Schake P, Bolz SN, Linnemann K, Schroeder M.   +3 more
europepmc   +1 more source

Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Eugenol (Eug), a volatile phenolic bioactive compound with formula of C10H12O2 have been reported with anticancer, antidiabetic, cardio‐ and pulmonary protective role. Moreover, it has the ability to improve gut health and prevent neurodegenerative disorders. According to WHO, the safe dose of Eug is 2.5 mg/kg for consumption.
Ahmad Mujtaba Noman, Muhammad Tauseef Sultan, Aimen Mazhar, Waqas Ahmad Khan, Muhammad Imran, Muzzamal Hussain, Ehab M. Mostafa, Ahmed H. El‐Ghorab, Mohammed M. Ghoneim, Samy Selim, Mohamed A. Abdelgawad, Entessar Al Jbawi, Suliman A. Alsagaby, Waleed Al Abdulmonem   +13 more
wiley   +1 more source

<i>Circaea mollis</i> Siebold & Zucc. Induces Apoptosis in Colorectal Cancer Cells by Inhibiting c-Myc Through the Mediation of RPL5. [PDF]

Int J Mol Sci
Park SM, Kim N, Park YR, Kim SW, Jung JH, Na YC, Kwon D, Kim H, Jang HJ.   +8 more
europepmc   +1 more source

Anticancer Molecular Mechanisms of Epigallocatechin Gallate: An Updated Review on Clinical Trials

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Epigallocatechin gallate (EGCG), a bioactive compound abundantly exists in green tea and grapes with strong antioxidant activity and anticancer potential is a suitable approach to reduce the cancer burden. The invitro and invivo anticancer studies of EGCG proved anticancer and anti‐tumor effect through modulation of cancer signaling pathways, reduction
Ahmad Mujtaba Noman, Muhammad Tauseef Sultan, Aimen Mazhar, Iqra Baig, Jawaria Javaid, Muzzamal Hussain, Muhammad Imran, Suliman A. Alsagaby, Waleed Al Abdulmonem, Ahmed Mujtaba, Tadesse Fenta Yehuala, Mohammed M. Ghoneim, Ehab M. Mostafa, Mohamed A. Abdelgawad   +13 more
wiley   +1 more source